SKIN CANCER

This study looks at whether high-intensity exercise and a high-fiber diet are practical and helpful for people with advanced melanoma who are receiving immunotherapy. About 40 adults will be assigned to exercise, diet changes, both, or standard care. The goal is to see if these l…

This study tests a new device that delivers a special type of radiation directly into skin tumors. The goal is to see if it can shrink or control the cancer. The study is for adults with certain types of skin cancer, including squamous cell carcinoma and basal cell carcinoma. Par…

This study tests a new type of radiation therapy called DaRT for people with a common skin cancer (squamous cell carcinoma) who have weakened immune systems. The treatment involves placing tiny radioactive seeds directly into the tumor to kill cancer cells from the inside. Resear…

This study tests a device called DaRT that delivers a unique type of radiation (alpha particles) directly into tumors. It is designed for people with certain skin cancers, mouth cancers, or soft tissue sarcomas that are accessible for direct injection. The goal is to see if this …

This study tests whether a vacuum dressing (negative pressure wound therapy) reduces infection compared to standard bandages after skin graft surgery for leg tumors. About 242 adults will be randomly assigned to one of the two dressings. The main goal is to see if the vacuum dres…

This study tests whether freezing part of a growing tumor (cryoablation) can help two immunotherapy drugs, ipilimumab and nivolumab, work better in people with advanced melanoma that has stopped responding to initial treatment. About 37 adults whose melanoma is growing despite pr…

This study tests an experimental oral drug called Alintegimod (7HP349) combined with two standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, and liver cancers. The trial has two parts: first, finding a safe dose (p…

This trial is testing a new approach for people with head and neck cancer that has come back or spread and cannot be removed. It combines a device called DaRT, which is a tiny radioactive seed placed directly into the tumor, with the immunotherapy drug pembrolizumab (Keytruda). T…

This study tests a new drug, KESONOTIDE™, in people with advanced solid tumors like prostate, breast, lung, ovarian, brain, pancreas, or skin cancer. The trial has two phases: first, finding the safest dose, then testing that dose in a larger group. About 80 participants will be …

This study tests a treatment using a patient's own immune cells (called tumor-infiltrating lymphocytes or TILs) combined with chemotherapy and interleukin-2 for people with advanced cutaneous squamous cell carcinoma or Merkel cell carcinoma who have already tried immunotherapy. T…

This early-stage trial tests a new drug called ONM-501, which is injected directly into tumors, either alone or with the immunotherapy cemiplimab (Libtayo). The study includes 168 adults with advanced solid tumors or lymphomas that have not responded to standard treatments. The m…

This study is testing a device called DaRT that delivers alpha radiation directly into tumors. It is for people with certain skin cancers, mouth cancers, or soft tissue sarcomas that are up to 7 centimeters in size. The goal is to see if the tumors shrink and to check for side ef…

This study tests the immunotherapy drug atezolizumab in 200 people with advanced solid tumors (breast, lung, GI, and others). Researchers use each person's tumor DNA to see if it predicts a response. Participants get the same dose every 3 weeks. The goal is to see if DNA analysis…

This study tests whether a special laser followed by tirbanibulin ointment can effectively treat common skin cancers like basal and squamous cell carcinoma. About 100 adults with biopsy-confirmed skin cancers will receive the laser treatment and, if needed, apply the ointment for…

This study aims to create a detailed database of how healthy, precancerous, and cancerous skin interacts with light. Researchers will collect optical data from 140 patients with skin carcinomas or actinic keratoses. The goal is to identify unique light patterns (spectroscopic sig…

This pilot study is testing whether a handheld laser probe, called Raman spectroscopy, can measure the size of skin cancer tumors. Twenty people with basal or squamous cell carcinoma who are already scheduled for brachytherapy will have their tumors scanned with the probe. The go…

This study is testing whether a telemedicine tool can help primary care doctors find skin cancer earlier. About 1,440 people with suspicious moles or lesions will have their skin checked remotely. The goal is to see if this approach can spot malignancies that might otherwise be m…

