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Night shift workers' skin may struggle to fix sun damage, study suggests

NCT ID NCT04122456

Recruiting now Knowledge-focused Sponsor: Wright State University Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This pilot study investigates whether working night shifts changes how the skin repairs DNA damage caused by ultraviolet B (UVB) radiation, a type of artificial sunlight. Researchers will take small skin samples from 48 fair-skinned day and night shift workers at two times of day (8 am and 4 pm) and expose them to UVB in the lab. They will measure DNA repair activity and clock gene expression to see if shift work affects the skin's ability to respond to sun damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Ultraviolet B radiation exposure to skin biopsies in the lab
What this could lead to
If successful, this study could help explain why night shift workers have a higher risk of skin cancer and point toward preventive strategies.
What could go wrong
This is a small pilot study with only 48 participants, so results may not apply to everyone. It measures lab-based responses, not actual cancer outcomes.

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Conditions

The condition(s) this trial relates to.

skin cancer skin neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SKIN CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Wright State Physicians

    RECRUITING

    Fairborn, Ohio, 45324, United States

    Contact Phone: •••-•••-••••

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