Postpartum depression

This study tests whether intensive home-based psychiatric treatment can help children and teens with mental health disorders as an alternative to being in the hospital. Over 3 months, participants receive 3 to 7 home visits per week from a team of doctors, therapists, and other s…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study tests a new way of delivering mental health and addiction services to youth aged 14-17. Instead of standard hospital outpatient care, an integrated team offers rapid access to various services like therapy, peer support, and primary care in a youth-friendly setting. Re…

This study tests whether a special food supplement with added omega-3s and choline can help undernourished pregnant women carry their babies longer and improve their babies' brain development. It also tests a simple talk therapy program to reduce depression during and after pregn…

This study tests a program called Living Healthy for Moms, where doulas provide cognitive behavioral training and heart health coaching to new mothers. The goal is to reduce postpartum depression and lower the risk of heart problems. The trial includes 21 mothers who recently gav…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study tests a psychological empowerment program designed to prevent postpartum depression in pregnant women. 92 first-time mothers in Indonesia will take part in 5 group sessions over 3 weeks, focusing on control, confidence, and coping. Researchers will check if the program…

This study tests a 12-week digital group program called IMAGINE to see if it can prevent depression in pregnant people and new mothers who are at higher risk. About 100 participants will either join the online group or receive standard care. Researchers will check depression and …

This study tests whether virtual prenatal yoga classes can prevent postpartum depression in pregnant women who have a history of depression. About 62 women will be randomly assigned to either take yoga classes or receive standard care. Researchers will track depression symptoms a…

This study planned to give soft infant carriers to Black pregnant parents through a home visiting program, to see if babywearing could help prevent postpartum depression and increase breastfeeding. The researchers believed that babywearing, a practice common in many cultures, cou…

This study tests whether a 4-5 week online program can prevent postpartum depression in expecting parents who have certain risk factors. About 520 parents will be randomly assigned to the online training or usual care. The program includes lessons and exercises to reduce negative…

This pilot study tests whether a brief cognitive behavioral therapy delivered via video conference can help adults with mood disorders who are at high risk for suicide. Forty participants will either receive the video therapy plus usual care, or usual care alone. The study will m…

This study looks at whether an 8-week yoga program during pregnancy can lower the risk of postpartum depression and strengthen the bond between mother and baby. It involves 60 first-time mothers who are 26-28 weeks pregnant. Participants will either take yoga classes or receive s…

This study tests whether an online self-compassion program can help fathers of infants who are feeling anxious or depressed. Forty fathers in Hong Kong will take part in five weekly online sessions. The goal is to see if the program is practical and helpful for improving their me…

This study tests whether using a virtual reality (VR) relaxation session can lower anxiety in people about to receive electroconvulsive therapy (ECT). Twenty adults already receiving ECT for depression will try VR relaxation, breathing exercises, or no extra relaxation. Researche…

This study tests a brief behavioral therapy program delivered via telehealth (STEP-UP) for children and teens aged 8 to 16 with anxiety or depression. Participants are recruited from community health centers and randomly assigned to either STEP-UP or a referral to local mental he…

This study compares a text message-based mental health and substance use screening program (Listening to Women & Pregnant and Postpartum People) to standard in-person screening. Over 10,000 pregnant and postpartum people will participate. The goal is to see if the text-based appr…

This study tests whether virtual reality (VR) therapy can reduce depressive symptoms in pregnant women who are hospitalized for at least three weeks. Participants will either receive VR-based behavioral activation therapy or standard social work consultations. The goal is to see …

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This study looks at whether listening to Surah Al-Inshirah (a chapter from the Quran) in the first two days after a C-section can improve a mother's spiritual well-being, lower depression risk, and strengthen her bond with her newborn. About 172 first-time Muslim mothers who had …

This study tests a group therapy called Awareness, Courage, and Love (ACL) for older adults with psychiatric disorders who feel lonely. The therapy focuses on mindfulness, sharing feelings, and building connections. Researchers want to see if the program is practical and helpful …

This study tests whether a 10-week online group talking therapy (CBT) can help mothers and birthing parents with postpartum depression or anxiety. About 48 participants in Ontario will be randomly assigned to receive the therapy plus usual care, or usual care alone. The goal is t…

