STAGE IIIA BREAST CANCER AJCC V7

This study tests two hormone therapies, tamoxifen and a newer drug called z-endoxifen, in postmenopausal women with a type of advanced breast cancer (ER+/HER2-). The goal is to see which one better delays cancer growth. About 81 women who have already tried an aromatase inhibitor…

This early-phase trial tests the safety and best doses of two drugs (bevacizumab and temsirolimus) given alone or with other medicines (valproic acid or cetuximab) in people with advanced cancer or certain non-cancerous diseases that are hard to treat. The goal is to find the hig…

This study tests the drug pembrolizumab in 21 adults with advanced solid tumors that have specific gene mutations (BRCA1, BRCA2, POLE, or POLD1). The goal is to see if the drug can shrink or control the cancer. Pembrolizumab is a type of immunotherapy that helps the immune system…

This study tests a combination of two drugs, cediranib and olaparib, in people with advanced or inoperable solid tumors, including certain breast, lung, and pancreatic cancers. The goal is to see if the combo can shrink tumors or slow their growth by blocking enzymes that cancer …

This study looks at whether an integrative oncology program—including diet advice, physical activity, stress management, social support, and reducing exposure to environmental toxins—can improve outcomes for women with stage II or III breast cancer undergoing radiation therapy. A…

This study compares a 3-week course of radiation to the standard 5-week course for breast cancer patients who also need radiation to nearby lymph nodes. The goal is to see if the shorter treatment reduces arm swelling (lymphedema) while keeping the risk of cancer returning low. A…

This study tests if a special type of acupuncture (electroacupuncture) can reduce chronic pain in women who have finished treatment for early-stage breast cancer. About 111 women with persistent pain for at least 3 months after surgery will receive either real acupuncture, a sham…