Postpartum depression

This trial tests whether an experimental drug called KH607 can reduce symptoms of postpartum depression in adult women. Participants take the drug or a placebo once daily for two weeks. The study measures changes in depression scores to see if KH607 offers a safe and effective sh…

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

This study tested a blended collaborative care model that uses telemedicine to integrate mental health treatment into primary care at smaller VA clinics serving rural veterans. Researchers enrolled 318 veterans who screened positive for depression, alcohol use disorder, or PTSD. …

This study tests a voice-analysis device designed to help clinicians screen for moderate to severe depression in adults. About 1,600 English-speaking adults aged 22 and older will record their voices, and the device's screening results will be compared with a standard clinical in…

This trial tests whether a group prenatal care model that includes social services can improve maternal mental health and reduce preterm birth compared to standard individual care with added services. Pregnant women eligible for Medi-Cal in central California are randomly assigne…

This trial tests whether a one-day online workshop based on cognitive behavioural therapy (CBT) can reduce the risk of postpartum depression and anxiety. Pregnant women in their third trimester who have a history of depression but are not currently depressed will be randomly assi…

This study tests whether virtual prenatal yoga classes can prevent postpartum depression in pregnant women who have a history of depression. About 62 women will be randomly assigned to either take yoga classes or receive standard care. Researchers will track depression symptoms a…

This study tests a simple writing exercise for new mothers who had a stressful childbirth. In the days after giving birth, participants write about their experience for 15 minutes a day for three days. The goal is to see if this can prevent post-traumatic stress disorder (PTSD) a…

This study tested whether personalized, intensive nursing follow-up (by phone, home visits, or hospital consultations) after a suicide attempt could prevent another attempt or crisis in people with mood disorders. 380 participants were followed for one year. The goal was to see i…

This study looked at how to keep a program called ROSE, which prevents postpartum depression, running in clinics that serve low-income pregnant women. Researchers tested different levels of support—like coaching—to see what clinics need to keep offering the program long-term. The…

This study tested a program called "Parents and Babies" to see if it could prevent depression in pregnant women. The program is an online course with phone support. 510 pregnant women with mild to moderate depression symptoms took part. The goal was to see if the course plus phon…

This completed study tested whether a smartphone app called InBloom could help prevent postpartum depression in pregnant people at risk. 152 participants were randomly assigned to use the app or attend a weekly group program called ROSE. The study measured depression rates and se…

This study tested a trauma-informed program to prevent postpartum depression in women living in earthquake-affected regions of Türkiye. The program included education, emotional support, and coping skills, delivered by healthcare workers. 106 women took part, and the study measur…

This study tested a behavioral program called PREPP, which provides coaching sessions to pregnant women at risk for postpartum depression. The program focuses on improving infant sleep and reducing fussiness, aiming to lower depression risk. 216 women participated, receiving eith…

This study tested a wearable morning light device (Re-Timer) for women with postpartum depression. 95 women wore either bright or dim light glasses for 60 minutes each morning for 5 weeks. Researchers measured changes in depression symptoms, sleep, and body clock timing. The goal…

This study tested a program that combines mindfulness training, music listening, and video counseling to help new mothers manage depression and persistent pain after childbirth. The program was designed for use in outpatient care and includes digital tools. 1,720 healthy women wh…

This study tested an experimental oral drug called NORA520 in 93 women with severe postpartum depression. Participants took the drug or a placebo for just 3 days. Researchers measured how well it reduced depressive symptoms, checked for side effects, and looked at how much of the…

This study tested whether a 12-session parenting group therapy, called the Connecting and Reflecting Experience (CARE) program, is helpful and doable for new parents struggling with postpartum depression or anxiety. Seventeen parents of babies aged 3 to 12 months took part. The g…

This study tests a therapy called the Unified Protocol, designed to help people with emotional disorders like anxiety and depression by improving emotional regulation. Researchers compare delivering the therapy in online group sessions versus in-person group sessions to see if bo…

This study tests whether adding passive sensing technology (like smartphone data) to a standard counseling program helps community health workers better treat postpartum depression in low-resource settings. The trial compares the digital-enhanced approach to standard counseling a…

This study tested a new capsule called MI078 in 72 women with postpartum depression. The women took the drug or a placebo for 3 days. Researchers measured depression scores to see if the drug helps symptoms and to find the best dose. The trial is complete, and results will show i…

