A headset for depression in pregnancy — science tests a Drug-Free option

NCT ID NCT05097586

Recruiting now Symptom relief Sponsor: Women's College Hospital Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This trial tests whether a non-invasive brain-stimulation device called transcranial direct current stimulation (tDCS) can reduce symptoms of moderate-to-severe depression in pregnant people. Participants use the device at home for 15 sessions over three weeks, while a comparison group receives a sham (inactive) device. The study aims to see if tDCS offers a safe, medication-free way to manage depression during pregnancy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a gentle brain-stimulation device called transcranial direct current stimulation (tDCS), delivering a low electrical current to the scalp
What this could lead to: If it works, this could offer a drug-free option for treating depression during pregnancy, when medication choices are limited.
What could go wrong: This is a mid-sized trial, and the sham group also receives a workbook, so the added benefit of tDCS may be small. The device is used at home, so correct use and adherence are uncertain.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder postpartum depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSION POSTPARTUM DEPRESSION PREGNANCY

Contacts and locations

Locations

Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Women's College Hospital
RECRUITING

Toronto, Ontario, M5S1B2, Canada

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