Blood test may one day personalize drug dosing after stem cell transplants
NCT ID NCT04160390
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This study collects blood and stool samples from people receiving a donor stem cell transplant to understand how their bodies process the drug cyclophosphamide. By identifying biomarkers, researchers hope to develop a blood test that could predict how well a patient will respond to the drug. The study includes 72 participants with various cancers or nonmalignant diseases who are scheduled for a haploidentical transplant and will receive cyclophosphamide after transplant.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- blood and stool sample collection for biomarker analysis
- What this could lead to
- If successful, this could lead to a blood test that helps doctors personalize cyclophosphamide dosing after stem cell transplants, potentially reducing side effects and improving outcomes.
- What could go wrong
- This is an early biomarker study, not a treatment trial. It may not identify useful biomarkers, and any future blood test would require much larger studies to validate.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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City of Hope Medical Center
Duarte, California, 91010, United States
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