Obsessive-compulsive personality disorder
MONDO:0001158A disorder characterized by an enduring pattern of inflexibility, extreme orderliness, and perfectionism which interfere with efficiency and which may manifest in many different contexts, including work and leisure activities, financial matters, and issues of morality or ethics.
Also known as: OCD, obsessional personality
47 clinical trials for this condition and its sub-types.
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Can continued therapy keep OCD symptoms at bay?
Disease control OngoingThis study offers open/aftercare treatment to adults with obsessive-compulsive disorder (OCD) who have completed an earlier study at Stanford's Rodriguez Lab. Participants receive evidence-based psychotherapy and/or pharmacotherapy from trained professionals. The goal is to see i…
Phase: NA • Sponsor: Stanford University • Aim: Disease control
Last updated Aug 15, 2026 00:00 UTC
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Brain pacemaker trial targets Tough-to-Treat OCD
Disease control OngoingThis study tests a personalized deep brain stimulation (DBS) approach for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Ten adults will first undergo brain mapping to find the best stimulation targets, then receive a DBS dev…
Phase: NA • Sponsor: Andrew Moses Lee, MD, PhD • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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Ancient wisdom meets modern science: new group therapy targets anxiety
Symptom relief OngoingThis study explores whether a new type of group therapy, based on Eastern cultural practices, can help people with anxiety disorders. Researchers will enroll 60 participants aged 15 to 55 to test the therapy's effects on anxiety symptoms. The goal is to see if this approach is bo…
Phase: NA • Sponsor: Beijing HuiLongGuan Hospital • Aim: Symptom relief
Last updated Jul 03, 2026 00:00 UTC
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Could a Parkinson's drug tame OCD?
Symptom relief OngoingThis study tests whether tolcapone, a drug used for Parkinson's disease, can reduce symptoms of obsessive-compulsive disorder (OCD) in adults. About 49 people with moderate to severe OCD will receive either tolcapone or a placebo. The main goal is to see if the drug safely lowers…
Phase: PHASE2 • Sponsor: University of Chicago • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Can rewriting your life story improve mental health? small trial tests new therapy
Symptom relief OngoingThis study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …
Phase: NA • Sponsor: University of Aarhus • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Can online therapy plus In-Person sessions help personality disorders?
Symptom relief OngoingThis study is testing a new type of therapy called Blended Dynamic Interpersonal Therapy (B-DIT) for adults with personality disorders. The therapy mixes face-to-face sessions with online modules over several months. The goal is to see if this approach is acceptable to patients a…
Sponsor: De Viersprong • Aim: Symptom relief
Last updated Jun 26, 2026 15:50 UTC
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Lab-Grown brain cells could unlock personalized OCD treatments
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at 60 people with obsessive-compulsive disorder (OCD) who either respond well to medication, respond to brain stimulation, or don't respond to either. Researchers will take blood samples and turn them into nerve cells in the lab to study how these cells react to …
Phase: NA • Sponsor: ASST Fatebenefratelli Sacco • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Real-World therapy study seeks to unlock secrets of personality disorder treatment
Knowledge-focused OngoingThis study follows 91 adults with personality disorders who are receiving intensive psychodynamic therapy in a real-world clinic. Researchers want to see if the therapy works as well outside of strict research settings and what specific factors lead to improvement. The goal is to…
Sponsor: KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC