Mental disorder

This trial is testing whether an experimental oral medication called SEP-363856 (ulotaront) can reduce anxiety symptoms in adults with generalized anxiety disorder (GAD). About 384 participants will receive either the drug or a placebo daily for 8 weeks. The main goal is to see i…

This trial tests whether digital follow-up through a patient portal and exercise app can help people with mental disorders stick to a 12-week high-intensity interval training program. Participants will be randomly assigned to receive either digital follow-up or standard care, wit…

This trial tests whether an internet-based form of cognitive behavior therapy (CBT) can reduce symptoms of common mental disorders like anxiety, depression, and stress-related conditions in adults seeking primary care. About 500 participants will be randomly assigned to either th…

This pilot study tests whether a non-invasive brain stimulation technique called tACS can help teens (ages 12-18) with major depression when added to their usual medication. Thirty participants will receive either real or sham stimulation daily for several weeks. The goal is to s…

This study tests whether a combination drug called OLZ/SAM (olanzapine plus samidorphan) causes less weight gain than olanzapine alone in teenagers with schizophrenia or bipolar I disorder. About 220 teens aged 10-17 will take either the combo or olanzapine for 52 weeks. The main…

This early-stage study tests a new drug called VV119 in healthy adults and people with schizophrenia. The main goal is to check if the drug is safe and how the body processes it. About 40 participants will take multiple doses to find the right amount for future studies.

This trial is testing the safety of a medication called lumateperone in children and teenagers who have schizophrenia, bipolar disorder, or autism spectrum disorder. Participants take the drug once daily for 26 weeks, and researchers monitor for side effects. The goal is to see i…

This study is checking the long-term safety of a drug called KarXT in teenagers (13-17) with schizophrenia, and a combination of KarXT and KarX-EC in children (5-17) with irritability linked to autism. About 400 participants who completed earlier studies will take the drug for up…

This study tests whether a gentle electrical current applied to the scalp during reading lessons can improve reading skills in children aged 7 to 17 with dyslexia or reading difficulties. Half the participants receive active stimulation, while the other half receive a sham (place…

This trial tests whether combining aerobic exercise with a targeted reading therapy, called Phono-Motor Therapy, can improve reading skills in people who have reading difficulties after a stroke. Participants will receive both interventions, and researchers will measure changes i…

This phase 3 trial is testing whether the drug KarXT can safely and effectively treat schizophrenia in adolescents aged 13 to 17. About 166 teens will receive either KarXT or a placebo, and researchers will track changes in symptoms like delusions and social withdrawal. The goal …

This trial is testing whether an integrated care pathway (ICP) can help reduce depressive symptoms in adolescents aged 13 to 18 who seek help at community mental health agencies. Participants will receive either the ICP or treatment as usual, and researchers will track changes in…

This study is testing a new drug called ML-007C-MA for adults with schizophrenia. The goal is to see if it is safe and works well over a full year. About 500 people who have recently been in a related study or are new to the trial will take the drug twice daily. Researchers will …

This phase 3 trial is testing whether an experimental oral medication called SEP-363856 (ulotaront) can reduce anxiety symptoms in adults with generalized anxiety disorder. Participants will receive one of two fixed doses of the drug or a placebo for 8 weeks. The main goal is to …

This trial is testing whether esketamine nasal spray, when added to a person's usual antidepressant, can help adults with major depression who haven't improved after trying two or more medications. Participants will receive supervised esketamine treatments over several weeks and …

This study compares obstacle course training and neuromotor task training in 28 children aged 7-10 with developmental coordination disorder (DCD). Both programs run twice a week for 9 weeks and aim to improve motor planning and functional mobility. Researchers will measure skills…

This trial tests whether adding two 'chronotherapeutics'—bright light therapy in the morning and a slow-release melatonin pill at night—to standard antidepressants can better ease depression in adults who also have insomnia. About 184 people with major depression and sleep proble…

This study compares a new, lower-energy seizure therapy (LAP-ST) to standard electroconvulsive therapy (ECT) for quickly reducing suicidal thoughts in people with depression, bipolar disorder, or schizoaffective disorder. The goal is to see if the gentler approach works just as w…

This study tests whether combining two types of stimulation—one that targets a nerve in the ear (or a surgically implanted neck device) and another that uses magnetic pulses on the scalp—can better relieve symptoms of treatment-resistant depression. Participants attend six treatm…

This trial tests whether adding metacognitive training—exercises that help people think about their own thinking—to standard word-finding rehabilitation can improve language skills in people with chronic aphasia after a stroke. The study involves 18 participants who will receive …

This trial investigates whether combining two medications—reboxetine and methylphenidate—can reduce PTSD symptoms by improving attention and emotional regulation. Adults with PTSD will receive either the drug combination or a placebo for about a month, and researchers will measur…

This trial tests whether heart rate variability biofeedback (HRVB) — a technique that uses guided breathing to improve the body's stress response — can help veterans with both PTSD and substance use disorder. Participants will be randomly assigned to receive either HRVB or presen…

This trial tests whether methylphenidate, a standard ADHD medication, can reduce attention and hyperactivity problems in children and adolescents with KBG syndrome, a rare genetic condition often accompanied by ADHD-like symptoms. Participants receive alternating blocks of the dr…

This study tests a program called LAGOM designed to improve heart health and quality of life for people with psychotic disorders. 644 adults from six clinics in Gothenburg will either receive the LAGOM program or standard care. The program includes regular check-ups, motivational…

This study tests whether a single dose of psilocybin, taken with psychological support, can ease symptoms of major depression. It also explores whether adding a non-invasive device that gently stimulates the ear—called transcutaneous auricular vagus nerve stimulation—can boost or…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This phase 2 trial is testing whether an experimental tablet called ALKS 7290 can reduce ADHD symptoms in adults. About 312 adults with ADHD will take either the drug or a placebo daily for 4 weeks. Researchers will measure changes in symptom scores and watch for side effects to …

This study tests whether a computerized training program designed to improve response inhibition — the ability to stop an automatic action — can reduce symptoms in people with obsessive-compulsive disorder, trichotillomania (hair-pulling), or skin-picking disorder. Participants a…

This study tests whether adding the diabetes drug metformin to standard antidepressants helps people with both depression and obesity lose weight and feel better. Researchers will also check if certain gene variants affect how well the combination works. The trial involves 200 ad…

This study follows 300 adults with Parkinson's disease, essential tremor, or dystonia who receive deep brain stimulation (DBS). DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement. Researchers will track symptom severity, medicat…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This trial tests whether a 12-session healthy lifestyle program—focusing on physical activity, nutrition, sleep, and stress management—can lower cardiovascular risk in adults with posttraumatic stress disorder (PTSD). Participants are adults with PTSD symptoms who are also overwe…

This study tests whether adding brenipatide to standard schizophrenia medication is safe and effective. About 450 adults with schizophrenia will receive either brenipatide or a placebo for up to 12 months. The study looks at weight changes, cognitive function, and time to relapse…

This study tests whether adding a new drug called brenipatide to standard depression treatment can delay the return of major depressive symptoms. About 1000 adults with major depression who are already on stable medication will receive either brenipatide or a placebo as a shot, p…

This trial compares two parenting programs for caregivers who have depression and are seeking help for their child's emotional or behavioral difficulties. The experimental program, ADAPT, is designed to address the unique emotional needs of depressed parents, while the control is…

This study tests whether adding the drug brenipatide to standard treatment can delay the return of bipolar symptoms compared to a placebo. About 400 adults with bipolar I or II will self-inject the study drug or placebo for at least 6 months. The main goal is to see how long it t…

This trial tests whether a brief, individually tailored parent training program—just three sessions with optional boosters—can reduce behavioral difficulties in children aged 2 to 12, compared to usual care. Parents of children referred to mental health centers are randomly assig…

This study tests whether combining yoga with a mild electrical brain stimulation technique, called tDCS, can improve thinking and memory in people with psychosis. Participants will be randomly assigned to receive either active tDCS during yoga or a sham (inactive) version, and re…

This trial tests whether a single dose of levetiracetam, a drug used for epilepsy, can reduce overactivity in the hippocampus — a brain area linked to thinking and memory problems in psychosis. People aged 18–40 who are at risk of psychosis will take either the drug or a placebo …

This study tests whether adding cognitive behavioral therapy (CBT) can help children and teens with obsessive-compulsive disorder (OCD) safely stop their medication without symptoms returning. Participants first receive CBT for 12 to 18 weeks, then continue with maintenance sessi…

This expanded access program offers continued treatment with OLZ/SAM, a combination of olanzapine and samidorphan, to adolescents with schizophrenia or bipolar I disorder who have already completed a year-long study of the drug. The goal is to provide ongoing access to the medica…

This trial investigates whether combining repetitive transcranial magnetic stimulation (rTMS) with aerobic exercise can treat depression and improve walking in people who have had a stroke. Participants will receive either real or sham rTMS along with exercise sessions over 12 we…

This study tests whether deep brain stimulation (DBS) can safely treat severe, treatment-resistant bipolar depression. The approach uses a brain implant that delivers stimulation and simultaneously monitors brain signals linked to depression and mania. The goal is to see if this …

This trial tests whether two different eating plans—time-restricted eating (eating within a 10-hour window each day) and a Mediterranean diet—can help people with bipolar disorder. Participants will track their eating, sleep, and mood for two weeks, then follow one of the diets f…

This study tests whether combining aerobic exercise with computerized cognitive training, both delivered via telehealth, can improve thinking and motivation in people who have recently experienced a first episode of schizophrenia. About 100 participants will receive cognitive tra…

This study tests whether the diabetes drug metformin can prevent blood sugar increases caused by statins in people with schizophrenia. Researchers will give 400 patients either metformin or a placebo alongside atorvastatin for six months. The goal is to see if metformin helps kee…

This study tests a personalized approach to brain stimulation for people with major depression that hasn't improved with standard treatments. A device implanted in the brain measures each person's unique depression-related brain activity and delivers small electrical impulses to …

This study tests whether esketamine nasal spray, used by itself, can reduce depression symptoms in adults whose depression has not improved with at least two prior antidepressant treatments. Participants are randomly assigned to receive either a low dose (56 mg), a high dose (84 …

This trial tests whether machine learning can help choose the most effective digital mental health program for each person with anxiety or depression. About 1,800 adults will be randomly assigned to one of three online therapy programs, and the study will use the results to build…

This study compares two weight-loss strategies: GLP-1 medications (like semaglutide or tirzepatide) versus a structured diet and exercise program. Adults with a BMI of 27.5 or higher are followed for three months to see which approach better improves heart and metabolic markers, …

