SKIN CANCER

This study tests the drug atezolizumab in about 200 adults with different incurable solid tumors. Researchers use each person's tumor DNA and RNA to see if their cancer might respond to the drug. Participants receive the same dose every 3 weeks, and the study checks if the geneti…

This study tests a new drug, KESONOTIDE™, in people with advanced solid tumors like prostate, breast, lung, ovarian, pancreatic, skin cancer, or glioblastoma. The main goal is to check if the drug is safe and tolerable, and to find the right dose. About 80 adults will take part i…

This study tests a treatment made from a patient's own immune cells (tumor-infiltrating lymphocytes, or TILs) combined with chemotherapy and interleukin-2 for people with advanced skin cancers (cutaneous squamous cell carcinoma or Merkel cell carcinoma) that have not responded to…

This study tests an experimental oral drug called Alintegimod combined with standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if the com…

This early-stage trial tests a new drug, ONM-501, injected directly into tumors, either alone or with another drug (cemiplimab), for people with advanced solid tumors or lymphomas that have not responded to other treatments. The study aims to find the safest dose and check for si…

This study tests a new approach for people with head and neck cancer that has come back or spread and cannot be removed by surgery. Tiny devices that give off a special type of radiation are placed directly into the tumor, and patients also receive an immunotherapy drug called pe…

This study looks at whether high-intensity exercise and a high-fiber diet are possible and helpful for people with advanced melanoma who are receiving immunotherapy. The goal is to see if these lifestyle changes can improve gut health and immune function. The study will involve 4…

This study tests whether using special lasers followed by a prescription ointment can effectively treat common skin cancers like basal and squamous cell carcinoma. About 100 adults with biopsy-confirmed skin cancers will receive the laser treatment and then apply the ointment at …

This study tests a new treatment called DaRT, where tiny devices that give off a special type of radiation are placed directly into tumors. It is for people with skin cancer, mouth cancer, or soft tissue cancer that has not spread too far. The goal is to see if the tumors shrink …

This study tests if freezing part of a growing tumor (cryoablation) combined with two immunotherapy drugs (ipilimumab and nivolumab) can help control advanced melanoma that stopped responding to prior treatment. About 37 adults with unresectable melanoma will receive the combinat…

This study tests whether a telemedicine tool can help primary care doctors find skin tumors earlier. About 1,440 people with suspicious moles or light skin types will have their skin checked remotely. The goal is to see if this approach can catch skin cancer sooner and reduce the…

This study tests whether an AI system (Dermalyser) can help primary care doctors better tell skin cancer from harmless moles. About 3000 adults in five countries will take part. Doctors in some clinics will use the AI as a decision aid, while others will follow standard care. The…

This early-phase trial tests whether taking vitamin A and nicotinamide (a form of vitamin B3) can help prevent skin cancer in kidney transplant recipients who have already had skin cancer. The study will enroll 30 adults and measure changes in blood vitamin levels to see if the s…

This study looks at whether giving people personalized information about their skin cancer risk can encourage them to protect their skin. About 2,900 adults from community health centers will provide a saliva sample for genetic testing and answer questions about their sun habits.…

This study tests a program called MyCarePulse and ASCENT that helps cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either get the program or standard care. Researchers will check if the program improves food securit…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study looks at whether a single dose of meloxicam (a pain reliever) can control pain better than the usual ibuprofen after Mohs surgery for skin cancer. About 300 adults will be split into three groups: one gets a low dose of meloxicam, one gets a higher dose, and one gets s…

This study looks at blood samples from 20 adults with melanoma or other skin cancers to see if certain markers in the blood can predict how well treatment works or how long people live. Participants give blood during their regular care. The goal is to find better ways to monitor …

This study is for people with a common type of skin cancer called cutaneous squamous cell carcinoma. Before their scheduled surgery to remove the tumor, they will receive a flu shot injected directly into the cancer. The goal is to see if this can activate immune cells to better …

This study collects live tumor tissue from 2,000 people with various cancers to understand why some respond to immunotherapy and others don't. Participants give a biopsy as part of their normal care, and researchers analyze the samples in the lab. The goal is to develop better wa…

This study looks at why some people get sick from heat and sun exposure while others don't. Researchers will test 80 healthy adults from Denmark and Greece in controlled heat and UV conditions. The goal is to create personalized alerts and advice to help people stay safe during h…

This study tests if a handheld laser probe (Raman spectroscopy) can accurately measure how far skin cancer tumors spread. Twenty adults with basal or squamous cell carcinoma will have their tumors scanned with the probe. The goal is to see if this light-based method can help doct…

This study looks at how electrochemotherapy—a treatment that uses electric pulses to help chemotherapy drugs enter tumor cells—changes the environment around melanoma skin tumors. Researchers will collect tissue samples from 150 adults with melanoma before and after treatment to …

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning sooner than standard scans. Researchers will follow 100 people with various solid tumors to see if early detection leads to better treatment options. The goal is to improve how w…

This study is looking at how effective immunotherapy is as a first treatment for metastatic melanoma that has spread. Researchers will check if a marker called PD-L1, found in tumors and blood, can help predict who will respond well. About 100 adults with advanced melanoma will t…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…