Can a Three-Day pill ease postpartum depression?
NCT ID NCT07721961
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether an experimental drug called MI078 can safely reduce symptoms of postpartum depression in new mothers. About 200 women aged 18 to 45 with a recent diagnosis of major depression linked to childbirth will receive either MI078 capsules or a placebo for three days. Researchers will measure changes in depression scores using standard rating scales to see if the drug offers meaningful relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an experimental drug called MI078
- What this could lead to
- If it works, this could offer a new, fast-acting treatment option for postpartum depression, a condition that affects many new mothers.
- What could go wrong
- This is an early-phase trial with only 200 participants, so results may not apply to everyone. The drug's safety and effectiveness are still unproven, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Affiliated Hospital of Zunyi Medical University
RECRUITINGZunyi, Guizhou, China
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Beijing Anding Hospital, Capital Medical University
RECRUITINGBeijing, China
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Beijing Huilongguan Hospital
RECRUITINGBeijing, China
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Chongqing Three Gorges Hospital
RECRUITINGChongqing, Chongqing Municipality, China
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Gansu Provincial Hospital of Traditional Chinese Medicine
RECRUITINGLanzhou, Gansu, China
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Ganzhou Third People's Hospital
RECRUITINGGanzhou, Jiangxi, China
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Guangxi Zhuang Autonomous Region Brain Hospital
RECRUITINGLiuzhou, Guangxi, China
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Guizhou Provincial People's Hospital
RECRUITINGGuiyang, Guizhou, China
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Hainan Anning Hospital
RECRUITINGHaikou, Hainan, China
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Hunan Brain Hospital
RECRUITINGChangsha, Hunan, China
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Huzhou Third People's Hospital
RECRUITINGHuzhou, Zhejiang, China
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Kangning Hospital Affiliated to Ningbo University
RECRUITINGNingbo, Zhejiang, China
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Linfen Central Hospital
RECRUITINGLinfen, Shanxi, China
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Renmin Hospital of Wuhan University
RECRUITINGWuhan, Hubei, China
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Shandong Daizhuang Hospital
RECRUITINGJining, Shandong, China
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Shiyan Taihe Hospital
RECRUITINGShiyan, Hebei, China
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Sichuan Provincial People's Hospital
RECRUITINGChengdu, Sichuan, China
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The Affiliated Hospital of Chongqing Medical University
RECRUITINGChongqing, Chongqing Municipality, China
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The Affiliated Hospital of Southwest Medical University
RECRUITINGLuzhou, Sichuan, China
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The First Affiliated Hospital of Jinan University
RECRUITINGGuangzhou, Guangdong, China
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The First Affiliated Hospital of Nanchang University
RECRUITINGNanchang, Jiangxi, China
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The First Affiliated Hospital of Ningbo University
RECRUITINGNingbo, Zhejiang, China
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The First Affiliated Hospital of Zhengzhou University
RECRUITINGZhengzhou, Henan, China
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The First Hospital of Hebei Medical University
RECRUITINGShijiazhuang, Hebei, China
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The Second Affiliated Hospital of Anhui Medical University
RECRUITINGHefei, Anhui, China
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The Second Affiliated Hospital of Xinxiang Medical University (Henan Mental Health)
RECRUITINGXinxiang, Henan, China
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The Second Hospital of Hebei Medical University
RECRUITINGShijiazhuang, Hebei, China
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Wuxi Mental Health Center
RECRUITINGWuxi, Jiangsu, China
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Xi'an Mental Health Center
RECRUITINGXi’an, Shanxi, China
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Xiamen Xianyue Hospital
RECRUITINGXiamen, Fujian, China
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Xingtai People's Hospital
RECRUITINGXingtai, Hebei, China
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Xuzhou Dongfang Hospital
RECRUITINGXuzhou, Jiangsu, China
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Zhaoqing Third People's Hospital
RECRUITINGZhaoqing, Guangdong, China
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Zhengzhou Ninth People's Hospital
RECRUITINGZhengzhou, Henan, China
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Zhumadian Psychiatric Hospital
RECRUITINGZhumadian, Henan, China
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Zhuzhou Third Hospital (Zhuzhou Psychiatric Hospital)
RECRUITINGZhuzhou, Hunan, China
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More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A 45-Minute talk after childbirth could cut postpartum depression risk
- Iron infusion after C-Section may cut depression risk
- New virtual program aims to prevent postpartum depression in LGBTQ+ parents
- Text messages and videos aim to stop postpartum depression before it starts
- Mothers share their stories: did therapy groups help after baby blues?
- Could a nasal spray before labor ward off postpartum depression?