New IV combo aims to stop chemo sickness in kids

NCT ID NCT06904235

Recruiting now Symptom relief Sponsor: Helsinn Healthcare SA Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

Chemotherapy often causes nausea and vomiting, which is especially hard for children. This study tests a new IV drug called NEPA (fosnetupitant/palonosetron) to prevent these side effects in kids with cancer. The trial has two parts: first, an open-label phase to find the right dose and check safety, then a double-blind phase comparing NEPA to standard anti-nausea drugs. About 95 children from birth to under 18 years old will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: IV NEPA (fosnetupitant/palonosetron)
What this could lead to: If successful, this could provide a more effective way to prevent chemotherapy-induced nausea and vomiting in children, improving their quality of life during cancer treatment.
What could go wrong: This is an early-phase study with only 95 participants, so results may not apply to all children. The drug may cause side effects or not work better than existing treatments.

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Conditions

The condition(s) this trial relates to.

cancer chemotherapy-induced toxicity Nausea Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NAUSEA AND VOMITING CHEMOTHERAPY-INDUCED NAUSEA POST CHEMOTHERAPY

Contacts and locations

Locations

"AHEPA" University General Hospital of Thessaloniki, 2nd Department of Pediatrics
RECRUITING

Thessaloniki, Greece
Aghia Sophia Children's Hospital, Pediatric Hematology/ Oncology Unit (POHemU)
RECRUITING

Athens, Greece
Ankara University Faculty of Medicine Children's Hospital, Department of Children Oncology and Hematology
RECRUITING

Ankara, Mamak, Turkey (Türkiye)
Clinic of Pediatrics, Oncology and Hematology University Pediatric Center them M. Konopnicka SP ZOZ Central Clinical Hospital Medical University of Lodz
RECRUITING

Lodz, Poland
Clinical Department of Paediatric Oncology and Haematology VOIVODSHIP SPECIALIST CHILDREN'S HOSPITAL them. prof. dr. Stanisław Popowski in Olsztyn
WITHDRAWN

Olsztyn, Poland
Department of Oncology Institute "Monument - Child Health Center"
RECRUITING

Warsaw, Poland
Department of Oncology and Surgical Oncology for Children and Youth Institute Mother and Child
RECRUITING

Warsaw, Poland
Department of Paediatrics and Paediatric Haemato-Oncology University Clinical Hospital No. 1 them. prof. Tadeusz Sokołowski Pomeranian Medical University
WITHDRAWN

Szczecin, Poland
Department of Paediatrics, Haematology, Oncology and Rheumatology Voivodship Children's Hospital them. J. Brudziński
RECRUITING

Bydgoszcz, 85-667, Poland
Department of Paediatrics, Oncology and Paediatric Immunology, University Clinical Hospital No. 1 them. prof. Tadeusz Sokołowski Pomeranian Medical University in Szczecin
RECRUITING

Szczecin, Poland
Department of Pediatric Oncology, Hematology and Transplantation Clinical Hospital them. Karol Jonscher Medical University them. Karol Marcinkowski in Poznań
RECRUITING

Poznan, Poland
Department of Pediatrics, Oncology and Hematology University Children's Clinical Hospital them. Ludwik Zamenhof in Bialystok
WITHDRAWN

Bialystok, Poland
Emergency Children's Hospital " Louis Turcanu, Oncology-Haematology and BMP department
RECRUITING

Timișoara, Romania
Erciyes University Hospitals Kanka Children's Hematology Oncology and Bone Marrow Hospital
RECRUITING

Kayseri, Melikgazi, Turkey (Türkiye)
Fundeni Clinical Institute, Pediatric Hematology and BMT
RECRUITING

Bucharest, Romania
Gazi University Gazi Hospital Children Hematology and Oncology
RECRUITING

Ankara, Turkey (Türkiye)
Hacettepe University Hospitals Oncology Hospital 2nd Floor Children Oncology
RECRUITING

Ankara, Turkey (Türkiye)
Istanbul University Istanbul Faculty of Medicine Topkapı
NOT_YET_RECRUITING

Istanbul, Faith, Turkey (Türkiye)
Oncology Institute "Prof. Dr. Al. Trestioreanu", Pediatric Oncology
RECRUITING

Bucharest, Romania
University Children'S Hospital in Lublin, Department of Pediatric Hematology, Oncology, and Transplantology
NOT_YET_RECRUITING

Lublin, 20-093, Poland

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