This study tests whether the drug lumateperone can safely reduce symptoms of depression in children and teenagers (ages 10 to 17) with bipolar I or II disorder who are currently in a major depressive episode. Participants receive either lumateperone or a placebo daily for several…

This trial investigates whether a next-generation deep brain stimulation (DBS) system can reduce symptoms in people with major depression that hasn't improved with standard treatments. The device uses directional current steering to precisely target brain networks thought to be i…

This trial tests whether an artificial intelligence tool called StratCare can improve depression treatment by recommending personalized therapy paths. About 1,250 adults with depression will be split into two groups: one using StratCare to guide treatment choice, the other follow…

This phase 2 trial tests whether semaglutide, a GLP-1 drug used for diabetes and weight loss, can help adults with opioid use disorder avoid using illicit opioids. Participants already receiving buprenorphine or methadone treatment will take weekly semaglutide or a placebo for 12…

This trial tests whether a wearable headband called ATTN201 can safely reduce obsessive-compulsive disorder (OCD) symptoms. The device delivers low-intensity focused ultrasound to a deep brain region involved in OCD, without surgery. Forty adults with moderate-to-severe OCD will …

This phase 3 trial tests whether an experimental drug called MI078 can safely reduce symptoms of postpartum depression in new mothers. About 200 women aged 18 to 45 with a recent diagnosis of major depression linked to childbirth will receive either MI078 capsules or a placebo fo…

This study examines whether therapist-guided internet-based cognitive behavioral therapy (ICBT) works well and saves money when used in routine healthcare for moderate depression, social anxiety disorder, and panic disorder. About 800 adults with these conditions will receive up …

This phase 3 trial tests whether solriamfetol, taken once daily, can reduce ADHD symptoms in children aged 6 to under 12. Over 6 weeks, researchers compare the drug against a placebo using a standard rating scale. The goal is to see if solriamfetol is a safe and effective treatme…

This study tests whether solriamfetol, a medication taken once daily, can reduce symptoms of attention deficit hyperactivity disorder (ADHD) in adolescents aged 12 to 18. Over six weeks, participants receive either solriamfetol or a placebo to compare changes in ADHD symptoms. Th…

This phase 2 trial tests whether ublituximab, an immune-modulating drug, can reduce symptoms in people with treatment-resistant schizophrenia. Participants receive the drug by IV infusion, and researchers measure changes in symptom scores over time. The goal is to see if targetin…

This pilot study tests a 10-session program called the Cognitive Orientation to Daily Occupational Performance (CO-OP) approach in primary school-aged children with autism. The program teaches children to use cognitive strategies like 'Goal-Plan-Do-Check' to improve performance o…

This trial investigates an unapproved medical device designed to help control a specific disease. Participants receive the device to see if it can reduce symptoms or manage the condition. The study focuses on safety and effectiveness in people with the disease.

This study tests whether a 6-week digital mindfulness program, delivered through a mobile app, can help people with obsessive-compulsive disorder (OCD) manage their symptoms. The trial compares the digital therapy alone, standard medication alone, and a combination of both in 150…

This study tests whether adding a specific blend of two probiotics (Lactobacillus helveticus and Bifidobacterium longum) to standard antidepressant medication helps reduce depression symptoms more than antidepressants alone. Adults aged 18 to 60 with major depressive disorder who…

This study tests a Transition Care Team (TCT) designed to help people with first episode psychosis successfully move from hospital to outpatient mental health services. The TCT provides short-term support including therapy, case management, and coordination with community program…

This study tests a web-based program called Web-SUCCEED that helps veterans with chronic illness and their informal caregivers work together to manage the condition. The program includes three weekly online modules and brief phone calls with staff, focusing on stress coping and c…

This study tests whether a single 45-minute psychiatric interview, given soon after ICU discharge for sepsis, can lower the risk of developing post-traumatic stress disorder (PTSD). Many ICU survivors face long-term mental health issues, but most hospitals lack early screening an…

This study tests a parent-led, home-based play program designed to improve social cognitive skills—like recognizing emotions and understanding others' perspectives—in young children with autism. Parents are trained to deliver daily 30-minute cooperative games for six months, with…

This trial tests whether a structured physical exercise program can improve memory, attention, and other thinking skills in adults with bipolar disorder who already have some cognitive difficulties. Participants will be randomly assigned to exercise or usual care, and researchers…

This study tests whether playing action video games can improve reading in children with dyslexia by training their visual attention. About 76 Cantonese-speaking children with dyslexia will be randomly assigned to play either an action game or a non-action game for 12 hours. Rese…

This study tests whether combining a leadership alignment program with a champion strategy helps clinics in Malawi better integrate mental health care for anxiety and depression. About 1,080 adult patients who screen positive for these conditions will take part. The goal is to se…

This Phase 3 trial investigates whether a psychedelic drug, psilocybin, combined with a specialized trauma-focused therapy (SIRT), can improve depression and anxiety in people with trauma-related major depressive disorder. The study also looks at changes in gut-brain axis biomark…

This study tests whether a multi-strain probiotic called Visbiome can change brain activity and gut bacteria in people aged 15 to 24 with depression. Participants take either the probiotic or a placebo powder daily for several weeks. Researchers use brain scans and stool samples …

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in people with schizophrenia. Thirty participants receive both real and sham stimulation in separate sessions while pe…

This study tests whether adding a motivation-enhancing module and a shared decision-making session before standard PTSD treatment can reduce dropout and improve outcomes. Adults with PTSD at two clinics are randomly assigned to receive standard care, the motivation module plus st…

This study tests a program to help new mothers with chronic conditions like high blood pressure, diabetes, or depression transition smoothly from obstetric to primary care after giving birth. The program includes automatically scheduling a primary care visit, sending personalized…

This study tests whether adding a four-week aerobic exercise program to a new antipsychotic medication (olanzapine-samidorphan) can prevent the early weight gain often seen with these drugs. Thirty adults with schizophrenia, schizoaffective disorder, or bipolar disorder will take…

This trial investigates whether a non-invasive brain stimulation technique called tACS, applied during speech therapy, can help people recover language abilities after a stroke. The study includes 120 adults who have had a left-hemisphere stroke and experience aphasia (difficulty…

This study tests whether personalized nutrition counseling can lower inflammation in adults with schizophrenia who are on long-term antipsychotic medication. Participants receive either a tailored diet plan or standard hospital meals. The goal is to see if better nutrition can re…

This study tests whether cognitive behavioral therapy (CBT) for parents of very premature infants in the NICU can reduce feelings of child vulnerability and improve the child's development. Parents in the intervention group receive five CBT sessions during and after the NICU stay…

This study tests whether giving choline supplements to pregnant women who drink heavily can reduce the negative effects of alcohol on their baby's growth and brain development. Choline is an essential nutrient that supports cell membranes and brain function. The trial compares da…

This study tests whether people with major depression can learn to boost activity in a key motivation area of the brain (the ventral tegmental area) using real-time feedback from a powerful 7-Tesla MRI scanner. Participants will practice this mental technique over multiple sessio…

This study tests whether a group-based parenting program called the Chicago Parent Program can improve executive function—skills like self-control and focus—in 4- and 5-year-olds from low-income families. Children and their parents will be randomly assigned to the program or a co…

This study explores whether MDMA (ecstasy) combined with talk therapy can help Israeli special forces veterans suffering from PTSD and moral injury. Participants receive a flexible dose of MDMA in either individual or group therapy sessions. The goal is to measure changes in PTSD…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve the brain's wiring and connectivity in people with schizophrenia. Participants receive multiple sessions of rTMS using a special coil designe…

This study tests whether combining a non-invasive brain stimulation technique called rTMS with computer-based cognitive training can strengthen brain connections in people with schizophrenia. Participants will receive up to 10 sessions over two weeks, and researchers will use bra…

This study tests whether a short-term, intensive form of PTSD therapy can quickly reduce symptoms and improve thinking skills in military personnel. Participants receive either Cognitive Processing Therapy (CPT) or Eye Movement Desensitization and Reprocessing (EMDR) over a conde…

This study tests whether adding team-building tools—like team charters, communication handoffs, and performance monitoring—to an existing school-based ADHD program (the Collaborative Life Skills Program) makes it work better. Researchers will compare the enhanced program to the s…

This study tests a mobile health app called uMAT-R, designed to help Black adults recover from opioid or stimulant use and manage depression or anxiety. Participants are recruited from community treatment centers and use the app to track substance use and mental health symptoms. …

This study tests whether starting virtual reality-based rehabilitation within 24 hours of an acute ischemic stroke can improve arm muscle strength, thinking skills, and motivation to exercise. One hundred adults recently diagnosed with stroke will be randomly assigned to either v…

This study is testing whether a cochlear implant is safe and effective for infants and toddlers who are deaf in one ear. Sixty children will receive the implant and be followed until age 5. Researchers will compare their hearing abilities to children with normal hearing and to th…

This phase 2 study tests whether the sleep medication suvorexant can reduce insomnia in 76 adults aged 21–65 who have both alcohol use disorder and posttraumatic stress disorder. Participants take either suvorexant or a placebo for 14 days while trying to stop drinking. The study…

This study investigates whether ketamine, given as four intravenous infusions over two weeks, can reduce depression and alcohol cravings in adults who have both conditions. Participants are already in inpatient addiction therapy and are randomly assigned to receive either ketamin…

This pilot study explores whether computer-assisted music remediation can improve memory, attention, and thinking in young people aged 18 to 30 who have had a first psychotic episode. Participants attend weekly group sessions using music software to practice memory and executive …

This study tests a therapy toolkit called Signs of Safety, designed for Deaf individuals who use American Sign Language and struggle with alcohol use disorder and PTSD. The toolkit adapts an existing therapy (Seeking Safety) to be Deaf-accessible. Researchers compare it to treatm…

This study tests whether adding sodium benzoate—a substance that affects brain glutamate—to standard antipsychotic medication can improve symptoms and thinking in people with treatment-resistant schizophrenia. About 90 adults who have not responded well to at least two antipsycho…

This study tests a radioactive tracer called 18F-AIPF-1026 that binds to monoamine oxidase A (MAO-A), an enzyme linked to depression, anxiety, and heart injury. About 200 adults with these conditions will receive a single injection of the tracer and then undergo PET/CT or MRI sca…

This study tests whether an online parenting program, eHealth Familias Unidas, can reduce symptoms of depression, anxiety, and suicidal behavior in Hispanic adolescents aged 12 to 16. The program involves 13 online sessions that aim to strengthen family communication and protecti…

This study tests a simple talking therapy for heart surgery patients while they are still in the ICU. The therapy uses a visitor book with photos and family messages to help patients process stressful memories. Researchers hope this can prevent posttraumatic stress disorder (PTSD…

