New combo therapy aims to shrink inoperable skin cancers
NCT ID NCT05574101
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether combining radiation therapy with the immunotherapy drug cemiplimab can effectively treat locally advanced skin cancer that cannot be surgically removed. The study involves 34 participants who will receive both treatments over about 12 months. The main goal is to see how long the cancer stays under control after treatment starts.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cemiplimab (immunotherapy drug) and radiation therapy
- What this could lead to
- If successful, this combination could offer a new, non-surgical treatment option for people with advanced skin cancer that cannot be removed by surgery.
- What could go wrong
- This is a small, early-phase trial with only 34 participants. It is not yet proven to work better than existing treatments, and immunotherapy can cause immune-related side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CUTANEOUS SQUAMOUS CELL CARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cleveland Clinic (Data Collection Only)
Cleveland, Ohio, 44195, United States
-
Fox Chase Cancer Center (Data Collection Only)
Philadelphia, Pennsylvania, 19111, United States
-
Medical University of South Carolina
Charleston, South Carolina, 29425, United States
-
Memorial Sloan Kettering Bergen (All protocol activities)
Montvale, New Jersey, 07645, United States
-
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, 10065, United States
-
Memorial Sloan Kettering Cancer Center at Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey, 07920, United States
-
Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, New Jersey, 07748, United States
-
Memorial Sloan Kettering Nassau (All protocol activities)
Rockville Centre, New York, 11553, United States
-
Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities)
Commack, New York, 11725, United States
-
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, 10604, United States
-
Moffitt Cancer Center (Data Collection Only)
Tampa, Florida, 33612, United States
-
University of Colorado (Data Collection Only)
Aurora, Colorado, 80045, United States
-
University of Washington (Data Collection Only)
Seattle, Washington, 98109, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can Pre-Surgery immunotherapy prime the immune system to fight head and neck cancer?
- Can your genes predict your melanoma risk?
- Glowing cancer cells: a new way to see tumors during surgery?
- A UV photo and a cheek swab may be the keys to stopping sunburn before it starts
- Botox before the knife: could a Pre-Surgery injection lead to Better-Looking scars?
- Night shift workers' skin may struggle to fix sun damage, study suggests