This study tested whether adding dog-assisted therapy to usual care helps teens aged 12-18 with mental health issues like anxiety, depression, and emotional dysregulation. 70 teens in a day hospital were randomly assigned to either get dog therapy plus usual care or usual care al…

This study looked at whether adding supervised Pilates exercises and structured prenatal education to standard care could reduce depressive symptoms, low back pain, and labor pain in first-time mothers. 85 pregnant women participated, with some attending the program and others re…

This study tested an online group program called Healthy Minds for people on sick leave due to depression, anxiety, or adjustment disorders. 123 participants either joined the 8-week program or received standard care. Researchers tracked their return to work, symptoms, and job fu…

This study looked at whether bright light therapy helps depression equally well in spring/summer compared to autumn/winter. Over 200 adults with depression received daily 30-minute light sessions for at least a week. Researchers measured symptom changes and followed up for three …

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This study tested a single injection of RE104 in 84 women with moderate-to-severe postpartum depression. The goal was to see if it reduces depressive symptoms better than a low-dose comparison. Results will help determine if this approach is safe and effective for new mothers.

This study tested a group therapy program called HUGS for mothers with postpartum depression. The goal was to see if it improves the mother-baby relationship compared to a playtime group. 104 mothers participated, and researchers measured bonding through video analysis. The thera…

This study tested a remote program called "And Now What?" to help prevent depression and anxiety in new mothers. 128 first-time moms in Chile took part, with some receiving the program plus usual care and others only usual care. The program included educational modules, messaging…

This study looked at three ways to manage pain after severe perineal tears (called OASIS) that can happen during vaginal delivery. Sixty-seven women received either a placebo, epidural morphine alone, or epidural morphine plus intravenous ketamine. The goal was to see which optio…

This study tested a digital mental health program for adults with depressive symptoms. The program includes nine online modules covering topics like positive thinking, relaxation, and healthy habits. Researchers compared results between people with diagnosed mood disorders and th…

This study tested a program that helps mothers with depression and their young children (ages 2-4) with behavior problems at the same time. The program combines parenting support with short videos to help moms cope with stress. Researchers wanted to see if treating both together …

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This study tested whether an 8-week mindfulness-based cognitive therapy (MBCT) program can reduce stress, anxiety, and depression in pregnant women at risk for psychological distress. 84 women participated, with some receiving MBCT and others getting usual care. The goal was to u…

This study tested an oral drug called LPCN 1154A in 90 women with severe postpartum depression. The goal was to see if it reduces depressive and anxiety symptoms better than a placebo. Participants took the drug or a placebo and were monitored for side effects and mood changes us…

This study tested whether giving pregnant trainee doctors extra support—like a smart bassinet, wearable breast pump, 24/7 online perinatal care, and a faculty mentor—could reduce burnout and improve wellbeing. 156 pregnant residents and fellows from four hospitals were randomly a…

This study tested whether an 8-week mindfulness program could reduce depressive symptoms in new mothers. 70 women in Hong Kong with mild to moderate postnatal depression were split into two groups: one took the mindfulness course, the other received a booklet with general advice.…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tested whether screening pregnant women for depression and anxiety and providing tailored online therapy could prevent these conditions after childbirth. Over 3,300 women participated, with some receiving screening and internet-based cognitive behavioral therapy (iCBT)…

This study tested whether eating dates or taking moringa can help new mothers with postpartum depression. 363 mothers with mild to severe depression and low breast milk production were split into three groups: dates, moringa, or a control group. After 28 days, researchers measure…

This study tested a therapist-guided online program called AMOR for pregnant women and new mothers with ADHD. 31 participants listened to podcasts and attended online group sessions. The goal was to see if the program was easy to use and helpful for managing ADHD, stress, anxiety…

This study tested a psychoeducational program based on the Watson Human Caring Model to reduce depressive symptoms and strengthen mother-infant bonding after childbirth. 88 pregnant women participated. The program covered topics like postpartum depression, baby care, and bonding.…

This study tested a brief 4-session Zoom program for first-time mothers to help them better understand their baby's thoughts and feelings. Sixty-six mothers with babies aged 1-5 months took part. The program teaches skills like recognizing emotions and reading baby cues. Research…

This study tested whether 8 weeks of psychodrama group sessions could help new mothers with babies in the NICU feel less depressed and more forgiving. 23 women took part, with 11 attending the sessions and 12 receiving no extra support. Results showed that the psychodrama group h…

