Postpartum depression

This study compares IV iron to oral iron pills for treating moderate anemia after a C-section. The goal is to see if better iron levels can reduce the risk of postpartum depression. About 2,860 women will take part, and their mood will be checked 8 weeks after delivery.

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study tests a program called Tunawiri (meaning 'thrive') that adds mental health screening, counseling, and support to regular HIV care for pregnant and postpartum women in Kenya. The goal is to improve depression, anxiety, and HIV treatment success. Nine hundred women will …

This study tests a program called Enhanced Friendship Bench that combines problem-solving therapy with HIV support for pregnant women in Malawi who have HIV and depression. About 400 women will take part to see if the program reduces depression symptoms and helps them stay in HIV…

This study tests a gamified mobile health app designed to reduce suicide risk in adults with mental disorders after they leave the hospital. Researchers will enroll 640 participants in Shenzhen, China, and use game-like features to encourage treatment adherence and follow-up visi…

This study tests a couple-based problem-solving therapy for pregnant women living with HIV who also have depression. The goal is to improve their mental health and help them stick to their HIV medication, which prevents passing the virus to their baby. The trial will enroll 180 c…

This study tests whether a non-invasive brain stimulation technique called TMS can help people with mental illness quit smoking. Forty daily smokers with psychiatric conditions will receive either TMS or standard care. The goal is to see if TMS is practical and effective in real-…

This study tests a community-based home visiting program for high-risk postpartum women in five rural Mississippi counties. The program uses the PEN-3 model to build trust and connect mothers with healthcare. Researchers will measure whether the program reduces emergency room vis…

This study is testing whether a mobile app can help detect postpartum depression early in pregnant women. Researchers will follow 120 women for 6 months, using daily mood questions and monthly surveys through the app. The goal is to understand how symptoms change over time and to…

This study is testing a new blood test called the Enlighten Device to see if it can predict which pregnant women will develop postpartum depression (PPD). Researchers will collect blood from 500 pregnant women in their third trimester and then follow them for 6 months after birth…

This study is testing a new test called the Enlighten Device that uses a blood or saliva sample to predict if a pregnant woman will develop postpartum depression (PPD) after giving birth. Researchers will enroll 1,000 pregnant women and follow them for three months after delivery…

This study tests a simple writing exercise for new mothers who had a stressful childbirth. In the days after giving birth, participants write about their experience for 15 minutes a day for three days. The goal is to see if this can prevent post-traumatic stress disorder (PTSD) a…

This study looks at whether the ROSE program, which has been shown to prevent about half of postpartum depression cases in women at higher risk, can work for all new mothers. Researchers will enroll 2,320 pregnant women from a large health system in Detroit to see if offering the…

This study tests whether a virtual group program called Mothers and Babies can prevent postpartum depression in immigrant Latinas who are at risk. About 300 pregnant women and new mothers will either join the program via Zoom or receive usual support services. Researchers will tr…

This study is testing a program called ROSE, which includes six group sessions and one individual session for pregnant women. The goal is to see if it can prevent postpartum depression, reduce stress, and increase social support. About 308 pregnant women receiving care at a speci…

This study tests whether an online sleep improvement program for pregnant women can reduce stress and prevent postpartum depression and anxiety. Researchers will enroll 114 women early in pregnancy and track their sleep, stress hormones, and mood for months after birth. The progr…

This study tests a smartphone app called VoiceLove that lets mothers of babies in the NICU record voice messages for their infant. Researchers want to see if using the app helps reduce symptoms of postpartum depression compared to standard care. About 150 mothers will take part, …

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study compares a standard mobile cognitive behavioral therapy (CBT) program to a personalized version that teaches skills faster. About 100 adults aged 18-25 with anxiety, depression, or bipolar disorder will use the Maya app for 20 minutes, twice a week, for six weeks. The …

This study tests whether a fast, non-invasive brain stimulation method called iTBS can help women with post-partum depression. About 40 new mothers will receive up to 10 or 12 sessions per day over 5-6 days. The goal is to see if the treatment is practical, well-tolerated, and re…

This study is testing a mobile app called MAYA that teaches cognitive behavioral therapy (CBT) skills to help older adults manage anxiety and depression. About 60 participants aged 40 and older with an anxiety or depressive disorder will use the app for at least 20 minutes, twice…

This study tests whether a quick form of brain stimulation called SAINT can reduce symptoms of postpartum depression better than a fake treatment. It will include 192 women who are up to 12 months after giving birth and whose depression hasn't improved with standard care. The mai…

This large study tests a collaborative care model (COMPASS+) that adds a mental health care manager to regular obstetric care for pregnant and postpartum people. The care manager offers short-term therapy, tracks symptoms, and works with doctors and a psychiatrist to create perso…

This study tests a program called SUPERCEDE, which provides intensive case management to veterans who are at risk for suicide and receive care both from the VA and outside community providers. The goal is to improve care coordination, reduce suicidal thoughts, and improve daily f…

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This study tests a program called BRIDGE for mothers with depression and their children aged 3-7 who have attention or behavior problems. The program aims to improve children's self-control and reduce problem behaviors by supporting mothers' mental health. About 60 families will …

