New hope for teen moms: drug targets postpartum depression

NCT ID NCT03665038

Completed Symptom relief Sponsor: Supernus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested the safety of a drug called brexanolone in 28 teenage mothers with postpartum depression. The drug was given as an IV infusion. Researchers monitored side effects and how the drug moved through the body. The goal was to see if it could be a safe treatment option for this age group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: brexanolone (given as an IV infusion)
What this could lead to: If it works, this could provide a treatment option for teenage mothers with postpartum depression.
What could go wrong: This was a small, open-label study with no placebo group, so results are preliminary. Side effects are possible, and it may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

postpartum depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST PARTUM DEPRESSION

Contacts and locations

Locations

Sage Investigational Site

Tempe, Arizona, 85226, United States
Sage Investigational Site

North Little Rock, Arkansas, 72758, United States
Sage Investigational Site

Miramar, Florida, 33029, United States
Sage Investigational Site

Orlando, Florida, 32807, United States
Sage Investigational Site

Pensacola, Florida, 32502, United States
Sage Investigational Site

Pinellas Park, Florida, 33782, United States
Sage Investigational Site

Pompano Beach, Florida, 33060, United States
Sage Investigational Site

Atlanta, Georgia, 30331, United States
Sage Investigational Site

Decatur, Georgia, 30030, United States
Sage Investigational Site

Edgewood, Kentucky, 41017, United States
Sage Investigational Site

Owensboro, Kentucky, 42303, United States
Sage Investigational Site

Flowood, Mississippi, 39232, United States
Sage Investigational Site

Jackson, Mississippi, 39216, United States
Sage Investigational Site

Chapel Hill, North Carolina, 27599, United States
Sage Investigational Site

Middleburg Heights, Ohio, 44130, United States
Sage Investigational Site

Houston, Texas, 77058, United States
Sage Investigational Site

League City, Texas, 77573, United States

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