OBSESSIVE-COMPULSIVE DISORDER

This study tests a precise brain stimulation technique for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with other treatments. Researchers will map brain activity and implant electrodes to deliver targeted electrical pulses, comparing active stimula…

This study tests if deep brain stimulation (DBS) can help people with severe obsessive-compulsive disorder (OCD) that hasn't improved with other treatments. Ten participants will have a device implanted in their brain and then compare active stimulation to a placebo (sham) to see…

This study tests whether using mobile health technology to personalize OCD symptom tracking can improve therapy for children and teens aged 8-17. Researchers will compare personalized cognitive-behavioral therapy (CBT) to standard CBT in 30 participants. The goal is to see if the…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce symptoms in adults with obsessive-compulsive disorder that hasn't improved with standard treatments. Ten participants will receive two 25mg dose…

This study tests whether a non-invasive brain stimulation technique called rTMS, applied to a specific brain area, can reduce obsessive-compulsive symptoms in adults with OCD. Participants must have tried at least two medications without success. The main goal is to see if sympto…

This study tests whether virtual reality (VR) can help people with obsessive-compulsive disorder (OCD) face their fears in a safe, controlled way. About 62 inpatients will be randomly assigned to standard therapy plus VR exposure, VR brain training, or standard therapy alone. The…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe obsessive-compulsive disorder (OCD) who haven't gotten better with standard drugs or therapy. Fifteen adults aged 18 to 65 will receive 15 therapy…

This study tests whether virtual reality (VR) can help people with obsessive-compulsive disorder (OCD) face their fears in a safe, controlled way. Thirty adults with OCD will first wait five weeks, then receive five VR therapy sessions over five weeks. Researchers will measure ch…

This study tests whether a noninvasive brain stimulation technique called rTMS, combined with a specific type of therapy (Exposure and Response Prevention), can reduce symptoms in people with OCD that hasn't responded to prior treatment. About 48 adults in Southern California wil…

This early-stage study is testing whether psilocybin, the active ingredient in magic mushrooms, can safely help people with obsessive-compulsive disorder (OCD). Thirty adults with moderate-to-severe OCD who haven't improved with standard treatments will receive low, medium, or hi…

This study tests whether an online, therapist-guided cognitive-behavior therapy can help children and teens with autism who also have obsessive-compulsive disorder (OCD). The goal is to reduce OCD symptoms and improve daily functioning. About 220 participants will be enrolled, an…

This study tests a short, culturally adapted version of cognitive behaviour therapy (CaCBT) for people with obsessive-compulsive disorder (OCD) in Pakistan. About 166 adults with OCD will receive the therapy, and researchers will measure changes in OCD symptoms, depression, and a…

This study tests a non-invasive brain stimulation technique called accelerated intermittent Theta Burst Stimulation (iTBS) for people with Obsessive-Compulsive Disorder (OCD) who haven't gotten better with standard treatments. Over 7 days, 30 participants will receive 28 sessions…

This study tests whether combining MDMA with cognitive behavioral therapy (CBT) can safely reduce OCD symptoms. It involves 40 adults with OCD who have not responded to standard treatments. Participants will receive either MDMA or a comparison drug during therapy sessions, and th…

This study tests whether a quick, 5-day course of brain stimulation (called accelerated TMS) can reduce OCD symptoms in adults. Twenty participants will receive six sessions per day, targeting a specific brain area linked to OCD. Researchers will check symptom changes and side ef…

This early-stage study tests a drug called RR-HNK (related to ketamine) to see if it safely reduces obsessive-compulsive disorder (OCD) symptoms. About 45 adults with OCD who haven't been helped by standard treatments will receive either the drug or a placebo. The main goal is to…

This study looks at whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants will attend online group sessions and use a WeChat mini-program for guid…

This study looks at whether a child's genes can predict if they will have behavioral side effects from common antidepressants (SSRIs). Researchers will collect saliva samples from 120 children and young adults aged 6-24 with depression, anxiety, or OCD. The goal is to find geneti…

This study is testing whether a carbon dioxide (CO2) breathing challenge can help predict which people with anxiety, OCD, PTSD, or panic disorder will not respond to exposure-based therapy. Researchers will enroll 600 adults aged 18 to 70. The goal is to see if this easy test can…

This study aims to understand how different parts of the brain's prefrontal cortex control behaviors in people with major depression, obsessive-compulsive disorder, generalized anxiety disorder, or schizophrenia. Participants will receive transcranial magnetic stimulation (TMS) a…

This study explores whether a safe, non-invasive technique called caloric vestibular stimulation (using warm or cool water in the ear) can temporarily improve how well people with obsessive-compulsive disorder, body dysmorphic disorder, or illness anxiety disorder recognize their…

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties to test if personalized training reduces daily negative emotions…

This study is collecting information from 4500 people who need brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find out what factors help predict how well someone will recover after surgery. By standardizing how outcomes are …

This study is creating a shared database of children who have had deep brain stimulation (DBS) for conditions like dystonia, epilepsy, or Tourette syndrome. By collecting information from multiple hospitals, researchers hope to learn which children benefit most, which brain targe…

This study aims to understand why some people are more impulsive or compulsive than others by looking at brain structure, chemistry, and genetics. Researchers will enroll up to 1,100 participants aged 6 to 80, including those with conditions like ADHD, OCD, or autism, as well as …

This study follows 1,000 adults with hard-to-treat depression or OCD who are getting advanced treatments like ECT, TMS, or ketamine. Researchers collect brain scans, voice recordings, and other tests before, during, and after treatment. The goal is to find biological markers that…

This study aims to better understand the brain processes behind compulsivity in Obsessive-Compulsive Disorder (OCD). Researchers will use computer models and EEG brain scans to compare 50 adults with OCD and 50 healthy volunteers. The goal is to find more detailed patterns that c…

This study aims to understand why exposure therapy helps some people with OCD but not others. Researchers will track 400 adults with OCD during therapy sessions, measuring things like heart rate and self-reported feelings. The goal is to find out which parts of therapy work best …

This study looks at whether adding a second type of brain stimulation (cortical stimulation) to standard deep brain stimulation (DBS) can better treat severe obsessive-compulsive disorder (OCD). Researchers will record brain signals and test symptom changes in 15 adults with OCD …

This study will analyze data from up to 156,000 people who received NeuroStar TMS for depression, OCD, or anxiety. Researchers want to learn how patient age, symptoms, and treatment settings affect results. The goal is to improve real-world use of TMS, not to test a new treatment…

This study looks at how ketamine works in the brain to quickly reduce symptoms of obsessive-compulsive disorder (OCD). Researchers will measure changes in OCD severity using a standard scale. The study involves 150 adults aged 18-65 with OCD who have not improved with at least on…

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation skills training can help people with mood, anxiety, or related disorders better control their emotions. 240 adults aged 18-55 with high emotional distress will be randomly assig…