This study tests whether a text-message based chatbot support program can reduce symptoms of postpartum depression in people of color who recently gave birth. About 156 participants will either get the chatbot or usual care. The goal is to see if the chatbot lowers depression sco…

This study is testing whether a virtual reality version of a therapy exercise is practical and helpful for adults (ages 18-65) with psychiatric disorders. Participants will try one VR session and answer questions about their experience. The goal is to see if this approach is acce…

This study tests a text message program for new parents in Nova Scotia. 332 first-time parents will either receive daily texts for 6 weeks with tips on baby care and mental health, or no texts. Researchers will compare confidence, anxiety, depression, and co-parenting between the…

This study tests an AI chatbot called Aurora that guides people through creating a personal life story to improve emotional well-being and identity. It includes healthy adults, adults with mental health conditions in residential care, and older adults aged 65+. The chatbot is not…

This study tests a brief group therapy that teaches people to better understand their own and others' thoughts and feelings (called mentalization). One hundred adults with anxiety or depression will be randomly assigned to this new therapy or to standard group therapy. Researcher…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered over video for people in New York who struggle with worry, overthinking, or being hard on themselves. The goal is to see if the therapy helps people better manage their emotions and fee…

This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…

This study tests a group program called D-MCT that helps women with postpartum depression improve how they think about their own thoughts. About 96 women who have given birth and have depression will either take the program or receive standard care. The goal is to see if the prog…

This study looks at how well and how safely a new sleep medication, lemborexant, works for people who have both a mental health condition and trouble sleeping. About 121 adults will take the drug for 8 weeks, and researchers will track changes in their sleep quality and any side …

This study is testing whether two devices used together can help new mothers with both depression and urinary incontinence. One device uses magnetic pulses to stimulate brain areas linked to mood, while the other strengthens pelvic floor muscles with electromagnetic energy. Sixty…

This study tests two types of talk therapy—cognitive behavioral therapy (CBT) and interpersonal therapy (IPT)—for postpartum depression in mothers whose babies are in the NICU. About 72 mothers will receive either 4 weeks of one therapy or 8 weeks of both, to see which approach r…

This study looks at whether watching Netflix or Disney shows in a small group for 90 minutes each week, over 6 weeks, can improve emotional awareness and reduce anxiety and depression. About 70 adults who have been in mental health treatment for at least 6 months will take part. …

This study follows 200 people with postpartum depression who are starting zuranolone (Zurzuvae). Researchers will use online surveys to track symptom changes at 15, 45, and 90 days. The goal is to see how symptoms improve in everyday conditions, not in a controlled lab setting.

This study tests whether adding an internet-based therapy program (iCARE) to standard care helps reduce symptoms of postpartum depression more than standard care alone. About 352 new mothers in Denmark who gave birth within the last 6 months and have mild to moderate depression s…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests whether sailing can help people with psychiatric disorders feel better. Forty adults in France will either take sailing lessons or continue their usual care. Researchers will measure changes in quality of life, mental well-being, and self-esteem to see if sailing…

This study tests whether four short, guided conversations with a trained nurse can lower anxiety and improve breastfeeding confidence in mothers who have a planned C-section. About 160 women will be randomly assigned to either standard care or standard care plus these nurse-led c…

This study tests a stepped-care program to help pregnant women and new mothers who have depression or anxiety. About 3,000 women in Kenya will be screened and offered treatment that increases in intensity as needed. The goal is to improve mood and quality of life.

This study tests whether a special blue light device can improve mood in women who are 4-6 weeks postpartum and have depression or anxiety. Half of the 50 depressed participants will use the blue light, the other half a dim placebo light. The researchers will also track sleep and…

This study tests whether providing doula support and care coordination to parents of preterm babies in the NICU can reduce stress, depression, and anxiety. Twenty English-speaking mothers of babies born before 34 weeks are being recruited. The doula helps connect families to ment…

This study tests a new type of talk therapy called Engage & Connect for mothers with postpartum depression. The therapy focuses on helping moms plan and do rewarding social activities to reduce feelings of isolation. Sixty participants will receive either this new therapy or a st…

This study tests a mindfulness program called 'Mindful with your Baby' for mothers with babies aged 5-9 months who have postpartum depression, anxiety, or stress. The program includes 8 group sessions where mothers practice mindfulness with their babies. Researchers will measure …

This study tests whether adding social cognitive training—like learning to understand another person's point of view—to standard cognitive behavioral therapy (CBT) helps teens with depression feel better. Researchers will compare two groups of 82 teens aged 13-17: one gets CBT pl…

This study tests an accelerated form of Transcranial Magnetic Stimulation (TMS) for depression in pregnant and postpartum individuals. Instead of daily sessions for weeks, participants receive multiple treatments over just 5 days. The goal is to see if this faster approach is saf…

This study will carefully examine the physical and mental health of 100 adults admitted to NHS mental health wards. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like bipolar disorder, schizophrenia, depression, and persona…

