Could a skin gel help fight breast cancer? early trial tests endoxifen
NCT ID NCT03317405
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing a gel form of the drug endoxifen, applied to the skin, in 32 women scheduled for breast surgery. The goal is to see if the gel is safe and how much of the drug gets into breast tissue and blood. If successful, it might offer a gentler way to treat or prevent breast cancer in the future.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- endoxifen hydrochloride gel
- What this could lead to
- If it works, this could lead to a topical treatment that lowers breast cancer risk or helps manage early-stage disease without the side effects of pills.
- What could go wrong
- This is a very early (Phase 1) trial with only 32 participants, so it primarily checks safety and dosing. It may not show any benefit against cancer, and skin irritation at the application site is a possible risk.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
-
Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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