This study tests whether taking postbiotics (a dietary supplement) for 8 weeks can reduce depressive symptoms and improve mood in Korean adults aged 19-39 with mild to moderate mood issues. Fifty-two participants will receive either postbiotics or a placebo, and their mood will b…

This study tests whether a 9-week online group talk therapy program, co-led by a public health nurse and a mother who has recovered from postpartum depression, can reduce depression symptoms in new mothers. 170 mothers in Ontario with an infant under 12 months and signs of depres…

This program provides early access to ZULRESSO (brexanolone) for adult women with postpartum depression before the drug is widely available. Eligible women receive a one-time injection under medical supervision. The goal is to help ease severe depression symptoms quickly.

This study tests whether a smartphone app called 'Serene Motherhood' can reduce symptoms of postpartum depression in new mothers who are at high risk. About 79 women in Jordan with elevated depression scores will use the app or receive standard care. The goal is to see if the app…

This Phase 1 study aims to understand how the body processes ketamine after a cesarean delivery, and whether it can help with postpartum depression and pain. Fifty participants will receive a low-dose ketamine infusion, and researchers will measure drug levels and side effects. T…

This study tests a 10-week program called 'Grow to Recovery' for people with mental illness. The program is co-led by a peer (someone who also has a mental illness) and a professional. Researchers want to see if it helps participants feel more hopeful and capable. 138 people are …

This study adapts a 'Health at Every Size' program for pregnant people with a BMI over 30. Ten first-time mothers will attend group sessions on nutrition, movement, and self-advocacy. The goal is to see if the program is acceptable and helpful in reducing weight stigma and improv…

This study looks at whether training pediatricians to assess how mothers and babies interact can help identify early signs of child behavior issues or postpartum depression. Over 3,500 mother-child pairs are involved, with babies seen at their one-month checkup. The goal is to se…

This study tests whether an early assessment of activity limitations by occupational therapists can help people with mental disorders return to work. 150 participants in specialized psychiatric care will either receive the assessment or usual care. The goal is to see if this lead…

This study aimed to develop and test a 12-week mental health program designed specifically for young South Asian women aged 16-24 with mood or anxiety disorders. The program was meant to address cultural and gender needs. However, the study was withdrawn before any participants w…

This study looks at whether an 8-week program of daily brain training exercises, combined with a gentle electrical current applied to the scalp (tDCS), can improve thinking, reduce falls, and help seniors with mental health conditions stay independent. About 270 older adults livi…

This study tests whether a 12-week program that combines brain training, social activities, and exercise is practical and liked by seniors with mental health conditions living in community housing. About 18 participants will try the program in small groups, guided by a support wo…

This study tests whether a culturally tailored mobile health program can improve mental health and pregnancy outcomes in Black pregnant women. Half of the 150 participants will receive the program, which builds communication and self-advocacy skills and provides support. The goal…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…

This study looks at how mood disorders and insomnia interact by monitoring heart and brain activity. Researchers will measure signals like heart rate variability and brain waves in 200 people, including healthy volunteers and those with mood or sleep issues. The goal is to unders…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study looks at how a meditation program called TARA changes brain connections in teens aged 14 to 18 with mild or moderate depression. Researchers will use brain scans to see if meditation strengthens a key brain area and reduces depression symptoms. The goal is to understan…

About 11% of new mothers experience postpartum depression, which can affect their baby's growth and development. This study tests whether treating mothers with blue light therapy improves their infants' development and growth during the first year of life. Researchers will compar…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study tests a method called SAIA-MH to help clinics in Mozambique better diagnose, treat, and follow up with people who have mental health conditions. Researchers will compare clinics using this approach to those that don't, involving about 155 patients. The goal is to see i…

This study tests whether using virtual reality (VR) during a C-section can lower the chances of postpartum depression and anxiety. Researchers will compare 98 pregnant women who use VR during surgery to those who don't, measuring mood and brain chemicals linked to depression. The…

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…

This study was designed to see if combining low-dose ketamine injections with interpersonal therapy could help improve mood in low-income women after a C-section. The researchers planned to enroll 0 participants and the study was withdrawn before it began. No results are availabl…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…