Could ozone gas soothe cancer Patients' painful mouth sores?

NCT ID NCT07491536

Recruiting now Symptom relief Sponsor: University of Pavia Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether applying medical ozone gas to mouth sores can reduce pain and severity in people undergoing radiation or chemotherapy for head and neck cancer. Fifty participants will receive ozone therapy, and half will also use a special toothpaste and mouthwash at home. The goal is to see if these treatments help people eat, drink, and continue cancer therapy with less discomfort.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: gas ozone therapy
What this could lead to: If it works, this could offer a simple, non-drug way to reduce mouth sore pain and help people continue cancer treatment without delays.
What could go wrong: This is a small, early-stage trial with only 50 people. Ozone therapy is not yet proven for this use, and results may not apply to everyone. Side effects are possible but not well-studied.

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Conditions

The condition(s) this trial relates to.

chemotherapy-induced oral mucositis head and neck neoplasm Head and Neck Neoplasms stomatitis Xerostomia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHEMOTHERAPY INDUCED ORAL MUCOSITIS HEAD AND NECK NEOPLASMS ORAL MUCOSITIS

Contacts and locations

Locations

Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia
RECRUITING

Pavia, Lombardy, 27100, Italy

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