This pilot study will test a 10-session virtual group program called Parents and Babies, designed to prevent postpartum depression in LGBTQ+ parents. The program teaches coping skills based on cognitive-behavioral therapy. Researchers will enroll 16 LGBTQ+ individuals who are pre…

This trial tests whether a self-guided mindfulness app can help reduce pain after a cesarean delivery and prevent postpartum depression. The study enrolls women aged 18-45 who are scheduled for a planned C-section, have a history of depression, and show mild depressive symptoms. …

This study tests a digital tool called the Family Check-Up Online, designed to prevent family violence and improve child mental health. About 1,270 families with children aged 11-14 will use the program, with some getting extra coach support. Researchers will measure changes in p…

This study investigates whether taking vitamin B6 supplements during late pregnancy and after childbirth can help prevent depression. Pregnant women without a history of mental health conditions take either vitamin B6 or a placebo from around 24-28 weeks of pregnancy until six we…

This study explores whether visiting a museum can support the social and emotional well-being of autistic adults. Researchers plan to enroll 90 autistic adults aged 18 to 50 with average intellectual ability. Participants choose one of three options: a solo museum visit, five gui…

This pilot study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) in 20 adults with a history of childhood trauma and current suicidal thoughts. The therapy combines coping skills training with trauma-focused treatment to address both suicide risk and t…

This Phase 2 trial will test whether adding selenium supplements to standard antidepressant medication (fluoxetine) can improve depression symptoms in 172 children and adolescents aged 12-18 with major depressive disorder. Participants will receive either selenium or a placebo fo…

This study tests a program called Grow with Grit, where school nurses screen children aged 8-12 in rural Montana for anxiety using a standard questionnaire. Children who show signs of anxiety receive a brief, 3-5 minute coping-skills session during a regular nurse visit, along wi…

This Phase 3 study tests whether CYB003, a psilocin analog (related to the active ingredient in magic mushrooms), can safely reduce depression symptoms in 330 adults with major depressive disorder. Participants receive either one of two doses of CYB003 or a placebo, along with ps…

This study tests whether a strict high-fat, low-carbohydrate (ketogenic) diet can help ease depression in people with bipolar disorder. Thirty adults aged 18 to 50 with bipolar I or II will follow the diet for 8 weeks while researchers track mood changes and heart health. The goa…

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce psychiatric symptoms in people with early bipolar disorder. Fifty participants will follow either the ketogenic diet or standard dietary guidelines for 12 weeks. Researchers will me…

This study tests a new drug called SPT-300 in 360 adults with major depressive disorder, with or without anxiety. Participants will receive either the drug or a placebo for 6 weeks to see if it reduces depression symptoms. The goal is to find a safe and effective new treatment op…

This Phase 3 trial tests whether fenfluramine (Fintepla) can reduce behavioral and emotional symptoms in people with Rett syndrome. About 200 participants will receive either the drug or a placebo for 14 weeks. The study measures changes in behavior, sleep, and overall condition …

This study tests an experimental drug called ITI-1284 for people with generalized anxiety disorder (GAD) whose current treatment isn't working well enough. About 705 adults will receive either ITI-1284 or a placebo added to their usual therapy. The goal is to see if the drug safe…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. About 48 participants will receive hypnosis sessions alongside standard care, while researchers monitor brain activity with …

This pilot study will test whether a mobile phone app can help reduce depression symptoms in African American adults. Eight participants will attend six weekly 90-minute classes through the app and complete surveys over four months. The goal is to see if this approach is effectiv…

This trial tests whether daily music training—either piano practice or listening to music—can improve behavior and thinking in children with fetal alcohol spectrum disorder (FASD). Each child will do both activities for 12 weeks each, in a random order, with tests before and afte…

This trial tests two ways to bring nature to older adults stuck in the hospital for weeks: watching 360-degree nature videos through a virtual reality headset, or listening to audio guides that prompt them to imagine the same scenes. Both approaches use identical nature themes—me…

This trial explores whether wearing a bright light device for 60 minutes each morning for five weeks can help new mothers with postpartum depression. It focuses on whether the treatment is practical and acceptable to participants, and how it might be implemented in real-world set…

This study tests an experimental drug called icalcaprant for treating depression in people with bipolar I or II disorder. About 195 adults will take either the drug or a placebo daily for 6 weeks. Researchers will measure changes in depression symptoms and watch for side effects.

This study tests if a noninvasive, at-home brain stimulation device (tDCS) can safely ease symptoms of major depression. Two hundred adults with depression will use the device themselves at home for 10 weeks, with video check-ins. The goal is to see if this approach reduces depre…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help veterans with depression that hasn't improved with at least two other treatments. 240 veterans will receive either psilocybin or a placebo in a controlled setting. The goal is to see if it red…

This trial tests whether using a weighted blanket at night and during the day can improve sleep in children aged 5-12 with ADHD who still have sleep problems despite standard care. Half the children will receive a weighted blanket, while the other half gets a non-weighted sham bl…

This pilot study tests a bedtime routine called 'The Power Down' for autistic children aged 6 to 10 who have trouble settling down to sleep. The routine uses gentle massage and calming sounds to help children relax before bed. Caregivers will lead the routine each night for two w…

This study tests a computer-based therapy for adults with social anxiety disorder. Researchers want to see if it reduces anxiety and improves quality of life. About 80 people aged 18 to 60 with social anxiety will participate. The therapy is designed to be a new, accessible treat…

This study looks at whether a store-bought weighted blanket can help children aged 5-12 with ADHD who have trouble sleeping. 100 kids will use the blanket every night for 4 weeks, and researchers will track their sleep with a wrist monitor. The goal is to see if the blanket incre…

This trial tests a structured, 8-session program designed to help adults who stutter feel less anxious and more confident in job interviews. The program uses techniques like cognitive restructuring, voluntary stuttering, and simulated interviews to gradually reduce fear of negati…

This study tests a new form of transcranial magnetic stimulation (TMS) for post-traumatic stress disorder (PTSD). Unlike standard TMS, which takes 6-7 weeks, this accelerated version delivers 10 sessions per day for 5 days. Researchers will enroll 40 adults with PTSD to see if ac…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help reduce depression, anxiety, and stress in adults whose parents survived genocide. One hundred participants will receive a single 25mg dose under supervision, followed by …

This study investigates whether a single dose of psilocybin, the active compound in magic mushrooms, can reduce rumination—repetitive negative self-focused thinking—in people with major depressive disorder. Researchers will use brain scans to see how psilocybin changes activity i…

This large study tests a collaborative care model (COMPASS+) that adds a mental health care manager to regular obstetric care for pregnant and postpartum people. The care manager offers short-term therapy, tracks symptoms, and works with doctors and a psychiatrist to create perso…

This study looks at whether teaching people with a colostomy or ileostomy how to care for their stoma helps them adjust better, feel better about their body, and manage their daily life. About 100 adults who had planned stoma surgery will take part. The goal is to see if educatio…

This trial tests whether a structured talk therapy called ConquerFear can help people with advanced cancer manage their fear of the disease progressing. It compares ConquerFear to a supportive-expressive approach, which focuses on emotional expression and support. The study invol…

This study tests whether adding a computer task called gaze-contingent music reward therapy (GCMRT) to standard cognitive behavioral therapy (CBT) helps reduce anxiety in children aged 8 to 17. In GCMRT, children look at faces on a screen while pleasant music plays or stops depen…

This study looks at whether a simple, non-needle ear acupressure technique can lower anxiety and pain in women having breast surgery after a first breast cancer diagnosis. About 66 women will either get standard care or standard care plus ear acupressure. The goal is to see if th…

This study tests whether a structured nursing program—including patient education, emotional support, and clear communication—can help men feel more resilient and less anxious when undergoing a transrectal prostate biopsy. Around 120 men scheduled for the procedure will receive t…

This study tests whether low-intensity focused ultrasound (LIFU), a gentle sound wave technique, can safely improve speech fluency in people who stutter. Twenty adults who stutter will receive LIFU or a sham treatment, and researchers will measure changes in stuttering severity a…

This study tests Mom-Net, an online cognitive behavioral therapy program with coaching, for low-income mothers with depression whose children are in Head Start. About 960 mothers will be assigned to Mom-Net or usual care, with coaching provided by Head Start staff. The goal is to…

This phase 2 trial at MD Anderson Cancer Center is testing whether psilocybin-assisted psychotherapy can safely help ease depression and anxiety in 30 adults with advanced cancer who are on maintenance therapy. Participants receive either psilocybin or a placebo (niacin) along wi…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain involvement will receive a single dose of psil…

This study tests a new drug called RR-HNK (related to ketamine) to see if it safely reduces obsessive-compulsive disorder (OCD) symptoms. About 45 adults with OCD who haven't improved with standard treatments will receive two doses of the drug or a placebo. The main goal is to me…

This phase 2 trial is investigating whether two doses of psilocybin (25 mg each, given 4 weeks apart) combined with psychotherapy are safe and acceptable for people with bipolar II disorder who are experiencing depression and suicidal thoughts. The study enrolls 10 adults aged 25…

This trial investigates whether a low-dose psilocybin oral solution can safely ease symptoms of generalized anxiety disorder (GAD). Adults aged 18-60 with a GAD diagnosis and moderate-to-severe anxiety will first receive open-label psilocybin for four weeks, then those who respon…

This phase 2 trial tests whether DT-101 can ease depression symptoms in adults with major depressive disorder who are already on antidepressant medication. About 118 participants will receive either DT-101 or a placebo, and researchers will track changes in depression scores over…

This trial explores whether a non-invasive device that delivers mild electrical stimulation to the head can help reduce anxiety before meals in adults hospitalized for eating disorders. Participants will use the Alpha-Stim AID device for 20-minute sessions before breakfast, lunch…

This study tests a quick, non-invasive brain stimulation method called accelerated intermittent theta-burst stimulation (aiTBS) to see if it can improve mood in people with borderline personality disorder (BPD) who are also experiencing a major depressive episode. About 45 adults…

This early-stage trial tests BXCL501, a dissolving film placed under the tongue, to quickly reduce agitation in children and teens aged 10-17 with schizophrenia or bipolar disorder. About 140 participants will receive either the drug or a placebo. The study measures changes in ag…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve symptoms of major depression and chronic pain at the same time. Fifty-four adults with moderate depression and pain will receive 30 sessions of active rTMS over several weeks. Researchers …

This study tests whether combining virtual reality therapy with a mild brain stimulation technique can help veterans and civilians in Ukraine cope with PTSD. Participants attend 10 therapy sessions using VR goggles to safely face traumatic memories, with some also receiving a gen…

