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Could a gentler chemo work for older breast cancer patients?

NCT ID NCT01463072

Ongoing Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study looks at how well older patients (65 and up) with advanced or metastatic breast cancer tolerate a chemotherapy drug called Abraxane. The goal is to see what side effects occur and whether the drug can control tumor growth. Participants receive Abraxane intravenously, and researchers track side effects, dose adjustments, and tumor response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Abraxane (nab-paclitaxel)
What this could lead to
If successful, this could show that Abraxane is a well-tolerated chemotherapy option for older adults with advanced breast cancer, potentially improving quality of life during treatment.
What could go wrong
This is a small Phase 2 trial focused on side effects, not a large efficacy study. The drug may still cause significant toxicity, and results may not apply to all older patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED BREAST CARCINOMA METASTATIC BREAST CARCINOMA RECURRENT BREAST CARCINOMA STAGE III BREAST CANCER AJCC V7 STAGE IIIA BREAST CANCER AJCC V7 STAGE IIIB BREAST CANCER AJCC V7 STAGE IIIC BREAST CANCER AJCC V7 STAGE IV BREAST CANCER AJCC V6 AND V7

Contacts and locations

Locations

  • City of Hope Antelope Valley

    Lancaster, California, 93534, United States

  • City of Hope South Pasadena

    South Pasadena, California, 91030, United States

  • City of Hope medical

    Duarte, California, 91010, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

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