Magic mushroom compound tested for hard-to-treat mental health struggles
NCT ID NCT06442423
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be followed for up to 6 weeks, with optional longer follow-up. The goal is to see if psilocybin can reduce symptoms and improve functioning, even in people with multiple conditions who are often excluded from other studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin
What this could lead to
If it works, this could point toward a new treatment option for people with hard-to-treat mood, anxiety, trauma, or addiction symptoms that cause real-life disability.
What could go wrong
This is a very early, small, open-label study with no placebo group, so results may not be reliable. Psilocybin can cause intense psychological effects and is not yet approved for any condition.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Connecticut Mental Health Center - Yale School of Medicine
RECRUITINGNew Haven, Connecticut, 06519, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••