This study looked at whether a 45-minute massage once a week for 4 weeks could improve mood and daily function in new mothers. 28 women within 6 months of giving birth took part. The goal was to see if massage, a drug-free option, could reduce depression and help mothers manage p…

This study tested a non-drug treatment called Personalized Integrated Chronotherapy (PIC) for depression during pregnancy and after childbirth. 120 pregnant women with major depression were randomly assigned to receive either usual care (medication or therapy) or PIC plus usual c…

This study tested whether online group singing classes could help new mothers with postnatal depression feel better. 37 mothers with babies up to 9 months old joined 6 weekly online singing sessions. The goal was to see if singing together could reduce depression symptoms, especi…

This study tested whether virtual reality (VR) sessions can help reduce anxiety and depression in people aged 12 to 25 who do not want to take medication. Forty participants completed five weekly VR sessions focused on relaxation, coping skills, and healthy habits. Researchers me…

This study tested a program called the Pregnant Moms' Empowerment Program (PMEP) for pregnant women who had experienced intimate partner violence in the past year. The goal was to see if the program could improve mothers' mental health, reduce the chance of further violence, and …

This study tested an experimental drug called SAGE-547 (brexanolone) given as a 60-hour intravenous infusion to 138 women with severe or moderate postpartum depression. The goal was to see if it could quickly reduce depressive symptoms compared to a placebo. Results showed that t…

This study tested a new 8-session psychotherapy called ChronoS in 67 adults with mood disorders (bipolar or depression) and chronic insomnia. The therapy focuses on sleep-wake awareness and habits. Researchers measured changes in insomnia severity using a standard questionnaire. …

This study tested a group version of a therapy program called the Unified Protocol for teens with emotional disorders like anxiety and depression. Thirty-one adolescents took part in 16 weekly group sessions at a public mental health center in Spain, along with three parent sessi…

This study tested the safety of a drug called brexanolone in 28 teenage mothers with postpartum depression. The drug was given as an IV infusion. Researchers monitored side effects and how the drug moved through the body. The goal was to see if it could be a safe treatment option…

This study tested a drug called SAGE-547, given as an IV infusion over 60 hours, to see if it could reduce symptoms of postpartum depression in women. 108 women with moderate to severe depression after childbirth took part. The goal was to measure changes in depression scores com…

This study tested an experimental drug called SAGE-547, given as an IV infusion, in 21 adult women with severe postpartum depression. The goal was to see if it could quickly reduce depression symptoms compared to a placebo. The trial was randomized and double-blind, meaning neith…

This study tested whether the drug ZULRESSO (brexanolone) can be safely given to women with postpartum depression in their own homes instead of a hospital. Fifty-two women took part. The main goal was to see if any side effects caused the infusion to be stopped or interrupted. Th…

This early study tested an experimental drug called SAGE-547 in 4 women with severe postpartum depression. The main goal was to check safety and how the drug works in the body, not to prove it treats depression. Because it was very small and had no comparison group, the results a…

This early study tested different doses of ketamine given through an IV to 12 women after cesarean delivery. The goal was to find a dose that is well-tolerated without serious side effects like dangerous changes in blood pressure or heart rate. The highest safe dose was found to …

This study tested whether personalized home visits by midwives during the first three months after birth can improve how new mothers function, their breastfeeding success, and their emotional resilience. 94 first-time mothers with healthy babies took part. The visits included edu…

This study looks at how a meditation program called TARA changes brain connections in teens aged 14 to 18 with mild or moderate depression. Researchers will use brain scans to see if meditation strengthens a key brain area and reduces depression symptoms. The goal is to understan…

This study investigates whether women who experience heavy bleeding (postpartum hemorrhage) after childbirth are more likely to develop depression, anxiety, or stress in the following year. Researchers will follow over 1,200 women who had a hemorrhage and compare them to those wh…

This study will measure how many women at a high-risk pregnancy clinic experience postpartum depression. Researchers will use a standard questionnaire called the Edinburgh Postnatal Depression Scale (EPDS) to screen 100 women who gave birth 4 weeks to 6 months ago. The goal is to…

