New IV combo aims to stop chemo sickness in kids
NCT ID NCT06904235
First seen Apr 13, 2026
Summary
Chemotherapy often causes nausea and vomiting, which is especially hard for children. This study tests a new IV drug called NEPA (fosnetupitant/palonosetron) to prevent these side effects in kids with cancer. The trial has two parts: first, an open-label phase to find the right dose and check safety, then a double-blind phase comparing NEPA to standard anti-nausea drugs. About 95 children from birth to under 18 years old will take part.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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"AHEPA" University General Hospital of Thessaloniki, 2nd Department of Pediatrics
RECRUITINGThessaloniki, Greece
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Aghia Sophia Children's Hospital, Pediatric Hematology/ Oncology Unit (POHemU)
RECRUITINGAthens, Greece
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Ankara University Faculty of Medicine Children's Hospital, Department of Children Oncology and Hematology
RECRUITINGAnkara, Mamak, Turkey (Türkiye)
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Clinic of Pediatrics, Oncology and Hematology University Pediatric Center them M. Konopnicka SP ZOZ Central Clinical Hospital Medical University of Lodz
RECRUITINGLodz, Poland
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Clinical Department of Paediatric Oncology and Haematology VOIVODSHIP SPECIALIST CHILDREN'S HOSPITAL them. prof. dr. Stanisław Popowski in Olsztyn
WITHDRAWNOlsztyn, Poland
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Department of Oncology Institute "Monument - Child Health Center"
RECRUITINGWarsaw, Poland
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Department of Oncology and Surgical Oncology for Children and Youth Institute Mother and Child
RECRUITINGWarsaw, Poland
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Department of Paediatrics and Paediatric Haemato-Oncology University Clinical Hospital No. 1 them. prof. Tadeusz Sokołowski Pomeranian Medical University
WITHDRAWNSzczecin, Poland
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Department of Paediatrics, Haematology, Oncology and Rheumatology Voivodship Children's Hospital them. J. Brudziński
RECRUITINGBydgoszcz, 85-667, Poland
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Department of Paediatrics, Oncology and Paediatric Immunology, University Clinical Hospital No. 1 them. prof. Tadeusz Sokołowski Pomeranian Medical University in Szczecin
RECRUITINGSzczecin, Poland
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Department of Pediatric Oncology, Hematology and Transplantation Clinical Hospital them. Karol Jonscher Medical University them. Karol Marcinkowski in Poznań
RECRUITINGPoznan, Poland
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Department of Pediatrics, Oncology and Hematology University Children's Clinical Hospital them. Ludwik Zamenhof in Bialystok
WITHDRAWNBialystok, Poland
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Emergency Children's Hospital " Louis Turcanu, Oncology-Haematology and BMP department
RECRUITINGTimișoara, Romania
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Erciyes University Hospitals Kanka Children's Hematology Oncology and Bone Marrow Hospital
RECRUITINGKayseri, Melikgazi, Turkey (Türkiye)
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Fundeni Clinical Institute, Pediatric Hematology and BMT
RECRUITINGBucharest, Romania
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Gazi University Gazi Hospital Children Hematology and Oncology
RECRUITINGAnkara, Turkey (Türkiye)
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Hacettepe University Hospitals Oncology Hospital 2nd Floor Children Oncology
RECRUITINGAnkara, Turkey (Türkiye)
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Istanbul University Istanbul Faculty of Medicine Topkapı
NOT_YET_RECRUITINGIstanbul, Faith, Turkey (Türkiye)
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Oncology Institute "Prof. Dr. Al. Trestioreanu", Pediatric Oncology
RECRUITINGBucharest, Romania
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University Children'S Hospital in Lublin, Department of Pediatric Hematology, Oncology, and Transplantology
NOT_YET_RECRUITINGLublin, 20-093, Poland
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
IV NEPA (fosnetupitant/palonosetron)
What this could lead to
If successful, this could provide a more effective way to prevent chemotherapy-induced nausea and vomiting in children, improving their quality of life during cancer treatment.
What could go wrong
This is an early-phase study with only 95 participants, so results may not apply to all children. The drug may cause side effects or not work better than existing treatments.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.