This trial tests an experimental drug called LTX-001 in adults with schizophrenia who are experiencing a sudden worsening of symptoms. Participants stay in a research unit for about five weeks and receive either LTX-001 or a placebo. The main goal is to see if the drug is safe an…

This trial tests whether watching cartoons or squeezing a stress ball can reduce fear, anxiety, and pain in children aged 4-10 during allergy skin testing. Ninety children will be randomly assigned to one of three groups: cartoon-watching, stress ball use, or routine care. Resear…

This study tests whether a single dose of the drug Epidiolex (cannabidiol, or CBD) can reduce feelings of anxiety, physical stress signs, and brain activity linked to anxiety in people with social anxiety disorder. About 50 adults aged 18-55 with significant social anxiety will t…

This Phase 3 trial tests whether adding NBI-1065845 to standard antidepressants can better ease depression symptoms in 200 adults who haven't fully responded to current treatments. Participants take the drug or a placebo for 8 weeks, and doctors measure changes in mood and daily …

This study tests whether a noninvasive brain stimulation technique called iTBS can improve working memory in people with early-stage schizophrenia. Researchers will use magnetic pulses and EEG to measure brain activity before and after stimulation. The goal is to see if iTBS can …

This study tests SloMo, a digital therapy that helps people with psychosis who fear harm from others. It combines face-to-face sessions with a mobile app to help users notice worries and slow down fast thinking. 150 participants across three NHS trusts will try the therapy, with …

This study tests whether a specialized speech therapy that focuses on word meanings can help people with mild-to-moderate semantic aphasia—a condition where brain damage impairs understanding and use of words. Participants first undergo a control period of standard language exerc…

This trial tests whether a non-invasive brain-stimulation device called transcranial direct current stimulation (tDCS) can reduce symptoms of moderate-to-severe depression in pregnant people. Participants use the device at home for 15 sessions over three weeks, while a comparison…

This trial tests whether an ultrasound-guided nerve block, using the anesthetic bupivacaine, can reduce pain and the need for opioid painkillers after laparoscopic gallbladder removal. Sixty adults with a healthy weight and low surgical risk will receive either the nerve block or…

This phase 3 study is testing an oral drug called DT120 (related to LSD) against a placebo in 165 adults with major depressive disorder. Participants will take the drug or placebo for 12 weeks, followed by a 40-week period where everyone can receive DT120. The main goal is to see…

This trial tests whether a smartphone app called AffectUs can help people with schizophrenia or schizoaffective disorder better recognize emotions and interpret social situations. Participants use the app for 10 weeks, five times a week, while continuing their usual treatment. Th…

This trial tests whether Deprexis, a self-guided online program, can reduce depressive symptoms and improve daily functioning in veterans with mild to moderate depression. Participants will use the 12-module program over 8 weeks, and their progress will be compared to those recei…

This study tests a single injection of apimostinel, a fast-acting antidepressant, in 150 adults with major depression. Half also receive digital cognitive training sessions to see if it extends the drug's effects. The trial is placebo-controlled and double-blind, meaning neither …

This study tests an online wellness course that teaches diet, exercise, stress reduction, and self-care to people with rheumatoid arthritis, lupus, Sjogren's syndrome, and similar conditions. Researchers want to see if the program reduces fatigue and improves quality of life. Abo…

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This study tests whether AI-powered modules, accessed through a phone or computer app, can help autistic individuals improve social communication. Participants practice skills like empathy, asking questions, and listening, receiving feedback via voice recognition. The goal is to …

This study tests a wearable device worn on the ear that stimulates nearby nerves to change brain signals. The goal is to see if it can reduce chronic pain and ease symptoms of opioid withdrawal. Adults aged 18 to 65 with chronic pain who are tapering off opioid medication will re…

This Phase 3 trial is testing whether an experimental drug called NBI-1065845 can help reduce depression symptoms in adults who haven't responded well to standard antidepressants. About 200 participants will take either the drug or a placebo alongside their current antidepressant…

This study tests whether a single dose of psilocybin, given with psychological support, can improve depression in people with Parkinson's disease. Sixty adults aged 40 to 80 with mild to moderate Parkinson's and depressive symptoms will receive either a low or high dose of psiloc…

This study tests whether a virtual reality program can help children with ADHD improve their attention by repeatedly exposing them to distractions in a simulated classroom. The idea is that, like getting used to a loud noise, children may become less reactive to distracting sight…

This study tests a new anonymous online therapy program called Restory for people with PTSD after sexual abuse. It is designed for 140 adults who have experienced sexual violence at least one month ago. The therapy uses a type of talk therapy done over the internet, and the goal …

This study tests a program called Parenting STAIR Modular (PSTAIR-M) for military-connected mothers who have experienced trauma and have young children aged 2-10. The program helps mothers manage PTSD and depression symptoms while improving their parenting skills. Researchers wil…

This trial tests whether listening to music before, during, and after surgery can lower anxiety, reduce pain, and cut down on painkiller use. About 410 healthy adults having day surgery, gynecologic surgery, or cesarean section will be involved. Participants in the music group wi…

This study looks at whether cannabis can help veterans who have PTSD and thoughts of suicide. About 500 veterans who have used cannabis in the past year will take part. Researchers will track changes in PTSD symptoms, mood, and suicide risk over time using interviews and question…

This study tests a short, three-session online program designed to help caregivers of people with advanced prostate cancer manage their fear that the cancer will progress. The program teaches techniques like detached mindfulness to help caregivers relate to worrying thoughts in a…

This study tests whether a new form of exposure therapy, called Expectancy Focused Exposure (EFE), can reduce anxiety symptoms and prevent fear from returning more effectively than traditional exposure therapy. Adults with anxiety disorders—such as social anxiety, panic disorder,…

This study looks at whether adding hypnosis or relaxation sessions to standard psychological care can lower anxiety in children, teens, and young adults who have finished treatment for pediatric cancer. About 558 participants aged 7 to 25 who are in remission and have anxiety wil…

This study tests whether a computer-based working memory training program can help veterans with PTSD improve their ability to unlearn fear responses. 120 veterans will be randomly assigned to either the training or a sham version. The goal is to see if the training changes brain…

This study tests whether a smartphone app called Bodhi AIM can help youth aged 13–20 who are on probation or in related legal programs improve their psychological wellbeing and reduce distress. Participants use the app for one month, following daily guided meditations. The trial …

This study tests a brief group therapy called Acceptance and Commitment Therapy for insomnia (ACT-i) in 76 adults aged 18-59 with chronic insomnia and mild depression or anxiety. Participants are randomly assigned to either ACT-i or a general support group. The goal is to see if …

This study tests a new medicine called ACP-211 in adults with major depression who haven't gotten better with standard antidepressants. About 153 people will receive either the drug or a placebo for 28 days. The main goal is to see if ACP-211 reduces depression symptoms more than…

This trial tests a technology-based program called the Parenting Young Children Check-up (PYCC) for parents of children aged 2 to 5 with challenging behavior. Fifty parents from a Detroit pediatric clinic serving low-income families will be randomly assigned to either the program…

This study tests a smartphone app called CALM that teaches veterans with traumatic brain injury and PTSD strategies to improve focus, planning, and self-control. One hundred veterans and a family member or friend will be randomly assigned to use the app or receive brain health ed…

This study tests whether lumateperone (Caplyta) can help older adults (60+) whose depression hasn't improved with other treatments. One hundred participants will take either the drug or a placebo alongside their current antidepressant for 10 weeks. Researchers will measure change…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study will test if an internet-based cognitive behavioral therapy (iCBT) program can help reduce symptoms of mild-to-moderate anxiety and depression in adults in Singapore. About 390 participants will either receive the 8-week online program with counselor check-ins or conti…

This study tests whether a brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help ease depression in people with schizophrenia. Researchers will give up to 20 sessions of active or sham rTMS to 120 participants and use brain scans to see h…

This study tests a group-based program called GEARS that teaches emotion regulation skills to adults with ADHD. Researchers will compare 150 participants who receive GEARS to those on a waiting list, measuring changes in emotional control, ADHD symptoms, and quality of life. The …

This study tests whether a nerve block (injecting numbing medicine near a nerve in the ear) can reduce pain and the need for strong painkillers after middle ear surgery. About 56 adults having ear surgery will be randomly assigned to get the nerve block or standard care. The main…

This pilot study tests whether repeated transcranial magnetic stimulation (rTMS) can reduce stuttering in adults. Two participants will receive 10 rTMS sessions, and researchers will measure changes in brain activity and speech. The goal is to see if this non-invasive treatment c…

This study tests whether a daily medication called vortioxetine can safely reduce depression symptoms in Japanese teenagers aged 12 to 17 with major depressive disorder. About 180 participants will receive either the drug or a placebo for 14 weeks, with follow-up for 4 more weeks…

This study tests an AI companion called Baba that calls or texts older adults who live alone. Baba uses conversational AI to chat, track emotions, and alert caregivers if needed. The goal is to see if regular conversations can reduce loneliness and improve mood over 12 weeks.

This study investigates whether adding the steroid dexamethasone to a standard ultrasound-guided nerve block (transversalis fascia plane block) can improve pain control after cesarean delivery. Researchers will compare opioid use, pain scores, and recovery quality in women who re…

This study tests whether a generative AI chatbot can help new mothers learn about pelvic floor health and reduce feelings of loneliness after childbirth. Researchers will compare standard postpartum care with or without access to the chatbot over 4 weeks. The trial involves 130 f…

This study tests two digital mindfulness programs—one live over Zoom and one self-paced app—to see if they can reduce depression in younger breast cancer survivors. It includes 402 women diagnosed at or before age 50 who finished cancer treatment at least 6 months ago and have el…

This study compares using virtual reality glasses versus the standard 'show-do' technique to reduce dental anxiety in 54 children with moderate to severe hearing impairment. The children will have their pulse and anxiety scores measured during a dental cleaning. The goal is to se…

This study is testing a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help adults who have had a stroke manage anxiety and depression. About 10 participants aged 40-79 will use the app and provide feedback on how easy and helpful it is. The goal is to…

This trial tests whether aromatherapy with rose oil or a massage using that oil can reduce pain, anxiety, and discomfort in women after a cesarean delivery. About 90 first-time mothers will be randomly assigned to receive one of these treatments or a placebo. The goal is to see i…

This study tests whether a type of talk therapy called behavioral activation, delivered over telehealth, can reduce depression and suicidal thoughts in teens aged 12-17. Participants will attend weekly virtual sessions for 8-10 weeks, learning to engage in enjoyable and meaningfu…

This study tests whether a new medication called azetukalner can reduce depression symptoms in adults with moderate-to-severe major depressive disorder. About 450 participants will receive either the drug or a placebo for 6 weeks. The main goal is to see if the drug improves mood…