This study tests an AI system called Dermalyser that helps primary care doctors decide if a skin spot might be cancer. About 3,000 adults in five countries will take part. Doctors in some clinics will use the AI tool, while others will follow standard care. The goal is to see if …

This study is testing whether an AI-powered smartphone app (NuvanaDx) can accurately detect skin cancer, including melanoma, by analyzing photos of suspicious moles or lesions. About 100 adults with concerning skin spots will take part. The goal is to see if the app can help catc…

This study tests a sun protection program for children playing baseball in rural Utah and West Virginia. Researchers will observe whether kids on teams using the program apply sunscreen, wear hats and long sleeves, and seek shade more often than those on teams that don't. The goa…

This study tests whether a daily application of 5% niacinamide cream can prevent skin cancer in organ transplant recipients, who are at high risk due to long-term immune-suppressing drugs. Twenty adult transplant recipients with a history of precancerous skin spots and at least o…

This pilot study tests whether taking vitamin A and nicotinamide (a form of vitamin B3) can safely raise blood levels in kidney transplant recipients who have had skin cancer. Thirty participants will take these vitamins or a placebo for six months. The goal is to see if this app…

This study looks at whether giving people personalized information about their skin cancer risk can encourage them to protect their skin. About 2,900 adults from community health centers will provide a saliva sample for genetic testing and answer questions about their sun habits.…

This study tests a personalized self-management program to help cancer survivors on immune checkpoint inhibitors better handle side effects and reduce anxiety or depression. About 400 adults with breast, colon, lung, skin, or rectal cancer who recently started immunotherapy will …

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. The goal is to see if the program improves food secur…

This study looks at whether a single dose of meloxicam (a different anti-inflammatory) can control pain better than the usual ibuprofen after Mohs surgery for skin cancer. About 300 adults will be split into three groups, each getting a different pain medicine routine. They will …

This study tests an educational website designed to help people detect skin cancer early. About 280 participants in Singapore will use either a gain-framed or loss-framed version of the program, or no program at all. Researchers will measure how well participants can tell benign …

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study is collecting live tumor samples from 2,000 cancer patients undergoing standard biopsies. Researchers will analyze these samples to understand how tumors respond to immunotherapy drugs outside the body. The goal is to develop a method to predict which patients will res…

This study tests whether a personalized discharge letter helps low-risk skin cancer patients feel more reassured and understand their condition better. About 150 patients will receive either standard advice or a tailored letter generated by an AI system and reviewed by a doctor. …

This study looks at how a laser that makes tiny holes in the skin might help protect against skin cancer. Researchers want to find out where certain skin cells come from after this laser treatment. They are recruiting 12 adults who are already scheduled for tummy tuck surgery to …

This study looks at why some people get sick from heat and sun exposure while others don't. Researchers will monitor 80 healthy volunteers in Denmark and Greece as they undergo controlled heat and UV radiation in a lab. The goal is to develop personalized alerts and advice to hel…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning earlier than standard scans. About 100 people with different solid tumors will give blood samples after treatment. The goal is to see if early detection can lead to better treatm…

This study is tracking 100 people in Slovenia with advanced melanoma who are receiving first-line immunotherapy drugs like pembrolizumab, nivolumab, or ipilimumab. Researchers want to see how well these treatments work and whether a marker called PD-L1 in tumors or blood can pred…

This study looks at how electrochemotherapy—a treatment that uses electric pulses to help chemotherapy drugs enter cancer cells—changes the environment around melanoma skin tumors. Researchers will collect tissue samples from 150 adults before and after treatment to see how immun…

This early-phase trial is testing whether injecting the seasonal flu vaccine directly into skin cancer tumors can boost the immune system's attack on the cancer. About 25 people with cutaneous squamous cell carcinoma will receive one injection into their tumor before standard sur…