Biopsy DNA clues could spare esophageal cancer patients from futile chemo
NCT ID NCT06490003
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study investigates whether DNA methylation patterns in tumor biopsy samples can predict how well esophageal cancer patients will respond to chemotherapy. Researchers aim to develop a model that identifies patients unlikely to benefit from standard chemo drugs like Fluorouracil and Cisplatin. The study enrolls 150 adults with esophageal squamous cell carcinoma who are receiving their first round of chemotherapy. If the model works, it could help personalize treatment and avoid ineffective therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fluoro Uracil (Cisplatin)
- What this could lead to
- If successful, this could help doctors quickly identify which esophageal cancer patients won't benefit from standard chemotherapy, allowing them to explore alternative treatments sooner.
- What could go wrong
- This is an early-stage model development study with 150 participants. The DNA methylation prediction method may not prove accurate enough for clinical use, and results may not apply to all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Yamanashi Universiy
RECRUITINGChūō, Yamanashi, 4093898, Japan
Contact Email: •••••@•••••
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