Speech disorder

This study is testing whether a cochlear implant is safe and effective for infants and toddlers who are deaf in one ear. Sixty children will receive the implant and be followed until age 5. Researchers will compare their hearing abilities to children with normal hearing and to th…

This early study tests a brain-computer implant that reads brain signals to help people with severe paralysis (from ALS, stroke, or spinal cord injury) communicate. The device aims to decode imagined speech and allow control of computers. Only 2 participants will be enrolled to c…

This trial tests a structured, 8-session program designed to help adults who stutter feel less anxious and more confident in job interviews. The program uses techniques like cognitive restructuring, voluntary stuttering, and simulated interviews to gradually reduce fear of negati…

This study tests whether low-intensity focused ultrasound (LIFU), a gentle sound wave technique, can safely improve speech fluency in people who stutter. Twenty adults who stutter will receive LIFU or a sham treatment, and researchers will measure changes in stuttering severity a…

This pilot study tests whether repeated transcranial magnetic stimulation (rTMS) can reduce stuttering in adults. Two participants will receive 10 rTMS sessions, and researchers will measure changes in brain activity and speech. The goal is to see if this non-invasive treatment c…

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 kids will be randomly assigned to one of three delivery methods. The goal is to find out which approach impro…

This phase 2 trial is testing whether the drug lumateperone can reduce stuttering symptoms in adults with moderate to severe childhood-onset stuttering. Participants take either lumateperone (21 mg or 42 mg) or a placebo daily for several weeks. Researchers will measure changes i…

This pilot study tests whether the Voiceitt app can help people with speech impairments caused by conditions like cerebral palsy, stroke, ALS, or Parkinson's disease communicate more effectively. Participants use the app to see if it improves speech clarity and daily communicatio…

This study tests a speech therapy program for bilingual Spanish-English or Spanish-Catalan speakers with primary progressive aphasia, a condition that slowly damages language abilities. Sixty participants will receive personalized script training via video sessions, while 30 othe…

This study tests whether home-based video games can improve speech clarity and arm movement in children with cerebral palsy. Fifteen children aged 8-17 will play specially designed computer games for 30 minutes a day, 5 days a week, for 8 weeks. Researchers will measure changes i…

This study is testing whether speech amplification devices can help people with Parkinson's disease and related conditions who have a soft, weak voice (hypophonia). Researchers will work with 100 participants to measure how well these devices improve speech loudness, clarity, and…

This study tests whether virtual reality (VR) games can make speech therapy more fun and improve how often people practice. Researchers will enroll 30 adults with voice disorders at the Glenrose Rehabilitation Hospital. Participants will use VR speech therapy games at home and in…

This study is testing whether a web-based platform called Cognishine can help adults with cognitive and speech problems after a brain injury or stroke. Instead of using paper exercises, patients will do therapy on a tablet or computer. The goal is to see if this digital approach …

Some head and neck cancer survivors develop velopharyngeal dysfunction (VPD), where the soft palate doesn't close properly, causing nasal-sounding speech and trouble swallowing. This study tests a simple injection that plumps up the back of the throat to improve closure. Research…

This small study from Stanford tests whether rapid, non-invasive brain stimulation can reduce the urge to hoard. Ten adults with hoarding disorder will receive the treatment and report changes in their acquiring habits. The goal is to see if this safe, outpatient procedure can ea…

This study tests whether a safe, noninvasive brain stimulation technique called HD-tDCS can reduce stuttering symptoms like repetitions and blocks. Fifty adults who stutter will receive a single session of stimulation and complete speaking tasks before and after. The goal is to s…

This phase 2 trial is testing a topical gel and mouthwash made from olive oil, betaine, and xylitol (XCM-OM118) to see if it can reduce severe oral mucositis (painful mouth sores) in head & neck cancer patients receiving radiation. The study will enroll 63 adults and track how ma…

This study tests whether virtual reality (VR) simulations can help college students improve their public speaking skills and reduce anxiety. 80 students will be randomly assigned to either a VR training group or a wait-list control group. Researchers will measure speech rate, pau…

This study tests whether a gentle brain stimulation technique (tDCS) combined with standard speech therapy can reduce stuttering severity and its negative impact on daily life. Sixteen adults who stutter will receive both treatments, and researchers will measure changes in speech…

This study tests a new approach to help children ages 7 to 11 who have trouble saying the /s/ sound (like in "snake"). Participants will do very short 10-minute speech lessons over video chat four times a week for eight weeks. The goal is to see if these brief, frequent sessions …

This study tests whether a gentle, noninvasive electrical current applied to the scalp can improve speech fluency in adults who stutter. Researchers will give 80 participants three sessions of brain stimulation while they read aloud, then measure changes in brain activity and stu…

