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Could a 3-Day pill ease severe postpartum depression?

NCT ID NCT06285916

Completed Symptom relief Sponsor: TWi Biotechnology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tested an experimental oral drug called NORA520 in 93 women with severe postpartum depression. Participants took the drug or a placebo for just 3 days. Researchers measured how well it reduced depressive symptoms, checked for side effects, and looked at how much of the drug gets into breastmilk. The goal is to see if NORA520 can offer a fast, short-term treatment option for new mothers struggling with severe depression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
NORA520
What this could lead to
If it works, this could provide a fast-acting, short-course oral treatment for severe postpartum depression, helping new mothers feel better within days.
What could go wrong
This is an early Phase 2 trial with only 93 participants, so results may not apply to everyone. The treatment is only 3 days long, and side effects or lack of effectiveness are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression postpartum depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION, POSTPARTUM POST PARTUM DEPRESSION POST-NATAL DEPRESSION POSTNATAL DEPRESSION POSTPARTUM DEPRESSION

Contacts and locations

Locations

  • Advanced Research Center

    Anaheim, California, 92805, United States

  • Alliance Research Institute

    Canoga Park, California, 91304, United States

  • CenExel Clinical Research

    Decatur, Georgia, 30030, United States

  • CenExel Clinical Research

    Savannah, Georgia, 31405, United States

  • Cenexel Clinical Research

    Sherman Oaks, California, 91403, United States

  • Cenexel Clinical Research

    Torrance, California, 90504, United States

  • Cenexel Clinical Research

    Atlanta, Georgia, 30331, United States

  • Clinical Research Center of Florida

    Pompano Beach, Florida, 33060, United States

  • Combined Research

    Orlando, Florida, 32807, United States

  • GCP Research

    St. Petersburg, Florida, 33607, United States

  • Insight Hospital and Medical Center Chicago

    Chicago, Illinois, 60616, United States

  • Maximos Ob/Gyn

    League City, Texas, 77573, United States

  • MedOne Clinical Research

    Miami, Florida, 33145, United States

  • Meridian International Research, Inc.

    Miami Gardens, Florida, 33014, United States

  • Monroe Biomedical Research

    Monroe, North Carolina, 28112, United States

  • Pillar Clinical Researc

    Richardson, Texas, 75080, United States

  • Pillar Clinical Research

    Bentonville, Arkansas, 72712, United States

  • Zucker Hillside Hospital

    Glen Oaks, New York, 11004, United States

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