Could ozone therapy soothe pelvic pain by changing gut bacteria?

NCT ID NCT07259681

Not yet recruiting Knowledge-focused Sponsor: Bernardino Clavo, MD, PhD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 38 women who had pelvic side effects (like pain in the rectum, bladder, or vagina) after radiation or chemotherapy for gynecological cancers. Researchers will compare their gut bacteria to healthy controls and see if rectal ozone therapy changes the microbiome and eases symptoms. The goal is to understand why some women get severe, lasting side effects and how ozone might help.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: rectal ozone therapy
What this could lead to: If successful, this study could reveal how gut bacteria relate to pelvic side effects from cancer treatment and whether ozone therapy works by changing the microbiome, pointing toward better management strategies.
What could go wrong: This is a small, early observational study (38 people) that does not test a new treatment directly. It may only show associations, not cause and effect, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

chemotherapy-induced toxicity Dysbiosis female reproductive organ cancer female reproductive system neoplasm mucositis radiation cystitis radiation injury radiation proctitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHEMOTHERAPY TOXICITY DYSBIOSIS GYNECOLOGICAL TUMORS PELVIC TOXICITY QUALITY OF LIFE RADIATION CYSTITIS RADIATION PROCTITIS RADIATION TOXICITY VAGINAL MUCOSITIS VULVAR MUCOSITIS

Contacts and locations

Locations

Hospital Universitario de Gran Canaria Dr. Negrín, (FIISC)

Las Palmas de Gran Canaria, Las Palmas, 35019, Spain
Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias - Universidad de La Laguna

San Cristóbal de La Laguna, Tenerife, 38296, Spain

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