This study tests whether a new oral drug called zelquistinel can reduce depression symptoms in adults with major depressive disorder. Participants take one tablet weekly for 6 weeks and have their depression severity checked at each clinic visit. The trial compares the drug again…

This study tests whether a type of magnetic brain stimulation called iTBS can help people with PTSD. Researchers will give 140 adults either real or fake (sham) stimulation to see if it reduces symptoms like flashbacks and anxiety. The goal is to find a new, non-drug treatment op…

This trial tests a peer-led program called Honest, Open, Proud (HOP) for veterans with mental health or substance use disorders who have been involved with the justice system. The program helps participants decide whether, when, and how to disclose their conditions, with the goal…

This study tests an experimental drug called azetukalner in 450 adults with moderate-to-severe major depression. Participants take the drug or a placebo daily for 6 weeks to see if it reduces depression symptoms like low mood and loss of pleasure. The goal is to find a new treatm…

This study tests whether using a mobile app called the Safe and Sound Protocol (SSP) can help adults who are in treatment for substance use and have a history of trauma. About 100 participants will either use the active SSP or a sham version for up to 5 hours over a week, alongsi…

This small study will test whether giving a 15-20 minute massage during infusion therapy can reduce pain and anxiety in women with gynecologic cancer. Twenty-four participants will be randomly assigned to receive either a hand, foot, or neck/shoulder massage or simply talk with t…

This study tests whether the drug lumateperone can safely reduce irritability in children aged 5 to 17 with autism spectrum disorder. Participants receive either a high or low dose of lumateperone or a placebo daily. The main goal is to see if the drug improves irritability score…

This study tests whether a 16-week social skills program, called PEERS, can improve social functioning in adults with autism spectrum disorder (ASD). Researchers will measure changes in social symptoms and brain activity related to social processing. The goal is to see if this be…

This study tests whether theatrical improvisation can help children and adolescents aged 8 to 17 who have elevated anxiety or depression. Participants are randomly assigned to one of three groups: improv combined with wellness techniques (like cognitive-behavioral skills), improv…

This trial tests a structured, parent-assisted social skills program called PEERS® for adolescents with autism spectrum disorder. The program uses cognitive-behavioral techniques to teach practical skills for making and maintaining friendships. Researchers will measure changes in…

This study tests whether adding lumateperone to standard antidepressant therapy can better relieve depression symptoms in adults aged 18 to 65 with major depressive disorder. Participants receive either lumateperone or a placebo daily for several weeks, and researchers measure ch…

This study tests a couple group therapy program designed for adults with autism spectrum disorder (ASD) and their partners. The program teaches communication skills like using "I" statements, focusing on conversations, and giving positive feedback. The goal is to improve relation…

This trial tests whether watching cartoons or having a parent present during dental treatment better reduces anxiety in children aged 4 to 11. Researchers will measure heart rate and oxygen levels to see which approach is more calming. The goal is to find simple, non-drug ways to…

This trial tests whether a structured social skills program, called PEERS, can help adults with autism improve their social interactions and relationships. Participants aged 18 to 45 with relational difficulties and a caregiver's support will either join the program or be in a co…

This study tests a smartwatch-based program designed to help people with post-stroke aphasia—a condition that impairs language—improve their ability to name objects. Over six weeks, participants receive daily prompts to name pictures and answer simple yes/no questions about the i…

This study tests whether the drug lumateperone can safely reduce irritability in children aged 5 to 17 who have autism spectrum disorder. Participants receive either a high dose, low dose, or placebo daily for several weeks. Researchers measure changes in irritability using a sta…

This trial tests whether a structured education session for family members of ICU patients about to receive a tracheostomy can lower their anxiety, boost their psychological well-being, and increase their satisfaction with care. Half of the participants get the structured program…

This trial tests whether listening to binaural beats — a type of sound that may gently nudge brain waves — can improve cognitive function in older adults with mild cognitive impairment living in nursing homes. Participants listen to old songs with or without embedded binaural bea…

This early-stage pilot study is testing whether psilocybin, a psychedelic compound, can be safely combined with trauma-focused psychotherapy for people with post-traumatic stress disorder (PTSD). Thirteen participants will receive two doses of psilocybin in a controlled setting, …

Endometriosis often causes long-lasting pelvic pain that can disrupt daily life. This trial tests whether specialized pelvic floor physical therapy, combined with a structured exercise program, can lower pain more than a placebo version of the therapy. Women aged 18 to 45 with co…

This phase 2 trial is testing whether the drug lumateperone can reduce stuttering symptoms in adults with moderate to severe childhood-onset stuttering. Participants take either lumateperone (21 mg or 42 mg) or a placebo daily for several weeks. Researchers will measure changes i…

This trial tests a technology-based program called the Parenting Young Children Check-up (PYCC) for parents of children ages 2 to 5 with challenging behaviors. The program includes an initial check-up, text messages, and a website. Researchers will compare families who receive th…

This trial tests whether an 8-week mindful self-compassion training can reduce symptoms of anxiety and depression in adults diagnosed with generalized anxiety disorder, social anxiety disorder, panic disorder, or major depressive disorder. Participants are randomly assigned to th…

This trial tests whether a video-delivered therapy called Tele-PROTECT can reduce depression and increase feelings of safety and empowerment in older adults who have experienced elder abuse. Around 140 English- and Spanish-speaking participants aged 60 and older will receive eith…

This trial tests whether a new online group therapy called Natural Psychotherapy (NPT) can reduce anxiety symptoms in Chinese university students. NPT encourages participants to actively seek out and engage with life's challenges as a way to grow, rather than avoid discomfort. Re…

This study follows veterans who completed 40 sessions of hyperbaric oxygen therapy (HBOT) for traumatic brain injury, post-concussive symptoms, or PTSD. Researchers want to see if improvements in thinking, mood, and daily function persist or even grow after treatment stops. Parti…

This study tests whether an 8-week mindfulness program can reduce anxiety and depression in adults with mild emotional distress. Participants are randomly assigned to either mindfulness training or progressive muscle relaxation. Researchers use brain scans to see if mindfulness c…

This trial tests whether a therapy that blends Exposure and Response Prevention (ERP) with Habit Reversal Training (HbRT) can reduce both obsessive-compulsive and tic symptoms in adults with Tourettic OCD — a subtype where OCD and tic disorders overlap. Standard treatments usuall…

This study tests a program called Confident Caregiver, designed to help family members who care for someone with heart disease. Caregivers receive four personalized coaching sessions focused on managing challenges, reducing stress, and connecting with support resources. The goal …

This trial compares a novel behavioral treatment called ABC-I (Acceptance and the Behavioral Changes to treat Insomnia) with standard cognitive-behavioral therapy for insomnia (CBT-I) in veterans who have both PTSD and insomnia. ABC-I combines sleep-focused behavioral techniques …

This trial tests whether sertraline, a widely used antidepressant, can reduce anxiety in children and teens aged 8 to 17 with neurodevelopmental disorders such as autism, ADHD, Fragile X syndrome, and Tourette syndrome. Participants receive either sertraline or a placebo for seve…

This clinical trial tests whether a 15-week parent-led nutrition program called Exploradores de Sabores can help children aged 4 to 11 with autism spectrum disorder eat a more varied diet and improve their nutritional status. Caregivers attend weekly group sessions with a dietiti…

This trial tests whether a six-week online group program, combining cognitive behavioural therapy with family support, can help people with schizophrenia and their caregivers. Researchers will measure changes in symptoms, expressed emotion, and caregiver mood. The study includes …

This trial tests whether combining a video game exercise program (Nintendo Ring Fit Adventure) with Acceptance and Commitment Therapy (ACT) can reduce depression and anxiety in breast cancer survivors. About 120 participants will be randomly assigned to the combined program, ACT …

This trial tests whether a combination of pain education, guided imagery, and paced breathing—called the STEIN Protocol—can help people undergoing awake cataract surgery need less pain and anxiety medication. Participants wear open-ear headphones that play audio prompts every few…

This trial tests whether an internet-based program called PATH can help adults cope with depression, stress, and conflict. PATH combines problem-solving therapy, stress management, and conflict resolution training into interactive online modules. Anyone 18 or older can join, and …

This trial tests whether a culturally adapted, nurse-led program called COPE can improve the psychological wellbeing of primary caregivers of children with autism spectrum disorder in Pakistan. The program includes four weekly sessions focused on coping skills, emotional regulati…

This study tests whether a structured behavioral therapy called CBIT can help children and teens aged 10–17 with chronic tics (Tourette syndrome or persistent tic disorder) gain better control over their symptoms. Participants receive 8 weekly CBIT sessions, learning to replace t…

This study tests whether two non-prescription therapies—inhaled essential oils and a wearable TENS device—can help adults with chronic nausea and anxiety. Participants use the essential oil products as needed for 12 weeks, then switch to the TENS device for another 12 weeks, whil…

This pilot study tests whether an 8-week mobile app called MOMent can help mothers who are experiencing food insecurity build coping skills and reduce stress. The app uses techniques from cognitive behavioral therapy (CBT), including goal-setting, self-monitoring, and skill-build…

This trial tests whether six months of group singing can improve mood, quality of life, and language recovery in stroke survivors with aphasia, while also supporting their personal caregivers. Half of the participants will attend weekly singing sessions; the other half will recei…

This trial tests whether a 12-session trauma-focused cognitive-behavioral therapy called SEE FAR CBT can reduce PTSD symptoms in adults aged 18 and older. Participants attend weekly therapy sessions and complete questionnaires about PTSD, anxiety, and depression at the start, aft…

This study tests whether taking a daily probiotic supplement called Neuralli Mood for 90 days can help reduce stress, sleep problems, low mood, anxiety, and burnout in adults who experience these issues. Participants take two capsules each day and complete questionnaires before a…

This study tests whether participating in poetry workshops can reduce anxiety and improve emotional well-being in adults with chronic digestive symptoms like dyspepsia and gastroparesis. Participants either attend facilitated group workshops or receive a poetry manual to write on…

This study tests a digital app called StartHjelp that provides information about mental health treatment, patient rights, and self-help strategies to adults waiting for outpatient care. The goal is to see if using the app improves patient satisfaction, engagement, and knowledge c…

This trial tests whether a medical-social collaboration model—where trained clinical social workers deliver CBT-based stepped-care interventions—can reduce depressive symptoms in middle-aged and older adults awaiting their first psychiatric appointment. Participants receive eithe…

This study tests whether a short educational program can help adults with ADHD feel more satisfied and confident in managing their condition. The program combines group sessions with digital materials, covering self-help tools and treatment options. Researchers will compare this …