This study follows 1,000 children who have surgery for a brain tumor in the back part of the brain. Up to 1 in 4 of these children develop a condition called Cerebellar Mutism Syndrome, where they lose the ability to speak. Researchers want to understand why this happens and how …

This study looks at how the brain processes and controls speech in healthy adults. Researchers want to understand how people notice their own speech mistakes and learn new sounds. About 117 English-speaking adults with normal hearing and no neurological conditions will take part.…

This study looks at how the brain uses feedback to control speech in 90 adults aged 18-50, including people who stutter, have dyslexia, and those with typical speech. Participants will do speech tasks, have an MRI scan, and receive mild brain stimulation to see how different brai…

This study aims to understand how the brain learns and remembers new ways of speaking. Researchers will use brain scans (fMRI) and magnetic pulses (TMS) to see which brain areas are involved. 50 healthy, right-handed, fluent English speakers with normal hearing will participate. …

This study looks at how men and women differ in voice quality after having their voice box removed (total laryngectomy) and using a special voice prosthesis. Researchers will ask 12 participants to complete surveys and voice tests. The goal is to understand if women have poorer s…

This study looks at how jaw surgery affects speech in people with bite problems like open bite or underbite. Researchers will record patients' speech and tongue movements before and after surgery to see what changes. The goal is to understand why many jaw surgery patients have sp…

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…

This study uses brain scans (fMRI) to compare brain activity when adults who stutter produce stuttered versus non-stuttered speech. Researchers aim to understand which brain circuits are involved. Fifty adults aged 18-65 who stutter will participate. This is not a treatment study…

This study collects medical information and samples from people with hearing, balance, taste, smell, voice, speech, or language disorders. Researchers aim to use this data for future studies and to find candidates for other research. Participants receive standard care, and no exp…

This study follows 120 children aged 3-6 who stutter or have typical speech, to learn why some recover naturally. Kids complete speech tests, wear brain-monitoring caps, and speak in virtual reality classrooms. Researchers track brain activity, heart rate, and skin responses to f…

This study looks at 60 adults with severe hoarding disorder who are already in contact with social services in Copenhagen. Researchers want to find out how many also have other serious mental health conditions and test a new approach: a team of doctors and social workers who reac…

This study looks at how two brain areas—the subthalamic nucleus and the ventral intermediate nucleus of the thalamus—help us learn and produce speech. Researchers will temporarily turn deep brain stimulation (DBS) on or off in 80 people with Parkinson's disease or essential tremo…

This study investigates whether brain surface recordings can decode Mandarin Chinese speech, including tones, from imagined speech. About 50 participants with brain tumors or epilepsy will have temporary electrodes placed during surgery, and 10 people with severe speech loss will…

This observational study looks at how acquired brain injury affects speech and breathing in adults with dysarthria. About 100 participants will have their voice recorded and take breathing tests. The goal is to find better ways to identify the severity and type of dysarthria, hel…

This study explores how the brain learns and remembers speech movements. Researchers will have 330 healthy adults say words while hearing their own voice slightly altered through headphones. The goal is to understand which brain areas help us adapt and retain new speech patterns,…

This study looks at how the brain learns and remembers new ways of speaking. Researchers will use brain stimulation and brain scans in 160 healthy adults to see which brain areas are important for speech motor learning and retention. The goal is to better understand the basic sci…

This study aims to understand which parts of the brain help us learn and remember new ways of speaking. Researchers will use brain scans and magnetic pulses to observe brain activity in 120 healthy adults. The goal is to learn more about how speech motor learning works, not to te…

This study tests a brain implant that reads signals from the brain to help people who have lost the ability to speak fluently communicate through a computer just by trying to talk. It involves up to 2 participants with conditions like spinal cord injury or ALS. The main goal is t…

This study looks at how children who stutter perform on rhythm tasks compared to children who don't stutter. Researchers will test rhythm perception and production once a year for three years in 500 children. The goal is to understand how rhythm skills might be linked to brain ac…

This study gives aripiprazole, a drug that affects dopamine, to 40 adults who stutter to see how it changes brain activity during speech. Researchers use brain scans and audio recordings to measure how the brain processes sound before and during speaking. The goal is to better un…

This study looks at how children who stutter process speech sounds compared to children who do not stutter. Researchers will use hearing tests, brain wave recordings (EEG), and brain scans (fMRI) to measure brain activity. The goal is to understand the differences in speech proce…

This study looks at how a new type of partial denture made from titanium using digital design and milling affects speech. Twelve people with missing teeth will get these dentures, and researchers will measure how clear and understandable their speech is. The goal is to see if tit…