Chemotherapy-induced toxicity

This study tests whether taking vitamin C and coenzyme Q10 can prevent kidney damage in cancer patients receiving cisplatin chemotherapy. About 75 adults with various cancers who have not had chemo before will take these supplements alongside their treatment. The goal is to see i…

This pilot study tests whether a daily grape polyphenol concentrate can reduce heart damage in women receiving certain chemotherapies for breast cancer. 120 women at high risk of heart problems will take either the supplement or a placebo for three months. Researchers will measur…

This study tests a daily pill called hetrombopag to see if it can safely raise low platelet counts in women with gynecological cancers (like ovarian or cervical cancer) after chemotherapy. About 244 women whose platelets dropped too low will take the drug to help them complete th…

This Phase 2 trial tests whether combining two platelet-boosting drugs (hetrombopag and rhTPO) works better than hetrombopag alone for cancer patients with dangerously low platelets from treatment. About 204 adults with solid tumors will be randomly assigned to one of the two gro…

This study tests whether the drug hetrombopag can prevent severe low platelet counts caused by chemotherapy in people with nasopharyngeal carcinoma. About 35 patients who already had low platelets during a previous chemo cycle will take hetrombopag tablets daily during their next…

This study tests a drug called hetrombopag to see if it can prevent or reduce low platelet counts caused by antibody-drug conjugate (ADC) chemotherapy in breast cancer patients. The trial will include 72 adults aged 18-75. Researchers will measure how many patients develop severe…

This study tests a drug called Romiplostim N01 in 106 cancer patients whose platelets drop due to chemo, radiation, or immunotherapy. The goal is to see if it can safely raise platelet counts better than the current standard treatment. Patients will be randomly assigned to receiv…

This study looks at whether advanced heart tests and blood markers can find early signs of heart damage in children who had chemotherapy or chest radiation for cancer. About 100 survivors aged 2 to 25 will undergo special echocardiograms, exercise tests, and wear activity monitor…

This study will test whether a 12-week program of supervised aerobic and strength exercises can prevent heart problems in 60 adults undergoing chemotherapy for cancer. Participants will be split into an exercise group and a usual-care group. Researchers will measure heart functio…

This study tests whether taking S-adenosylmethionine (SAMe), a natural supplement, can prevent liver injury caused by the chemotherapy drug oxaliplatin. About 30 adults with colorectal cancer that has spread to the liver will take SAMe pills daily for 3-6 months alongside their c…

This study tests a new treatment called DA-020 to prevent hair loss in people with early-stage breast cancer receiving chemotherapy. About 60 participants will use DA-020 during their chemo sessions. The goal is to see if it can reduce hair loss and help hair grow back faster aft…

This study tests if a special light (photobiomodulation) can prevent and treat painful mouth sores caused by chemotherapy in children aged 4-17 with cancer. Half of the 49 participants will get light therapy, and the other half will get a standard gel. The goal is to see if the l…

This study tests whether foot reflexology, a gentle foot massage technique, can help reduce nausea and vomiting caused by chemotherapy in breast cancer patients. Fifty women receiving chemotherapy will be split into two groups: one gets standard care plus foot reflexology, the ot…

This study tests whether adding acupuncture to standard care can lower the risk of hospital stays for a serious chemo side effect called febrile neutropenia (fever with low white blood cells). About 60 adults with sarcoma receiving doxorubicin chemotherapy will be randomly assign…

This Phase 2 trial tests an oral drug called AND017 for cancer-related anemia caused by chemotherapy. About 36 adults with non-myeloid cancers and low hemoglobin will take AND017 three times a week for 6 weeks. The goal is to see if it safely raises hemoglobin levels and reduces …

This study tests a new form of the drug megestrol acetate (nano-crystalline) combined with a standard anti-nausea medicine to prevent nausea and vomiting caused by chemotherapy. It involves 127 people with stomach cancer who are starting their first chemotherapy. The goal is to s…

This study tests a highly absorbable form of curcumin (from turmeric) in 72 adults with mid-to-low rectal cancer who are getting chemoradiation before surgery. The goal is to see if curcumin can reduce severe gut side effects like diarrhea and rectal pain. Researchers will also c…

This study tests whether a probiotic called Clostridium butyricum can reduce severe diarrhea and other side effects in people getting chemotherapy for colorectal cancer. About 238 adults who had surgery for colorectal cancer and need chemo will take either the probiotic or a plac…

This early-stage study tests a drug called DA-020 in 60 healthy women aged 18-55. The goal is to measure how much of the drug enters the blood after one application to the scalp and to check for side effects like blood pressure changes. This research helps understand the drug's s…

This study looks at how often women with early-stage breast cancer experience taste changes during chemotherapy. Researchers will use taste tests to measure changes in sweet, sour, salty, and bitter perception. They will also check how these changes affect nutrition and quality o…

This study looks at 38 women who had pelvic side effects (like pain in the rectum, bladder, or vagina) after radiation or chemotherapy for gynecological cancers. Researchers will compare their gut bacteria to healthy controls and see if rectal ozone therapy changes the microbiome…

This study will check if certain blood markers can predict heart damage in children and teens who had anthracycline chemotherapy for cancer. Researchers will compare blood tests and heart imaging results from 40 survivors and healthy volunteers. The goal is to find early warning …