SKIN CANCER

This study tests whether adding targeted radiation to a two-drug immunotherapy combination works better than the drugs alone for people with advanced Merkel cell carcinoma, a rare and aggressive skin cancer. About 50 adults with stage IV or recurrent disease will receive either n…

This early study tested a new way of giving three drugs (encorafenib, binimetinib, and nivolumab) to people with advanced BRAF-mutant melanoma. Instead of taking the drugs every day, participants followed an on/off schedule to see if it could control the cancer while reducing sid…

This study tests a device that delivers a special type of radiation (alpha rays) directly into tumors. It is for people with skin, mouth, or soft tissue cancers that have not responded to standard treatments or who cannot have surgery or regular radiation. The goal is to see if t…

This study tests a cream containing sirolimus, applied nightly for 24 weeks, to prevent skin cancer on the face of organ transplant recipients. 146 adults who have had an organ transplant and a past skin cancer are participating. The cream is compared to a placebo to see if it re…

This early-phase study tests a new drug, XL888, added to two existing melanoma drugs (vemurafenib and cobimetinib) for people with advanced BRAF-mutated melanoma that cannot be removed by surgery. The main goal is to find the safest dose of XL888 and see how well the combination …

This study explores a special camera that takes detailed pictures of skin lesions without needing to cut the skin. The goal is to improve early detection of skin cancer and reduce the number of biopsies. Over 1,800 people with skin lesions and healthy volunteers took part. The te…

This study tests a new imaging method called photoacoustic imaging to see skin tumors in 3D. About 200 people with suspected skin cancer will have their tumors scanned before surgery. The goal is to measure tumor thickness and surface size more accurately, which could help surgeo…

This study planned to use online tools like ads and social media to help people avoid skin cancer risks, such as indoor tanning. It was designed for men aged 18 to 65 who use Facebook and are part of the LGBT community. However, the study was withdrawn before any participants wer…

This study asks 3000 adults who had skin cancer surgery to fill out a one-time online survey about how they feel about their appearance, scars, and quality of life. The goal is to understand what matters most to patients after surgery. No new treatments or medications are being t…

This study collects tumor tissue from about 416 people with various advanced cancers to develop and train a new diagnostic platform called Elephas. The goal is to see how accurately the platform can predict whether a patient will respond to immunotherapy, compared to standard met…

This pilot study tests a community-based educational program to raise awareness of melanoma and other skin cancers. About 45 adults in Brooklyn will attend a session led by a health worker and complete surveys and follow-ups over 12 months. The goal is to see if the program impro…