Could gut bacteria hold the key to childhood OCD?

NCT ID NCT06754319

Recruiting now Knowledge-focused Sponsor: Shanghai Mental Health Center Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study investigates how the gut-brain axis—the communication network between gut bacteria and the brain—might be involved in pediatric obsessive-compulsive disorder (OCD). Researchers will compare gut microbiome, blood metabolites, brain imaging, and EEG data from children with OCD, those with OCD plus tic disorder, and healthy controls, before and after treatment with SSRIs. The goal is to uncover biological clues that could lead to new treatment targets and better strategies for managing OCD in young people.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Selective serotonin reuptake inhibitors (SSRIs) — a standard class of antidepressants used to treat OCD.
What this could lead to: If successful, this could reveal how the gut-brain axis contributes to pediatric OCD, potentially leading to new biomarkers or treatment targets that improve care for children with this condition.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test whether any new therapy works. The findings may be complex and require further validation before they can influence clinical practice.

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder tic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSESSIVE-COMPULSIVE DISORDER TIC DISORDER

Contacts and locations

Locations

Shanghai Mental Health Center
RECRUITING

Shanghai, Shanghai Municipality, 200030, China

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