Transplant patients get new hope: sirolimus cream may stop facial cancers

NCT ID NCT05860881

Ongoing Disease control Sponsor: Melanoma and Skin Cancer Trials Limited Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 3 trial tests whether a cream containing sirolimus (rapamycin) can prevent facial skin cancers in people who have received an organ transplant. 146 participants apply the cream or a placebo to their face every night for 6 months. The study counts new skin cancers during treatment and up to 2 years later.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sirolimus (rapamycin) cream
What this could lead to: If it works, this could offer a way to reduce skin cancer risk in organ transplant recipients without needing more surgery.
What could go wrong: This is a phase 3 trial, but results are not yet available. The cream may cause skin irritation or not reduce cancer risk significantly. Transplant recipients already take lifelong immunosuppressants, which may limit the effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

skin cancer skin neoplasm skin squamous cell carcinoma prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SKIN CANCER SOLID ORGAN TRANSPLANT RECIPIENTS

Contacts and locations

Locations

Princess Alexandra Hospital

Woolloongabba, Queensland, 4102, Australia
Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia
Skin Health Institute

Carlton, Victoria, 3053, Australia
The Alfred Hospital

Melbourne, Victoria, 3004, Australia
The Prince Charles Hospital

Chermside, Queensland, 4032, Australia
Westmead Hospital

Westmead, New South Wales, 2145, Australia

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