This study looked at what makes it hard for new moms with postpartum depression to get mental health care, especially online. Researchers interviewed 10 women and then tested a virtual patient navigation program with 26 moms over 2 months. The goal was to see if the program was e…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This study follows couples who gave birth in either a midwifery-led birth unit or a standard obstetric unit in France. Researchers want to see if the type of care affects parents' mental health, especially post-traumatic stress, and the child's development up to two years later. …

This study looked at whether the natural bacteria in your gut are linked to mood changes after having a baby, including postpartum depression. Researchers collected samples from 30 pregnant women before and after delivery to see if certain gut bacteria patterns relate to emotiona…

This study used MRI brain scans and computer tasks to understand how people who attempted suicide make decisions. Researchers compared three groups: those who used violent means, those who used non-violent means, and healthy volunteers. The goal was to find brain activity pattern…

This study tested an 8-week parenting program called Circle of Security-Parenting for mothers with depression and infants showing signs of social withdrawal. Researchers compared it to standard care to see if it improves how mothers interact with their babies and helps the child'…

This study interviewed 12 mothers who had participated in HUGS mother-baby therapy groups for postpartum depression. The goal was to understand how the program affected their bond with their baby and their daily lives, 6 to 12 months later. Researchers used in-depth interviews to…

This study tested a free chatbot called Rosie that gives pregnant women and new moms instant, reliable health information from trusted sources. 400 minority women who were pregnant or had an infant under 6 months used the chatbot to ask questions and get answers. The goal was to …

This study looked at how common postpartum depression is among 401 mothers visiting health clinics in Mekelle, Ethiopia, and what factors might increase their risk. Mothers completed a questionnaire about their mood, social support, and health. The goal is to help doctors and pol…

This study tested a simple program to help new mothers who are at higher risk for health problems after giving birth. 220 Black mothers who delivered at the Hospital of the University of Pennsylvania took part. Some received a helpful pamphlet and a patient navigator they could c…

This study tested whether adding psychodramatic role-playing to standard childbirth classes could reduce postpartum depression and improve self-confidence and social support in first-time mothers. 57 pregnant women participated, with one group taking regular classes and the other…

This study looked at how keeping a diary helps parents and healthcare workers deal with the stress of having a baby in the neonatal unit. Fifteen parents of premature or low-weight babies and hospital staff took part. Researchers analyzed the diaries to understand emotions, stres…

This pilot study looked at whether giving donor human milk instead of formula to full-term babies whose mothers received antibiotics during labor could improve their gut bacteria and health. The study included 105 infants born vaginally at full term. Researchers compared the babi…

This study tested a program called IPS-MA, which helps people with mood or anxiety disorders find and keep jobs or return to school. 326 adults who were unable to work within three months took part. The goal was to see if this support, added to their usual treatment, helped them …

This study tested a mobile app called Baby2Home designed to help new families get the healthcare they need after childbirth. Over 600 parents and their babies took part, with some using the app and others getting usual care. The goal was to see if the app improved checkups, vacci…

This study followed 300 pregnant women to understand why some develop mood disorders like depression or bipolar episodes after giving birth. Researchers collected genetic, hormonal, and environmental data to find patterns that could predict these episodes. The goal is to better i…

This study enrolled 74 women with a history of postpartum depression to see if the sudden drop in hormones after childbirth causes mood symptoms. Researchers used hormone medications to simulate pregnancy and delivery in a controlled setting. The goal was to understand whether it…

This study looked at 200 women having planned C-sections to see if levels of a brain protein called BDNF in their spinal fluid and blood could predict postpartum depression. Researchers measured BDNF before surgery and checked for depression symptoms up to 42 days after birth. Th…

This study tested whether a psychoeducation program that includes fathers can reduce postnatal depression in first-time parents. 388 couples in Hong Kong were randomly assigned to either the program or usual care. Researchers measured depression, relationship quality, and quality…

This study looked at 48 adults with mood disorders and insomnia to see if a strong relationship with their therapist helped them get better results from a new type of therapy called ChronoS. The therapy combines sleep scheduling, mindfulness, and stress management. Researchers me…

This completed study interviewed 28 women with a history of bulimia or binge-eating disorder about their pregnancy and postpartum experiences. Researchers aimed to understand how these women cope with body changes and interact with healthcare services. The goal is to improve care…

This study tested whether a single virtual group session could help Spanish-speaking mothers learn about postpartum depression and available resources. Twenty-six mothers of infants under 2 months old participated. The session included a video testimonial, discussion of symptoms,…