Can a wearable headband quiet the Brain's OCD circuitry?

NCT ID NCT07728994

Recruiting now Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial tests whether a wearable headband called ATTN201 can safely reduce obsessive-compulsive disorder (OCD) symptoms. The device delivers low-intensity focused ultrasound to a deep brain region involved in OCD, without surgery. Forty adults with moderate-to-severe OCD will receive either active or sham stimulation over several weeks to see if the treatment eases symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a wearable headband that delivers low-intensity focused ultrasound to the subthalamic nucleus
What this could lead to: If it works, this could offer a non-invasive, drug-free option for people with OCD who do not respond well to standard treatments.
What could go wrong: This is an early-stage trial with only 40 participants, so results may not apply to everyone. The device is still experimental, and its safety and effectiveness are not yet proven.

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSESSIVE-COMPULSIVE DISORDER

Contacts and locations

Locations

Attune Neurosciences
RECRUITING

San Francisco, California, 94107, United States

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