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New injection shows promise for postpartum depression

NCT ID NCT02942004

Completed Symptom relief Sponsor: Supernus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental drug called SAGE-547 (brexanolone) given as a 60-hour intravenous infusion to 138 women with severe or moderate postpartum depression. The goal was to see if it could quickly reduce depressive symptoms compared to a placebo. Results showed that the drug significantly improved depression scores within days, offering a potential new option for new mothers struggling with this condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

SAGE-547 (brexanolone) injection

What this could lead to

If successful, this could provide a fast-acting treatment option for women suffering from postpartum depression, reducing symptoms within days.

What could go wrong

This is a completed Phase 3 trial, but results may not apply to all women. Side effects and individual responses vary, and the drug requires intravenous infusion in a medical setting.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

postpartum depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTPARTUM DEPRESSION

Contacts and locations

Locations

  • Sage Investigational Site

    Chandler, Arizona, 85226, United States

  • Sage Investigational Site

    Rogers, Arkansas, 72758, United States

  • Sage Investigational Site

    Lemon Grove, California, 91945, United States

  • Sage Investigational Site

    Orange, California, 92868, United States

  • Sage Investigational Site

    Ventura, California, 93003, United States

  • Sage Investigational Site

    Gainesville, Florida, 32607, United States

  • Sage Investigational Site

    Miami, Florida, 33147, United States

  • Sage Investigational Site

    Miramar, Florida, 33027, United States

  • Sage Investigational Site

    Orlando, Florida, 32807, United States

  • Sage Investigational Site

    Pensacola, Florida, 32502, United States

  • Sage Investigational Site

    Pinellas Park, Florida, 33782, United States

  • Sage Investigational Site

    Atlanta, Georgia, 30331, United States

  • Sage Investigational Site

    Hoffman Estates, Illinois, 60169, United States

  • Sage Investigational Site

    Wichita, Kansas, 67226, United States

  • Sage Investigational Site

    Edgewood, Kentucky, 41017, United States

  • Sage Investigational Site

    Owensboro, Kentucky, 42303, United States

  • Sage Investigational Site

    Boston, Massachusetts, 02114, United States

  • Sage Investigational Site

    Boston, Massachusetts, 02115, United States

  • Sage Investigational Site

    Flowood, Mississippi, 39232, United States

  • Sage Investigational Site

    Marlton, New Jersey, 08053, United States

  • Sage Investigational Site

    Glen Oaks, New York, 11004, United States

  • Sage Investigational Site

    Chapel Hill, North Carolina, 27514, United States

  • Sage Investigational Site

    Charlotte, North Carolina, 28211, United States

  • Sage Investigational Site

    Raleigh, North Carolina, 27612, United States

  • Sage Investigational Site

    Columbus, Ohio, 43210, United States

  • Sage Investigational Site

    Dayton, Ohio, 45417, United States

  • Sage Investigational Site

    Philadelphia, Pennsylvania, 19104, United States

  • Sage Investigational Site

    Houston, Texas, 77030, United States

  • Sage Investigational Site

    Houston, Texas, 77058, United States

  • Sage Investigational Site

    Richardson, Texas, 75080, United States

  • Sage Investigational Site

    San Antonio, Texas, 78229, United States

  • Sage Investigational Site

    Orem, Utah, 84058, United States