One-Shot radiation before second breast surgery: a new hope for recurrence?
NCT ID NCT06640881
First seen Jun 24, 2026 · Last updated Jul 17, 2026 · Updated 3 times
Summary
This study tests whether a single, high dose of radiation given before repeat breast-conserving surgery is safe and effective for women whose breast cancer has returned after previous treatment. The trial will enroll 25 women aged 50 or older with small, low-risk tumors. The goal is to reduce side effects and improve cosmetic results compared to standard post-surgery radiation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- single-dose partial breast irradiation (radiation therapy)
- What this could lead to
- If successful, this approach could offer a less toxic, more cosmetic-friendly option for women with recurrent breast cancer, potentially reducing the need for mastectomy.
- What could go wrong
- This is a small, early-phase trial with only 25 participants, so results may not apply to all patients. The main risk is radiation-related side effects, and it is not yet known if this approach controls cancer as well as standard treatments.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Amsterdam UMC / VU Medical Centre
RECRUITINGAmsterdam, Netherlands
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