Amsterdam Umc, Location Vumc

This study looks at whether using a temporary mechanical heart pump during high-risk angioplasty (a procedure to open blocked heart arteries) improves safety for people with weak hearts. About 98 adults with severe coronary artery disease and reduced heart function will be enroll…

This study tests a new treatment for women with recurrent breast cancer who had previous breast-conserving therapy. It uses a single, targeted dose of radiation before repeat surgery to shrink the tumor and possibly reduce side effects and improve cosmetic results. The trial will…

This study tests a new approach for people with pancreatic cancer that can be surgically removed. Before surgery, patients receive a combination of chemotherapy, immunotherapy, and targeted radiation. After surgery, they continue with chemotherapy and immunotherapy. The goal is t…

This study tests a drug called sotatercept in 20 adults with pulmonary arterial hypertension (PAH), a disease that strains the right side of the heart. Unlike standard treatments that only widen blood vessels, sotatercept targets the root cause by helping reverse blood vessel thi…

This study tests a non-invasive brain stimulation technique called TMS for adults with obsessive-compulsive disorder (OCD) who did not improve with standard exposure therapy. 250 participants will receive either real or sham TMS combined with therapy for 5-7 weeks. The goal is to…

This study tests a new exercise program called functional power training (MegaPower) for children with cerebral palsy who can walk. The goal is to see if it helps them reach their personal activity goals, like keeping up with friends. About 66 children aged 4 to 12 will either do…

This study tests a device called Cue2Walk that automatically detects when people with Parkinson's disease freeze up while walking and provides rhythmic cues to help them keep moving. Researchers will compare the device to usual care in 84 participants to see if it improves qualit…

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for long COVID symptoms like severe fatigue and trouble concentrating. Researchers will give 66 adults either real or fake rTMS sessions over six weeks to see if it improves fatigue and thinki…

This study is looking for early warning signs that lung scarring (fibrosis) is getting worse in people with various types of interstitial lung disease. Researchers will follow 450 adults over time, using blood tests, breathing tests, CT scans, and breath analysis to find markers …

This study looks at whether teenagers living in disadvantaged urban areas can work with researchers and local leaders to create changes that make it easier to be active, sleep well, and spend less time on screens. About 1,000 teens from Denmark, the Netherlands, Nigeria, and Sout…

This study follows 500 breast cancer patients whose cancer has returned in the same area. They will receive radiation again, with or without heat therapy (hyperthermia). The goal is to compare side effects, quality of life, and survival over five years to help doctors and patient…