Obsessive-compulsive personality disorder

This study tests a new, non-invasive brain stimulation method for people with OCD. It uses mild electrical currents guided by brain wave recordings to target a key brain region. The goal is to reduce OCD symptoms quickly and safely, with effects lasting up to three months. The tr…

This study is testing whether a noninvasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) can boost the effects of a type of talk therapy (Exposure and Response Prevention) for people with obsessive-compulsive disorder (OCD) that hasn't im…

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 kids will be randomly assigned to one of three delivery methods. The goal is to find out which approach impro…

This trial tests whether a therapy that blends Exposure and Response Prevention (ERP) with Habit Reversal Training (HbRT) can reduce both obsessive-compulsive and tic symptoms in adults with Tourettic OCD — a subtype where OCD and tic disorders overlap. Standard treatments usuall…

This study tests whether a special helmet that delivers focused ultrasound can safely and effectively calm overactive brain circuits in people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Participants receive two sessions of this …

This study tests whether a mild nerve stimulation device (tVNS) can make exposure therapy work better for people with OCD. About 56 adults with moderate to severe OCD will receive either real or fake stimulation during therapy sessions. The goal is to see if the combination reduc…

This study tests whether wearing light therapy glasses for one hour each morning can reduce obsessive-compulsive disorder (OCD) symptoms in young adults (ages 18–35) who go to bed at 1 a.m. or later. Participants wear the glasses daily for five weeks, track their sleep, and compl…

This study tests whether a special kind of talk therapy, called Emotion-Focused Acceptance and Commitment Therapy (ACT), can reduce symptoms of Obsessive-Compulsive Disorder (OCD). About 36 adults with OCD will be randomly assigned to either ACT group therapy or a supportive grou…

This study tests an accelerated form of transcranial magnetic stimulation (TMS) for people with obsessive-compulsive disorder (OCD) who haven't gotten better with standard treatments. Over 7 days, 30 participants will receive 28 sessions of brain stimulation targeting areas linke…

This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…

This study tests a new, faster version of a brain stimulation treatment called TMS for people with depression or OCD. Instead of daily sessions for weeks, participants get 10 hours of TMS each day for just 5 days. The goal is to see if this quick approach can improve symptoms and…

This study tests whether online group cognitive behavioral therapy (CBT) can reduce depression, anxiety, and other mental health symptoms in adults with cystic fibrosis and their caregivers. Participants will attend 13 sessions via Zoom and be compared to those receiving supporti…

This study tests a new, faster version of transcranial magnetic stimulation (TMS) for obsessive-compulsive disorder (OCD). Twenty adults with OCD who haven't improved enough with standard treatments will receive six TMS sessions each day for five days. The goal is to see if this …

This study looks at whether giving exposure therapy for OCD at different times in a woman's menstrual cycle changes how well it works. Researchers will use brain scans to see if hormones affect the brain's fear network and OCD symptoms. The goal is to find the best time in the cy…

This study will carefully examine the physical and mental health of 100 adults admitted to NHS mental health wards. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like bipolar disorder, schizophrenia, depression, and persona…

This study looks back at the treatment records of about 12,000 people with depression, OCD, or anxiety. Researchers will compare how well two treatments—NeuroStar TMS and Esketamine—reduce symptoms. The goal is to learn which approach works better in real-world settings.

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study looks at 50 people with OCD or Tourette syndrome to find clear differences between compulsions and tics. Participants wear a smartwatch and a portable brain-wave recorder at home and in the lab. The goal is to help doctors choose the right treatment by using objective …

This study aims to find brain activity patterns and thinking skills that can predict which people with obsessive-compulsive disorder (OCD) will not respond well to standard treatments. Researchers will use brain scans and cognitive tests in 100 participants with OCD and compare t…