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One therapy to tackle two conditions: a trial combines exposure and habit reversal for tourettic OCD

NCT ID NCT07725926

Symptom relief Sponsor: University College London Hospitals Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This trial tests whether a therapy that blends Exposure and Response Prevention (ERP) with Habit Reversal Training (HbRT) can reduce both obsessive-compulsive and tic symptoms in adults with Tourettic OCD — a subtype where OCD and tic disorders overlap. Standard treatments usually target only one condition, but this study asks if tackling both at once works better than either therapy alone. Forty adults with Tourettic OCD will receive 12 weekly sessions of the combined therapy, and their symptom changes will be measured at the end of treatment and during follow-up.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a combination of Exposure and Response Prevention (ERP) and Habit Reversal Training (HbRT), two behavioural therapies
What this could lead to
If the combined therapy works, it could offer a single treatment that addresses both OCD and tic symptoms at once, rather than treating each condition separately.
What could go wrong
This is a small, early-stage trial with only 40 participants, so results may not apply to everyone. Behavioural therapies require active participation and may not work for all individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Feb 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 years or older 2. All genders 3. Confirmation of a primary diagnosis of either: a. Tourettes Disorder / Tourette Syndrome b. Persistent Motor or Vocal Tic Disorder / Chronic Motor or Vocal Tic Disorder c. Provisional Tic Disorder / Transient Motor Tics d. Other Specified Tic Disorder e. Unspecified Tic Disorder f. Obsessive-Compulsive Disorder \[d\] Participants taking psychotropic medication are eligible provided medication type and dose remain stable throughout the intervention period \[e\] Ability to provide sustained informed consent \[f\] A minimum score of 16 on YBOCS \[g\] A minimum score of 5 on the Premonitory Urge for Tics Scale (PUTS) Exclusion Criteria: 1. Substance misuse 2. Current diagnosis of a personality disorder 3. Schizophrenia 4. Bipolar disorder 5. Contraindications to participation in a trial (i.e., active suicidal ideations and/or requirement of an interpreter) 6. Any psychiatric or neurological condition that, in the opinion of the investigators, would interfere with participation or interpretation of study outcomes.

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Conditions

The condition(s) this trial relates to.

chronic tic disorder obsessive-compulsive disorder obsessive-compulsive personality disorder tic disorder Tourette syndrome transient tic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gilles de la Tourette syndrome Obsessive-compulsive disorder Tic disorder, chronic motor or vocal Tic disorder, combined vocal and multiple motor Tic disorders Tourette disease Tourette disorder Tourettes syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University College London Hospitals NHS Foundation Trust

    RECRUITING

    London, London, WC1N 3BG, United Kingdom

  • University College London Queen Square Institute of Neurology

    RECRUITING

    London, London, WC1N 3BG, United Kingdom

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