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

This study tests whether spending more than 2 days in a kangaroo mother care (KMC) ward—where mothers hold their low birthweight babies skin-to-skin and get breastfeeding support—can lower the risk of postpartum depression. About 1,900 mothers and their preterm infants in Zambia …

This study compares two ways to help adults with mental health issues get follow-up care. One group gets usual care after an emergency room visit, while the other uses a new system that books a psychiatrist appointment within 48 hours through their general doctor. Researchers wil…

This study looks at whether a tool called the Decision Helper helps people with mental health conditions take a more active role in choosing their treatment. About 62 adults in Danish outpatient mental health clinics will have their consultations recorded and analyzed. The goal i…

This study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…

This study aims to improve postpartum care for high-risk women in the Mississippi Delta, especially Black women. Researchers will test a community-based program that focuses on building trust, improving health literacy, and strengthening family support. The goal is to reduce seve…

This study aims to improve suicide prevention for people who move between healthcare and the criminal-legal system. Researchers will link health records, Medicaid data, and jail booking information to identify individuals at risk and coordinate care. Over 1,000 adults with past p…

This study looks at whether asking new mothers a few questions within 48 hours of an unplanned C-section can predict who will develop post-traumatic stress disorder (PTSD) related to childbirth. Researchers will follow 420 women for three months, comparing early screening scores …

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily diaries, and brain scans to understand these connections. The goal is to…

This study follows 415 people with difficult-to-treat depression for 5 years after they joined an earlier genetics study. Researchers will review medical records and registry data to see how patients' depression changes over time, including suicide attempts and treatment response…

This study looks at whether having your expectations for labor pain relief met or not affects your chance of developing postpartum depression. Researchers will follow 3640 women planning a vaginal delivery and compare depression rates six months after birth between those whose pa…

This study looks at why people with mood disorders may be at risk for suicide. Researchers will collect blood, urine, and survey answers from 300 participants to find patterns and build a model that predicts suicide risk. The goal is to better understand the factors involved so d…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study tests whether a mobile app with health education and support groups can improve the health of new mothers and their babies. Researchers will enroll 2,100 pregnant women in India and track outcomes like breastfeeding, depression, and family planning. The goal is to see …

This study follows 600 pregnant women with gestational diabetes to see how depression and diabetes affect each other during pregnancy and after birth. Some participants will receive short health education videos about diet, exercise, and support. The goal is to understand the con…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study will measure how many women at a high-risk pregnancy clinic experience postpartum depression. Researchers will use a standard questionnaire called the Edinburgh Postnatal Depression Scale (EPDS) to screen 100 women who gave birth 4 weeks to 6 months ago. The goal is to…

This study is looking at how a non-invasive brain stimulation treatment called TMS changes the brain in people with depression. 100 adults will receive 20 TMS sessions over four weeks and have MRI scans at several points. The goal is to find brain imaging markers that can predict…

This study tests whether a special eye-tracking device (Gaize) can identify changes in eye movement patterns caused by long-term use of psychiatric medications. Researchers will observe 50 adults with conditions like ADHD, depression, or anxiety who have been on medication for ov…

This study looks at how support from a partner influences parenting confidence and depression risk in first-time mothers. Researchers will survey 193 women who are within 12 months of giving birth. The goal is to understand whether partner support helps protect against postpartum…

This study aims to see if the Edinburgh Postnatal Depression Scale (EPDS), a questionnaire already used for mothers, also works for fathers. Researchers will enroll 1,000 French fathers with babies 10 days old or younger. Participants fill out online questionnaires and some also …

This study looks at whether a recovery-focused program can help people with severe mental illness living in supported housing. About 72 participants will either receive the new program or standard care. The goal is to see if focusing on personal goals improves daily functioning a…

This observational study follows 500 first-time mothers to understand how depression during pregnancy and after childbirth influences how they feed their babies. Participants fill out questionnaires four times from 24 weeks of pregnancy until 6 months after birth. The study track…

This study looks at whether doulas with extra training in mental health support can help pregnant women in rural Montana feel more confident and less depressed. About 75 pregnant women will be split into three groups: one with a specially trained doula, one with a regular doula, …

This study is creating a program called START-VET to help veterans with mental illness or substance use disorders who have recently left prison. Researchers will work with 20 veterans to develop transition materials and tools. The goal is to improve quality of life and reduce cri…

This observational study follows 300 adults receiving strategic psychotherapy—a short-term, goal-focused talk therapy—in private practice. Participants fill out questionnaires about their symptoms and well-being before and after treatment. The goal is to see if this therapy leads…

This study is testing a mobile app called TrueBlue that automatically measures mood in pregnant women and new mothers. Researchers want to see if the app is safe, easy to use, and agrees with standard depression questionnaires. About 125 participants in Nottinghamshire, UK, will …

This pilot study is testing whether a simple saliva test can help doctors prescribe mental health medications more safely and effectively. 200 adults in Manitoba who are starting or changing psychiatric drugs will provide a DNA sample. The results will be shared with their doctor…

This study looks at whether training psychiatric care teams to talk about sexual health with young patients (ages 15 and up) increases those conversations. Researchers will survey 770 teens hospitalized for psychiatric disorders about their sexual health and any side effects from…