Brain zaps for stubborn OCD: new hope for Therapy-Resistant patients

NCT ID NCT05331937

Recruiting now Symptom relief Sponsor: Amsterdam UMC, location VUmc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a non-invasive brain stimulation technique called TMS for adults with obsessive-compulsive disorder (OCD) who did not improve enough with standard exposure therapy. 250 participants will receive either real or sham TMS combined with therapy for 5-7 weeks. The goal is to see if TMS can reduce OCD symptoms and improve quality of life.

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

1 HZ REAL RTMS TO THE PRE-SMA 1 HZ SHAM RTMS TO THE PRE-SMA

Contacts and locations

Locations

Amsterdam UMC, location VU Medical Center
RECRUITING

Amsterdam, North Holland, 1081 HZ, Netherlands
GGZ inGeest
RECRUITING

Amsterdam, Netherlands
Maastricht UMC+
NOT_YET_RECRUITING

Maastricht, Netherlands
Mondriaan
NOT_YET_RECRUITING

Maastricht, Netherlands
Neurocare
NOT_YET_RECRUITING

Eindhoven, Netherlands
Neurocare
NOT_YET_RECRUITING

Groningen, Netherlands
ProPersona
NOT_YET_RECRUITING

Nijmegen, Netherlands
Radboudumc
NOT_YET_RECRUITING

Nijmegen, Netherlands

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