New radiation treatment shows promise for skin cancer in immunocompromised patients

NCT ID NCT06615635

First seen Sep 30, 2025 · Last updated Jun 23, 2026 · Updated 25 times

Summary

This study tests a new type of radiation therapy called DaRT for people with a common skin cancer (squamous cell carcinoma) who have weakened immune systems. The treatment involves placing tiny radioactive seeds directly into the tumor to kill cancer cells from the inside. Researchers will track how well the tumors shrink and how long patients live, with up to 28 participants.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Alliance Dermatology

    RECRUITING

    Phoenix, Arizona, 85032, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Banner Health

    RECRUITING

    Gilbert, Arizona, 35234, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Bassett Healthcare

    RECRUITING

    Cooperstown, New York, 13326, United States

    Contact Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Day Star Skin Cancer Center

    NOT_YET_RECRUITING

    Poinciana, Florida, 33445, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Email: •••••@•••••

  • Emory University

    RECRUITING

    Atlanta, Georgia, 30308, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hadassah Medical Center

    NOT_YET_RECRUITING

    Jerusalem, 9112001, Israel

    Contact Email: •••••@•••••

  • Hollywood Dermatology

    RECRUITING

    Hollywood, Florida, 33201, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Email: •••••@•••••

  • Integrity Research Clinical Associates

    NOT_YET_RECRUITING

    Boca Raton, Florida, 33445, United States

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

  • Mayo Clinic

    NOT_YET_RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Palm Beach Dermatology Group

    NOT_YET_RECRUITING

    Palm Beach, Florida, 33848, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Us Dermatology Parthners

    RECRUITING

    Phoenix, Arizona, 85006, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

DaRT seeds (radioactive sources that release alpha radiation directly into the tumor)

What this could lead to

If it works, this could offer a new treatment option for skin cancer in people with weakened immune systems, who often have limited choices.

What could go wrong

This is a small, early-stage study with only 28 participants, so results may not apply to everyone. The treatment involves radiation, which can cause side effects like skin irritation or damage to nearby tissue.

Conditions

The condition(s) this trial relates to.

immunodeficiency disease skin cancer skin neoplasm skin squamous cell carcinoma squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.