Chemotherapy-induced toxicity

This study is for people with a type of stomach cancer that is H. pylori-positive and can be removed with surgery. It compares standard chemotherapy before and after surgery to the same chemotherapy plus treatment to eliminate H. pylori bacteria. The goal is to see if adding the …

This study tests whether adding all-trans retinoic acid to romiplostim N01 can better raise platelet counts in adults who have low platelets after finishing chemotherapy for gastrointestinal cancers. About 220 participants will receive either the combo or romiplostim alone for 12…

This study is for adults with certain cancers (like breast, lung, or ovarian) that are in complete remission but have persistently low platelet counts from past chemotherapy. It tests whether adding a vitamin A derivative (ATRA) to a standard platelet-boosting drug works better t…

This study tests whether a combination of chemotherapy and radiation (total neoadjuvant therapy, or TNT) can shrink rectal tumors enough so that some patients can avoid surgery and instead be monitored closely. About 400 adults with early-stage rectal cancer will be randomly assi…

This study tests a drug called romiplostim N01 in children, adolescents, and young adults (ages 6-24) with cancer who develop low platelet counts from chemotherapy. The drug is given as a weekly shot to help the body produce more platelets. The goal is to see if it can safely and…

This study tests whether a single injection of Telpegfilgrastim works better than daily Filgrastim shots to prevent fever and low white blood cells in children and young adults (ages 6-24) with solid tumors receiving strong chemotherapy. About 132 participants will receive either…

This study is for adults newly diagnosed with a type of acute myeloid leukemia (non-M3). It tests whether adding silibinin, a natural compound from milk thistle that protects the liver, to standard chemotherapy can improve remission rates and survival. About 100 participants will…

This study looks at whether cancer survivors who had heart problems from their cancer treatment can safely stop taking heart failure medications once their heart function is back to normal. About 335 adults who have finished cancer therapy and are on heart medications will be ran…

This study tests whether dapagliflozin, a drug used for diabetes, can prevent kidney damage caused by platinum-based chemotherapy in people with solid tumors. About 46 participants will receive either dapagliflozin or a placebo for a few days around their chemo session. Researche…

This study tests two treatments for a type of bile duct cancer that cannot be surgically removed. One delivers chemotherapy directly to the liver through a pump, and the other uses tiny radioactive beads injected into the tumor's blood supply. Both are given alongside standard ch…

This pilot study is testing whether giving activated charcoal within 6 hours of swallowing a poisonous substance can prevent the poison from getting worse and shorten hospital stays. About 100 adults and children who have ingested a substance that charcoal can absorb will be rand…

This large phase 3 study is testing different combinations of chemotherapy, radiation, immunotherapy, and targeted drugs given before surgery for esophageal cancer. The goal is to find which approach works best to improve survival. The trial will enroll 2,000 adults with stage I …

This study is looking at the best way to treat esophageal cancer that cannot be removed by surgery. It will follow 2,000 patients who receive chemoradiotherapy (radiation plus chemotherapy) along with possible immunotherapy or targeted drugs. The goal is to see which combinations…

This study tests whether adding chemotherapy to a two-drug combination (camrelizumab and apatinib) helps people with advanced liver cancer live longer without their disease getting worse. About 326 adults with liver cancer that cannot be removed by surgery will participate. The g…

This study tests two different ways to give chemotherapy combined with immunotherapy and a targeted drug for people with advanced liver cancer (BCLC stage C). One group gets standard IV chemo plus the drugs camrelizumab and apatinib. The other group gets the same drugs but with c…

This phase 2 trial tests two immunotherapy drugs, nivolumab and relatlimab, given before surgery for stage II-IIIa bladder cancer. The goal is to see if the combination can eliminate the tumor, allowing patients to keep their bladder instead of having it removed. About 90 partici…

This study tests whether taking an inactivated (killed) form of the bacterium Bacteroides fragilis can prevent diarrhea caused by chemotherapy. The trial will enroll 200 cancer patients about to start chemotherapy regimens known to cause diarrhea. Participants will receive either…

This study tests an Arabic-language AI mobile app designed to support women with breast cancer during chemotherapy. The app monitors symptoms, sends medication reminders, and provides educational content. Researchers will compare 130 women who use the app plus usual care to those…

Chemotherapy often causes nausea and vomiting, which is especially hard for children. This study tests a new IV drug called NEPA (fosnetupitant/palonosetron) to prevent these side effects in kids with cancer. The trial has two parts: first, an open-label phase to find the right d…

This small pilot study tests whether using a hand-held vibration device for just 3 minutes each day can safely reduce nerve pain and numbness in the hands caused by chemotherapy. Sixteen adults who finished chemotherapy at least 60 days ago will try the therapy at home. The main …

This study tests whether a probiotic supplement can help reduce diarrhea and belly discomfort in breast cancer patients taking the drug Abemaciclib. About 80 participants will get either the supplement or a placebo for two months, while also using standard anti-diarrhea medicine.…

This study looks at whether teaching cancer patients about taste changes caused by chemotherapy and giving them self-management tools can help reduce those symptoms and maintain healthy eating. About 400 adults starting chemotherapy will be split into two groups: one gets standar…