This study tests a short, focused cognitive-behavioral therapy (CBT) called Brief SEE FAR CBT against standard dynamic psychotherapy for adults with posttraumatic stress disorder (PTSD). Participants in the CBT group receive 6 weekly sessions targeting intrusive PTSD symptoms, th…

This trial tests whether a support package for relatives of patients dying in the emergency department can lower the risk of prolonged grief disorder. The package includes a meeting with the healthcare team, written information on palliative care, proactive communication, a dedic…

This early-stage trial tests whether Floatation-REST — floating in a shallow, soundproof, light-free pool of Epsom salt water — can safely reduce post-traumatic stress symptoms and burnout in frontline healthcare workers and first responders. Fifteen participants will be randomly…

This trial investigates whether giving children aged 7 to 17 a sedative before general anesthesia improves their surgical experience. Participants receive either midazolam, dexmedetomidine, or a placebo before surgery. The study measures anxiety, pain, and overall satisfaction to…

This study tests whether a gentle, non-invasive brain stimulation technique called tDCS can help people recover language abilities after a stroke that causes aphasia. Participants receive 14 sessions of tDCS over 7 days combined with speech therapy. Researchers measure language i…

This study tests whether a gentle electrical stimulation device worn on the ear can help improve social, communication, and behavioral symptoms in adults with high-functioning autism. Participants use the device at home for 30 minutes a day, up to 5 times a week, for 3 weeks. The…

This pilot study tests a program called Heartsight, which provides educational modules to caregivers of children who have had a cardiac arrest. The goal is to see if the program is feasible and acceptable, and whether it can reduce caregivers' uncertainty, anxiety, depression, an…

This study explores whether a single session of transcranial magnetic stimulation (TMS) can reduce depression symptoms in adults with autism spectrum disorder. Researchers will use brain wave recordings (EEG) and eye-tracking to see how the brain responds to sad faces before and …

This study tests whether a device that gently stimulates the forehead during sleep can help children aged 8 to 12 who have ADHD linked to prenatal alcohol exposure. The device, already cleared for general pediatric ADHD, is used at home by parents each night for four weeks. Resea…

This trial tests a culturally tailored, peer-led program called SanaMente for rural Latino adults with chronic medical conditions and mild-to-moderate depression or anxiety. Over 6 to 8 weeks, trained bilingual peer mentors lead small group sessions focused on mental health, stre…

This study tests whether a special helmet that delivers focused ultrasound can safely and effectively calm overactive brain circuits in people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Participants receive two sessions of this …

This study tests whether a one-hour mindfulness-based education program given to new mothers within 24 hours of delivery can improve how they perceive their maternal role and reduce anxiety. Half of the 84 participants receive the mindfulness program plus standard discharge care,…

This study compares two ways to treat depression in cancer survivors: a mobile app called Moodivate that tracks activities and mood, and 8 sessions of telehealth therapy with a mental health provider. About 45 adults who have had cancer and currently feel depressed will take part…

This study tests an 8-week program called MH-POWER designed to help autistic college students manage stress, anxiety, and depression. The program combines cognitive behavioral therapy, acceptance and commitment therapy, and habit formation through weekly group sessions and daily …

This study compares word learning in late-talking toddlers (ages 2–3) who receive a behavioral treatment called VAULT. One group is taught words from categories they already know (like animals), while the other group learns words from less familiar categories. The goal is to see …

This study investigates whether an intensive compassion-based therapy program can reduce burnout and improve well-being in healthcare professionals. Around 180 doctors and nurses with symptoms of burnout, anxiety, depression, or stress will be randomly assigned to either an 8-ses…

This study aims to find the dose of bupivacaine that effectively relieves labor pain in 90% of women receiving an epidural. Pregnant women at term with significant pain who request an epidural will receive a lidocaine test dose followed by a specific bupivacaine dose. The goal is…

This study tests whether giving parents of NICU babies regular video calls (2-3 times a week) in addition to standard phone updates can reduce their stress and anxiety. Half of the parents receive the video calls; the other half get only routine updates. Stress levels are measure…

This study tests whether a full-spectrum cannabidiol (CBD) oil, taken under the tongue for 12 weeks, can reduce symptoms of major depressive disorder in adults who haven't improved with standard antidepressants. 120 participants will receive either the CBD oil or a placebo, while…

This study tests a program called SUPPORT, where trained peer specialists (fellow veterans) help veterans with serious mental illness (like schizophrenia or bipolar disorder) who are at high risk for suicide. Together, they create a personalized recovery plan that includes coping…

This trial tests whether cannabidiol (CBD) can reduce symptoms of post-traumatic stress disorder (PTSD) in adults. Participants take either CBD or a placebo for 8 weeks, and researchers measure changes in PTSD symptoms using standard clinical assessments. The study aims to see if…

This trial tests a program called CAARE that provides education, monitoring, and brief therapy to caregivers of young children hospitalized for a traumatic injury. The goal is to improve quality of life and reduce PTSD, depression, and behavioral problems in both children and the…

This study tests whether a 30-minute virtual reality session with nature scenes and music can reduce pain, anxiety, and improve comfort in people who just had hip replacement surgery. Participants choose from forest, beach, underwater, or outdoor footage. The goal is to see if VR…

This study investigates whether Manuka honey can help reduce pain after tonsillectomy (surgery to remove the tonsils). Adults undergoing the procedure will take either honey or a placebo syrup three times daily for 14 days, alongside standard pain medication. The goal is to see i…

This study tests whether recreational fishing (angling) can help people with schizophrenia feel better and improve their quality of life. Participants will take part in a structured fishing program alongside their usual care. Researchers will measure changes in symptoms, loneline…

This study tests whether a week of morning bright light therapy improves sleep, alertness, mood, and thinking in healthy university students. Participants use a 10,000-lux light box for 30 minutes each morning for one week, and their results are compared to a week with usual ligh…

This study tests whether wearing light therapy glasses for one hour each morning can reduce obsessive-compulsive disorder (OCD) symptoms in young adults (ages 18–35) who go to bed at 1 a.m. or later. Participants wear the glasses daily for five weeks, track their sleep, and compl…

This study tests whether a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) can reduce chronic PTSD symptoms in veterans. The stimulation is guided by functional MRI scans to target a specific brain region. Half of the 64 participants re…

This study tests whether giving children a sugary drink (maltodextrin) two hours before surgery can reduce their anxiety and improve recovery. Children aged 3 to 17 having day surgery will receive either the sugary drink or a plain drink like water or tea. Researchers will measur…

This pilot study tests whether the Voiceitt app can help people with speech impairments caused by conditions like cerebral palsy, stroke, ALS, or Parkinson's disease communicate more effectively. Participants use the app to see if it improves speech clarity and daily communicatio…

This study tests a new way to treat post-traumatic stress disorder (PTSD) using personalized brain stimulation. Researchers use an EEG to find the right frequency for each person, then apply transcranial magnetic stimulation (TMS) to the frontal lobe. The trial includes 20 vetera…

This study tests a group therapy program called the Unified Protocol for adults with emotional disorders such as anxiety, depression, and related conditions. The program teaches skills like emotional awareness, flexible thinking, and facing fears. Researchers want to see if it im…

This study tests whether a four-session mindfulness class (Primary Care Brief Mindfulness Training) can help veterans reduce symptoms of anxiety, depression, and PTSD compared to a problem-solving class. The classes are designed for primary care settings and focus on meditation, …

This trial tests whether starting PTSD treatment with one type of talk therapy and then switching to another based on early progress leads to better symptom relief. About 430 adults receiving care at federally qualified health centers will take part. The study compares different …

This study tests whether a brief form of talk therapy, called Prolonged Exposure for Primary Care (PE-PC), can reduce PTSD symptoms in first responders and frontline healthcare workers. Participants receive 4-6 weekly 30-minute sessions either by telehealth or in person, delivere…

This trial tests whether adding either dexmedetomidine or magnesium sulphate to the standard numbing medicine bupivacaine improves pain control after chest surgery. About 60 adults with cancer undergoing thoracotomy will receive one of three nerve-block combinations. The main goa…

This study compares two types of nerve blocks for pain relief in women undergoing breast cancer surgery. One group receives a single-level block, while another receives a two-level block, with some patients also getting the medication dexmedetomidine. The goal is to see which app…

This study tests whether using the soundBrilliance app—which combines enhanced music, natural visuals, and spoken guidance—can help people aged 13 and older manage anxiety, depression, and stress. Over 12 weeks, participants use the app at least 4 days per week and report their m…

This study explores whether a type of talk therapy called behavioral activation, delivered via video call, can help older adults who are involved with Adult Protective Services due to neglect or self-neglect. The therapy aims to reduce depression and apathy, and improve daily act…

This study tests whether taking photos of things related to well-being and discussing them with a therapist can help people with stress-related illness. Participants take pictures with their phone before sessions, and the therapist uses the photos to guide conversations about wel…

This study explores whether a mobile app called FlowMD can help adults with mild anxiety. Participants use the app for 1-5 minutes of guided breathwork each day for four weeks. Surveys measure changes in anxiety levels and how easy the app is to use. The goal is to see if this ap…

This study tests whether wearing a headset that delivers a flickering 60Hz white light for 30 minutes a day can help ease depression symptoms. Adults with major depressive disorder will use the device at home for three weeks. Researchers will measure how well people stick with th…

This study tests whether a version of Dialectical Behavior Therapy (DBT) skills training, adapted for autistic adults, is feasible and helpful for those with emotion regulation difficulties. The program uses simplified language, more visuals, autism-relevant examples, and hands-o…

This study tests whether a noninvasive brain stimulation technique called tDCS can reduce depression in people with multiple sclerosis. Participants use a headband-like device at home for 30 minutes a day over 30 days, while listening to mindfulness meditation. Half receive real …

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This study compares two types of speech therapy for people with aphasia, a language disorder often caused by stroke. One therapy, called Semantic Feature Analysis (SFA), helps people name objects by describing their features. The other adds metacognitive strategy training (SFA+MS…

This trial tests whether shining a specific type of near-infrared light on the forehead—called transcranial photobiomodulation (tPBM)—can improve attention and reduce impulsivity in adults with and without ADHD. Participants receive either active tPBM or a sham (fake) treatment f…

This study compares two ways of delivering cognitive processing therapy (CPT) to pregnant women with posttraumatic stress disorder (PTSD). One group receives standard weekly therapy sessions for 12 weeks, while the other gets an intensive schedule of 10 sessions over just 5 days.…

