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Brain training targets impulse control to fight OCD and related disorders

NCT ID NCT05377125

Disease control Sponsor: University of Wisconsin, Milwaukee Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This study tests whether a computerized training program designed to improve response inhibition — the ability to stop an automatic action — can reduce symptoms in people with obsessive-compulsive disorder, trichotillomania (hair-pulling), or skin-picking disorder. Participants are randomly assigned to receive either the active training or a placebo version over 8 to 16 sessions. The researchers measure changes in symptom severity and brain activity using MRI scans to see if the training works and how.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
computerized cognitive training
What this could lead to
If effective, this training could offer a new, non-drug treatment option for people with obsessive-compulsive and related disorders.
What could go wrong
This is an early-stage trial with a modest number of participants. The training may not produce lasting symptom improvement, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 118 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2022

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age between 18 and 60 * moderate level of OCRD symptoms (Yale-Brown Obsessive Compulsive Scale total ≥ 16, Massachusetts General Hospital-Hair pulling Scale total ≥ 12, or Skin Picking Scale-Revised total ≥ 7) * a primary diagnosis of OCRD (i.e., OCD, TTM, or SPD) * estimated IQ \> 80 * presence of a RI deficits (SSRT ≥ 215ms). Exclusion Criteria: * Current substance use disorder * Severe ADHD * Lifetime diagnosis of psychotic disorder, bipolar disorder, or schizophrenia * Current psychotherapy * Change in psychotropic medication status within 8 weeks before the study or during the study * Use of stimulant medication * Active suicidal risk * Contraindications for MRI procedures

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Conditions

The condition(s) this trial relates to.

Excoriation Disorder neurotic excoriation obsessive-compulsive disorder trichotillomania

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obsessive-compulsive disorder Skin-picking Tricholemmoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UWM Anxiety Disorders Laboratory

    RECRUITING

    Milwaukee, Wisconsin, 53211, United States

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