This study tests whether taking alpha-lipoic acid, a natural antioxidant, can prevent kidney damage in cancer patients receiving cisplatin chemotherapy. About 50 adults with solid tumors will receive either alpha-lipoic acid or a placebo alongside their chemo. Researchers will mo…

This study tests whether playing a serious game on an iPad can help older adults (60+) better manage nausea and vomiting caused by chemotherapy. About 610 participants will be randomly assigned to play the game or receive usual care. Researchers will track symptom severity, quali…

This study tests whether guided imagery—a relaxation technique using calming mental pictures—can reduce nausea and vomiting caused by chemotherapy in children aged 7 to 18 with cancer. Half of the 40 participants will receive guided imagery plus standard care, while the other hal…

This study tests whether a combination of two drugs (fosrolapitant and palonosetron) can prevent nausea and vomiting in people receiving strong chemotherapy for the first time. About 200 adults with solid tumors will be enrolled. The goal is to see if this treatment helps patient…

This study is testing whether squeezing a stress ball during chemotherapy can help reduce nausea, anxiety, and fatigue in people with stomach cancer. About 52 adults will take part. Researchers will measure their symptoms during treatment to see if this simple, drug-free tool mak…

This study tests whether pressing tiny seeds on specific ear points, combined with a steroid drug (dexamethasone), can prevent or reduce nausea and vomiting caused by chemotherapy in breast cancer patients. About 25 women will receive this treatment before chemo and track their s…

This study tests whether combining ear acupressure (using small seeds on specific ear points) with the steroid dexamethasone can better prevent or reduce nausea and vomiting caused by chemotherapy in pancreatic cancer patients. About 25 participants will receive the treatment bef…

This study tests whether regular massage therapy can improve sleep for children aged 12-21 who are hospitalized for cancer treatment or stem cell transplant. Seventy participants will either receive standard care or a 20-30 minute massage five days a week for three weeks. Sleep w…

This phase 2 trial is testing a topical gel and mouthwash made from olive oil, betaine, and xylitol (XCM-OM118) to see if it can reduce severe oral mucositis (painful mouth sores) in head & neck cancer patients receiving radiation. The study will enroll 63 adults and track how ma…

This study tests whether regular phone or video calls from a trained oncology nurse can help breast cancer patients on CDK inhibitor drugs catch and manage side effects early. About 124 women will be randomly assigned to either standard care or standard care plus structured telen…

This early-stage study tests a new drug called KAN-004 in 21 adults who have diarrhea or colon inflammation from cancer immunotherapy. The main goal is to see if the drug is safe and tolerable. Participants must have a solid tumor and be at least 18 years old.

This early-phase trial tests whether the drug romiplostim can prevent dangerously low platelet levels caused by chemotherapy in children and young adults with newly diagnosed Ewing sarcoma. About 26 participants will receive romiplostim alongside their standard chemotherapy to se…

This study tests whether a computer model can predict vomiting in children with cancer who are in the hospital. The model uses each child's medical information to estimate their risk of vomiting in the next 96 hours. Doctors and pharmacists will use this information to give extra…

This study tests whether a 16-week high-intensity interval training (HIIT) program on a stationary bike can improve thinking, memory, and heart health in women undergoing chemotherapy for breast cancer. Thirty participants will be randomly assigned to either HIIT or a stretching …

This study looks at whether socio-aesthetic care (like skincare and makeup sessions) can lower anxiety in cancer patients who are starting chemotherapy. About 192 people who have never had chemo before will take part. Researchers will measure their anxiety levels before treatment…

This study tests whether a mobile cognitive training app can reduce 'chemobrain'—memory and thinking problems caused by chemotherapy—in people with gynecologic cancers. Sixty-four participants will use the app on their own phones while undergoing chemotherapy and complete thinkin…

This study tests whether a granisetron skin patch works better than ondansetron pills for preventing nausea and vomiting in people getting chemotherapy before a stem cell transplant. About 90 patients will be enrolled and randomly assigned to one of the two treatments. The goal i…

This early-phase trial tests a topical phenylephrine gel applied daily to the scalp for three weeks. Researchers want to see how much of the drug enters the bloodstream and whether it is safe. The study involves 24 healthy women aged 18-55, not cancer patients, so it is a first s…

This study follows 105 adults with chronic pain, nerve damage, or slow wound healing from cancer treatments. They receive ozone therapy as an add-on to their usual care. Researchers track changes in quality of life, anxiety, and depression to see if ozone therapy helps.

This study looks at how a 12-week physical activity program, delivered through smartphone apps and a Fitbit, affects brain function in cancer survivors who report 'chemo-brain' (cognitive problems after chemotherapy). Researchers will compare survivors with and without type 2 dia…

This pilot study looks at whether changes in gut bacteria are linked to fatigue and nausea in women with early-stage breast cancer undergoing chemotherapy. Researchers will collect stool and blood samples and have participants fill out questionnaires before and after treatment. T…

This study explores whether cancer patients can safely monitor their own blood counts at home during chemotherapy. About 265 participants from Denmark, Poland, and Germany will test a home monitoring device for several cycles. The goal is to reduce unnecessary hospital visits, lo…