This study investigates whether breathing a 50:50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain and anxiety during insertion of a central venous catheter, a common but uncomfortable procedure. Adults aged 18 to 65 who have never used nitrous oxide will be randoml…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep monitoring, blood tests, and questionnaires to compare four groups: people with recent suicidal thoughts or attempts, those with past sui…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study aims to understand the genetic causes of brain development disorders, including Aicardi syndrome, polymicrogyria, and Dandy-Walker malformation. Researchers will analyze genetic data from 2000 participants with these conditions, all confirmed by MRI. The goal is to use…

This study looks at how changing sleep schedules affects attention, mood, and the internal body clock in teens aged 13-17 with ADHD. Over three weeks, participants follow different sleep patterns—including a short-sleep week and a week with extended sleep timed either to match or…

This study aims to learn more about childhood-onset behavioral, psychiatric, and developmental disorders by observing people of all ages who have these conditions, along with their family members. Researchers will collect medical histories, perform psychiatric assessments, and ma…

This study aims to see if people with major depressive disorder have lower levels of an enzyme called PDE4B in their brains compared to healthy volunteers. Researchers will use PET and MRI scans along with an experimental radioactive tracer to measure this enzyme. The study invol…

This study tests a new approach called RIGHTimeCPV, designed to help children with poor-prognosis cancer and their families talk more openly with doctors about the future. Participants choose a communication companion and attend a special visit to share their preferences. The goa…

This pilot study will compare the Clubhouse Model—a structured, community-based program where members work together to run the clubhouse—to standard outpatient care for adults with schizophrenia. Researchers will measure changes in thinking, daily functioning, and brain activity …

This study looks at children and teens ages 7-17 who have severe mood problems like chronic anger, sadness, or irritability, along with extreme tantrums. Researchers will use interviews, tests, and brain imaging to understand what happens in the brain. Up to 2,350 participants wi…

This NIH study aims to understand what causes depression in teenagers and how the brain changes with the condition. Researchers will compare depressed teens with healthy ones using interviews, computer tasks, and brain scans. Eligible participants may also receive free talk thera…

This study looks at how ketamine affects the brain in people with major depression and healthy volunteers. Researchers use brain scans, blood tests, and other measures to understand why a single dose works quickly but briefly. The goal is to find biomarkers that could lead to bet…

This study aims to find differences between organic tics (related to diagnosed disorders) and functional tics (caused by problems in brain-body communication). Researchers will use sensors to measure muscle activity and brain waves in 75 adults with tics and healthy volunteers. P…

This study looks at whether doulas with extra training in mental health support can help pregnant women in rural Montana feel more confident and less depressed. About 75 pregnant women will be split into three groups: one with a specially trained doula, one with a regular doula, …

This study follows 436 women undergoing hysterectomy for non-cancerous reasons to see if certain pre-surgery assessments can predict who will develop chronic pain lasting months after the operation. Researchers measure pain sensitivity using a pressure device on the shoulders, an…

This study tests whether showing an aphasia identification card helps healthy volunteers better understand a person with aphasia. 160 service workers will listen to sentences from a speaker with aphasia, with or without seeing the card first. Researchers will measure comprehensio…

This study follows 500 adults already receiving care for depression, bipolar disorder, or suicide risk at the NIH. Researchers will conduct weekly interviews and optional tests like blood draws and brain scans to track symptoms and treatment responses. The goal is to better under…

This study uses advanced MRI (3T fMRI) to look at brain activity in people who have or will have deep brain stimulation (DBS) implants. DBS is a treatment for conditions like Parkinson's disease, tremor, and obsessive-compulsive disorder. The researchers will scan participants un…

This study looks at whether a group support program is practical and helpful for female partners of men who have viewed child sexual abuse material. Researchers will check if 15-20 women can be recruited within a year and if they find the program useful. The goal is to understand…

This study looks at how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or no mood disorder. Over two years, participants wear activity monitors and complete smartphone diaries for up to 20 days at a time. The goal is…

This trial asks whether a gentle electrical current applied to the scalp during language lessons can speed up and improve how adults learn a new language. Healthy adults who are learning or planning to learn a language are randomly assigned to receive either real or sham (placebo…

This study explores whether dream yoga practices can improve sleep and reduce anxiety. About 70 healthy adults with mild anxiety will learn techniques using virtual reality and home sleep monitors. The goal is to understand how these practices affect brain activity and dreaming, …

This observational study looks at how the brain responds when watching others perform actions, focusing on the mirror neuron system. Researchers will measure brain activity in healthy adults and infants, including those at risk for developmental delays, using EEG and fNIRS. The g…

This study tests a 9-session program called Changing Lives and Changing Outcomes-9 for people with serious mental illness who have been involved with the legal system. The program is designed to help participants understand their mental health better and reduce their chances of f…

This study looks at whether a condition called alexithymia—difficulty recognizing and describing emotions—affects pain levels and quality of life in people with chronic pain who use a spinal cord stimulator. Researchers will ask 20 participants to fill out questionnaires about em…

This study builds a large French cohort of 1,000 people experiencing a major depressive episode to examine their sleep and circadian rhythms. Researchers will use sleep recordings (polysomnography) and psychiatric evaluations to identify distinct patient subgroups and potential b…

This study aims to find biological markers that predict how well people with major depressive episodes respond to light therapy. Researchers will treat 173 adults with unipolar or bipolar depression using a bright light box for 4 weeks. By measuring sleep, mood, and circadian rhy…

This trial tests a group-based program called Lev-g, designed to help adults with or without disabilities adopt healthier habits. The program includes three sessions plus a booster, using motivational interviewing and behavioral analysis to support change. Researchers will measur…

This study follows 1,000 children who have surgery for a brain tumor in the back part of the brain. Up to 1 in 4 of these children develop a condition called Cerebellar Mutism Syndrome, where they lose the ability to speak. Researchers want to understand why this happens and how …

This study will test an enhanced version of a suicide safety planning app called ViraSafe in 100 teens and young adults (ages 13-24) who have recently attempted suicide or had serious suicidal thoughts. The goal is to see if the app helps them engage more with coping skills and t…

This observational study will survey over 300 Ukrainian women to understand how war influences their decisions about pregnancy and childbirth, and their mental health during the perinatal period. Participants will complete questionnaires about their well-being, reproductive choic…

This study explores whether data from your smartphone can warn doctors when depression symptoms are about to return. Researchers will collect phone data from 320 adults who have been treated for depression and are currently well. They will compare this data with monthly mood ques…

This study follows people who received inpatient treatment for stress-related conditions like depression, adjustment disorder, or burnout. Researchers will track their health and work ability for up to three years after discharge, using online questionnaires. The goal is to under…

This study tests a new program for adults in prison who have both ADHD and substance use disorder. The program includes workshops to improve care and support. Researchers will check if the program is acceptable and if it improves quality of life.

This study looks at whether brain activity synchronizes differently in people with schizophrenia during social interactions. Researchers will compare 100 participants—some with schizophrenia and some without—as they chat and do tasks together while wearing EEG caps. The goal is t…

This study asks children aged 6-16, their parents, and clinicians to vote on the most important research topics in pediatric anesthesia and perioperative medicine. Over 1,000 participants in Switzerland will complete online surveys to create a ranked list of the top 10 priorities…

This study from Stanford University is looking at how a 6-week math training program changes brain activity and thinking skills in children with math learning disabilities (dyscalculia). About 180 children aged 6-12 will do math problems on a tablet at home and get weekly one-on-…

This study follows 130 adults undergoing surgery for stomach or esophageal cancer to see how often they experience postoperative delirium—a state of confusion and disorientation after anesthesia. Researchers will also check whether depression, frailty, poor nutrition, or muscle l…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This study tests whether a non-invasive electrical brain stimulation technique called TES-TI can temporarily alter sleep spindles—brain rhythms often reduced in schizophrenia. Researchers will apply the stimulation during sleep in 20 people (half with schizophrenia spectrum disor…

This study looks at whether listening to music before a medical procedure can influence heart rate variability (HRV), a measure of the heart's ability to adapt to stress, and whether it relates to anxiety and depression. About 120 adults scheduled for procedures at three hospital…

This study investigates whether transcranial magnetic stimulation (TMS), a non-invasive technique that uses magnetic pulses to stimulate brain areas, can influence the coupling between heart and brain activity in individuals with depressive tendencies. Participants will undergo b…

This trial compares an online training program (COPEWeb) to in-person training for behavioral health providers. The goal is to see if the online version is as effective at teaching providers to deliver a combined treatment for PTSD and substance use disorders. Providers will be r…

This study looks at whether learning about well-being can improve how romantic partners think and feel. About 2,000 couples with mild depression symptoms will take online surveys about their emotions and relationship satisfaction. The goal is to see if gaining knowledge about wel…

This study tests whether adding 8 weeks of mindfulness training to a single dose of psilocybin (the active ingredient in magic mushrooms) improves mental health more than psilocybin alone. Forty healthy adults who have never used psychedelics or done formal mindfulness training w…

This study looks at adults with spinal deformity to understand which factors—like pain, daily functioning, mental health, and frailty—most influence quality of life. It follows 320 people receiving either conservative care, first-time corrective surgery, or a reoperation, using q…

This study looks at how people with depression or anxiety respond to different types of psychotherapy—individual sessions or an online program. It aims to find clues that predict who benefits most from each approach. By understanding these factors, doctors may better match patien…

This study tests two group-based parenting programs—HOT DOCS for children 0-5 and DOCS K-5 for kindergarten through 5th grade—designed to help caregivers manage disruptive behaviors and reduce parenting stress. Researchers will enroll 800 caregivers and professionals who speak En…

This study looks at whether a simple eye test can predict how well people with treatment-resistant depression will respond to a brain stimulation therapy called TMS. Researchers will measure how the pupils react to light before and after TMS treatment in 44 adults. The goal is to…

This study looks at whether brain wave patterns and inflammation markers in the blood can help predict how well electroconvulsive therapy (ECT) works for people with severe depression that hasn't improved with medication. Researchers will measure these markers before and after EC…

This study looks at whether adjusting sleep timing and using bright light therapy can improve mood and sleep in perimenopausal women with depression. Researchers will have 120 women either advance or delay their sleep for one night, then use a light box for 30 minutes daily for t…

This study looks at two sedative drugs, remimazolam and midazolam, used to put older adults (65+) to sleep for non-cardiac surgery. The goal is to see which one offers better heart and blood pressure stability, faster recovery, and fewer complications like confusion after surgery…

This study looks at brain activity in 100 adults with major depression who are receiving a treatment called accelerated TMS. Researchers use a special brain scanner (TD-fNIRS) to see if patterns of brain activity can predict who will respond well to the treatment. Healthy volunte…

This study aims to understand how ketamine produces rapid antidepressant effects by using a special brain scan (GluCEST) to measure changes in glutamate, a key brain chemical. Ten adults with treatment-resistant depression will receive a single ketamine infusion and undergo imagi…

