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Olive oil and betaine gel may ease radiation mouth pain

NCT ID NCT05635929

Recruiting now Symptom relief Sponsor: Mucosa Innovations, S.L. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing a topical gel and mouthwash made from olive oil, betaine, and xylitol (XCM-OM118) to see if it can reduce severe oral mucositis (painful mouth sores) in head & neck cancer patients receiving radiation. The study will enroll 63 adults and track how many develop severe sores, as well as measure quality of life using patient questionnaires. The goal is to find a simple, non-drug way to ease a common and painful side effect of cancer treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
XCM-OM118 (a gel and mouthwash made from olive oil, betaine, and xylitol)
What this could lead to
If it works, this could offer a simple, non-drug way to prevent severe mouth sores during radiation, improving quality of life for head & neck cancer patients.
What could go wrong
This is a small, early-phase trial with no control group, so results may not be definitive. The treatment may not reduce severe mucositis as hoped.

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Conditions

The condition(s) this trial relates to.

chemotherapy-induced toxicity head and neck cancer Head and Neck Neoplasms mucositis Pain radiation injury Speech speech disorder stomatitis ulcer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHEMOTHERAPEUTIC TOXICITY HEAD AND NECK CANCER MUCOSITIS ORAL MUCOSITIS PAIN QUALITY OF LIFE RADIATION TOXICITY SALIVA SPEECH

Contacts and locations

Locations

  • Mucosa Innovations S.L.

    RECRUITING

    Madrid, Madrid, 28023, Spain

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