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New pill shows promise for severe postpartum depression in phase 3 trial

NCT ID NCT06979544

Completed Symptom relief Sponsor: Lipocine Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an oral drug called LPCN 1154A in 90 women with severe postpartum depression. The goal was to see if it reduces depressive and anxiety symptoms better than a placebo. Participants took the drug or a placebo and were monitored for side effects and mood changes using a standard depression scale.

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Conditions

The condition(s) this trial relates to.

postpartum depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION, POST-PARTUM DEPRESSION, POSTPARTUM PERIPARTUM DEPRESSION POST-NATAL DEPRESSION POSTNATAL DEPRESSION POSTPARTUM DEPRESSION (PPD)

Contacts and locations

Locations

  • Advanced Research Center

    Anahiem, California, 92805, United States

  • Alliance Research Institute

    Canoga Park, California, 91304, United States

  • Atlanta Behavioral Research

    Atlanta, Georgia, 30338, United States

  • Best Clinical Trials

    New Orleans, Louisiana, 70115, United States

  • CenExel Research Center

    Decatur, Georgia, 30030, United States

  • CenExel Research Center

    Savannah, Georgia, 31405, United States

  • Clinical Research Prime

    Idaho Falls, Idaho, 83404, United States

  • Cypress Medical Research Center, LLC

    Kansas City, Kansas, 67226, United States

  • D&H National Research Centers

    Miami, Florida, 33155, United States

  • Gadolin Research

    Beaumont, Texas, 77702, United States

  • Maximos OB/GYN

    League City, Texas, 77573, United States

  • MedOne Clinical Research, LLC

    Miami, Florida, 33145, United States

  • Meridian International Research

    Miami Gardens, Florida, 33014, United States

  • Monroe Biomedical Research

    Monroe, North Carolina, 28112, United States

  • New Dawn Wellness and Medical Center

    Houston, Texas, 77082, United States

  • Oasis Clinical Research

    Las Vegas, Nevada, 89121, United States

  • Populace Research

    Provo, Utah, 84604, United States

  • Suburban Research Associates

    Media, Pennsylvania, 19063, United States

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