This study explores whether mild electrical stimulation of the spine can change how the brain processes body signals, which may be disrupted in major depression. Researchers will test different stimulation levels in 67 adults with depression to see if it affects brain activity an…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep issues. Researchers will track how insomnia develops over the first year, using questionnaires to measure sleep quality and severity. The goal is to understand what factors—like treatment type or em…

This study investigates how the gut-brain axis—the communication network between gut bacteria and the brain—might be involved in pediatric obsessive-compulsive disorder (OCD). Researchers will compare gut microbiome, blood metabolites, brain imaging, and EEG data from children wi…

This study looks at how six short, 15-minute self-regulation techniques — like exercise, breathing, aromatherapy, music, virtual reality, and tapping — affect the body and brain of one woman with ADHD and stabilized bipolar disorder. Researchers will measure heart rate, brain wav…

This study follows pregnant women and their children from the first trimester through toddlerhood to explore how stress, early social experiences, and genetics interact. Using simple at-home activities like questionnaires, video recordings, and cheek swabs, researchers will look …

This study will follow 15 people aged 5 to 50 with 7q11.23 microduplication syndrome, a rare genetic condition linked to autism and social difficulties. Researchers will track developmental milestones, social skills, and behavior using interviews and questionnaires. The goal is t…

This study follows 450 people with treatment-resistant depression who are starting or continuing treatment with either IV ketamine or Spravato (esketamine) nasal spray. Over five years, researchers will track how satisfied patients are with their treatment, how well it works, and…

This study examines the prevalence of neurodevelopmental disorders like ADHD and autism among youth who have committed crimes. Researchers will analyze records from juvenile offenders to explore how these conditions relate to the types and frequency of criminal behavior. The goal…

This study is testing whether a smartwatch can help predict when a person with bipolar disorder or major depressive disorder might experience a manic or depressive episode. Researchers will track 100 participants for a year, collecting data on heart rate, sleep, and activity leve…

This study investigates whether brain wave patterns (measured by EEG) and inflammatory markers in the blood can help predict how well older adults with depression or bipolar disorder respond to electroconvulsive therapy (ECT). Researchers will compare EEG recordings and blood sam…

Women who had preeclampsia are at higher risk for both depression and heart disease later in life. This study investigates whether antidepressant medication can improve blood vessel function in these women. Researchers will measure skin blood vessel responses in 40 women, compari…

This study explores whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can help improve language recovery in people who have lost speech abilities after a stroke. Researchers will also test the same stimulation in…

This study investigates whether markers of inflammation in the blood could serve as diagnostic or severity biomarkers across several psychiatric conditions, including bipolar disorder, schizophrenia, and depressive episodes with psychotic features. Researchers will collect blood …

This study interviews bereaved parents and oncologists to understand how they discussed uncertainty during a child's cancer treatment. The goal is to find better ways for doctors and families to communicate about what the future may hold. Participants include parents whose child …

This study follows adults with a suspected bone or soft tissue tumor to see how their stress and anxiety levels change at three critical moments: before biopsy, after learning the diagnosis, and when treatment begins. Participants fill out standard questionnaires about anxiety, d…

This study investigates whether reduced sensitivity to social rewards contributes to social anhedonia—a lack of pleasure from social interactions—in people who have recently experienced their first episode of psychosis. Participants, aged 18 to 35, will undergo brain scans while …

This trial tests whether training novice bronchoscopists using computer-generated 'digital twin' models of real patient airways — showing a wide range of normal anatomical variations — can help them learn the procedure faster than traditional training with a single, uniform airwa…

This study investigates whether people who use cannabidiol (CBD) regularly react differently to acute stress compared to those who do not. Healthy adults aged 21–70 who either use CBD daily or not at all will undergo a series of stressful tasks — including public speaking, mental…

This study investigates whether early-detection programs for psychosis can reduce the time people live with untreated symptoms and whether that leads to better long-term functioning. Researchers will follow adults newly diagnosed with schizophrenia-spectrum disorders in two Danis…

This study compares brain activity and parenting styles in children aged 7-12 with and without depression. It then tests whether these factors can predict how well a child responds to a 12-session family-focused therapy designed to build positive interactions and coping skills. P…

This study looks at whether adults with autism can reliably report their own personality disorder traits using a standard questionnaire. Researchers compare these self-reports with descriptions from someone who knows the participant well, such as a family member or partner. The g…

This study investigates whether immune inflammation in the blood and brain is linked to brain structure, function, and symptoms in people with schizophrenia. Researchers will follow 200 participants for three months, collecting clinical data, brain scans, and biological samples. …

This study tracks how tic symptoms change in 30 youth aged 12-17 with Tourette syndrome or chronic tic disorders. Participants receive 8 sessions of behavioral therapy (CBIT) and complete daily surveys, wear a device to track physiology, and perform weekly tasks. The goal is to i…

This study investigates how a person's genetic makeup influences their response to cannabis, including risk for addiction and psychosis. Healthy adults aged 21-60 receive either a very low or medium dose of THC (the active ingredient in cannabis) or a placebo intravenously. Resea…

This study tests a web-based decision-support tool designed to help families and doctors make shared decisions about whether a child should go on chronic home ventilation. Half of the participating families use the tool, while the other half receive usual care. Researchers then m…

This study tests whether a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) can strengthen connections between brain regions involved in emotion regulation in people with bipolar disorder. Participants, aged 24 to 65 with bipolar I or II…

This study follows about 800 internal medicine residents in Switzerland over several years to track their well-being, mental health, and career decisions. Participants complete annual surveys covering stress, burnout, depression, sleep, empathy, and work-life balance. The goal is…

This study tests a new type of talk therapy called Process Based Therapy (PBT) for people with depression or anxiety. Instead of a one-size-fits-all plan, PBT uses daily mood check-ins from a smartphone app to help therapists tailor treatment to each person's changing needs. The …

This study investigates whether microRNAs found in brain-derived particles in the blood can serve as biomarkers for schizophrenia. Researchers will compare blood samples from 80 people recently diagnosed with first-episode schizophrenia and 80 healthy volunteers, tracking changes…

This study investigates whether tiny particles called exosomes, released by brain cells and found in the blood, can serve as biomarkers for depression and suicide risk in adolescents. Researchers will analyze genetic material from these exosomes in 240 teenagers, including those …

This study looks at how alcohol and substance use affect people with severe mental illnesses like schizophrenia and bipolar disorder. Researchers compare those who also have substance use problems with those who do not, measuring things like hospitalizations, medication needs, em…

This study uses transcranial magnetic stimulation (TMS) to investigate how the brain processes language in people who have had a stroke and developed aphasia, as well as in healthy volunteers. Participants receive targeted magnetic pulses to specific brain areas while performing …

This study tests whether a special training program called mastery learning can improve how anesthesiology residents handle difficult conversations with patients and families. Residents are randomly assigned to either the mastery training or standard learning. Researchers then me…

This study investigates whether restricting access to social media apps on smartphones for three months can improve anxiety and depression in adolescents aged 10 to 14. Half of the 500 participants will have no social media apps on their phones, while the other half will use them…

This study tests a training program for healthcare providers in Michigan to improve how they communicate with and care for Black and Hispanic pregnant individuals. The goal is to increase provider confidence and awareness of community resources, which may help reduce racial dispa…

This study looks at how common depression, anxiety, and behavior problems are in children with cystic fibrosis (CF) aged 18 months to 11 years. Researchers will use parent and child questionnaires to track these issues over time. The goal is to understand the mental health needs …

This study follows people with treatment-resistant depression who have already responded to transcranial magnetic stimulation (TMS). Researchers want to understand how long the antidepressant effect lasts and what factors—like brain plasticity, heart-brain coupling, or inflammati…

This study investigates how depression and antidepressants influence the way older adults update their beliefs about future events. Researchers compare 31 patients aged 65+ with major depression who are switching antidepressants to 31 healthy volunteers of the same age. Participa…

This study looks at whether parents of people with bipolar II disorder or major depressive disorder have certain personality traits (called Type D, which involves negative emotions and social inhibition) and lower life satisfaction. Researchers compare these parents to parents of…

This study looks at whether anxiety or depression makes asthma harder to control and aims to build a model that predicts when a serious asthma attack might happen. Researchers will follow 256 people with asthma for up to two years, tracking their symptoms, mental health, and lung…

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study creates a large registry of people with Rett syndrome, a rare genetic disorder that causes severe intellectual and physical disabilities. Researchers will collect information from doctors and caregivers to understand how the disease progresses over time. The goal is to…

This study aims to create a risk score that uses information from electronic medical records to predict the chance of developing dementia within 5, 9, or 13 years in older adults with depression. Researchers will analyze data from 44 participants aged 50 and older who have a depr…

This study investigates how depression and cannabis use together affect brain circuits involved in reward and pain in young people living with HIV. Researchers will use MRI scans and questionnaires to measure brain activity, mood, and substance use. The goal is to understand why …

This study examines whether a person's personality traits before they got sick are linked to the thinking and behavior problems seen in certain brain disorders. Researchers will ask caregivers about the patient's personality from the 10 years before the illness started. The goal …

This study investigates why some adolescents act impulsively when experiencing negative emotions, a trait called negative urgency. Researchers will measure brain cell communication using transcranial magnetic stimulation and EEG in teens aged 13-21 with depression and suicidal th…

This study compares three types of exercise programs—traditional physical activity, virtual reality, and video game-based—to see how they affect physical fitness and attention in healthy adolescents aged 10-18. Participants will be split into three groups and follow their assigne…

This study follows 1,200 families who already have a child with autism (high-risk group) and 500 families from the general population (low-risk group) starting from early pregnancy. Researchers collect biological samples and survey data to explore how genetics, environment, diet,…

This study investigates whether a clinical test using lorazepam (Ativan) and brain imaging can identify veterans with PTSD who might benefit from medications that boost GABA signaling. Researchers aim to validate a computational method to distinguish subgroups of PTSD patients ba…

This study investigates how the gut and brain communicate in people with Irritable Bowel Syndrome (IBS) who also experience anxiety or depression. Researchers will compare 100 IBS patients with anxiety or depression to 100 healthy volunteers using brain scans, stool samples, and …

This study looks at how depression and very early (preclinical) Alzheimer's disease affect driving habits in adults aged 65 and older who still drive regularly. Participants will have their driving tracked with a GPS device and undergo brain scans to measure Alzheimer-related pro…

This study compares two strategies for teaching new words to autistic children aged 4 to 10: repeating words (re-study) versus quizzing after labeling (repeated quizzing). Researchers want to see which method helps children learn nouns and adjectives better and whether they can u…