Radioactive seeds plus immunotherapy: a new hope for Hard-to-Treat head and neck cancer?
NCT ID NCT05047094
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial is testing a new approach for people with head and neck cancer that has come back or spread and cannot be removed. It combines a device called DaRT, which is a tiny radioactive seed placed directly into the tumor, with the immunotherapy drug pembrolizumab (Keytruda). The goal is to see if this combination can shrink tumors and control the disease. About 48 participants will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Diffusing Alpha Radiation Emitters Therapy (DaRT) device and pembrolizumab (Keytruda)
- What this could lead to
- If it works, this could offer a new treatment option for people with head and neck cancer that has come back or spread and cannot be removed by surgery.
- What could go wrong
- This is an early-stage trial with only 48 participants, so results may not apply to everyone. The combination of radiation and immunotherapy may cause side effects like inflammation or immune reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sharett institute, Hadassah University Hospital - Ein-Kerem
RECRUITINGJerusalem, 91120, Israel
-
Sheba Medical Center
RECRUITINGRamat Gan, Israel
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Tel-Aviv Medical Center
NOT_YET_RECRUITINGTel Aviv, Israel
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