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New drug combo shows promise in Hard-to-Treat cancers

NCT ID NCT02498613

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a combination of two drugs, cediranib and olaparib, in people with advanced solid tumors that have spread or cannot be removed by surgery. The cancers include certain types of breast, lung, and pancreatic cancer. The goal is to see if the combination can shrink tumors or slow their growth by blocking enzymes that cancer cells need to grow and by cutting off the tumor's blood supply.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm cancer exocrine pancreatic carcinoma invasive breast carcinoma malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic adenocarcinoma pancreatic ductal adenocarcinoma small cell lung carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED MALIGNANT SOLID NEOPLASM METASTATIC LUNG NON-SMALL CELL CARCINOMA METASTATIC LUNG SMALL CELL CARCINOMA METASTATIC PANCREATIC ADENOCARCINOMA METASTATIC TRIPLE-NEGATIVE BREAST CARCINOMA PANCREATIC DUCTAL ADENOCARCINOMA STAGE III BREAST CANCER AJCC V7 STAGE III LUNG NON-SMALL CELL CANCER AJCC V7 STAGE III LUNG SMALL CELL CARCINOMA AJCC V7 STAGE III PANCREATIC CANCER AJCC V6 AND V7 STAGE IIIA BREAST CANCER AJCC V7 STAGE IIIA LUNG NON-SMALL CELL CANCER AJCC V7 STAGE IIIA LUNG SMALL CELL CARCINOMA AJCC V7 STAGE IIIB BREAST CANCER AJCC V7 STAGE IIIB LUNG NON-SMALL CELL CANCER AJCC V7 STAGE IIIB LUNG SMALL CELL CARCINOMA AJCC V7 STAGE IIIC BREAST CANCER AJCC V7 STAGE IV BREAST CANCER AJCC V6 AND V7 STAGE IV LUNG NON-SMALL CELL CANCER AJCC V7 STAGE IV LUNG SMALL CELL CARCINOMA AJCC V7 STAGE IV PANCREATIC CANCER AJCC V6 AND V7 TRIPLE-NEGATIVE BREAST CARCINOMA UNRESECTABLE LUNG SMALL CELL CARCINOMA UNRESECTABLE PANCREATIC ADENOCARCINOMA UNRESECTABLE PANCREATIC CARCINOMA UNRESECTABLE TRIPLE-NEGATIVE BREAST CARCINOMA

Contacts and locations

Locations

  • BCCA-Vancouver Cancer Centre

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Moffitt Cancer Center-International Plaza

    Tampa, Florida, 33607, United States

  • Smilow Cancer Center/Yale-New Haven Hospital

    New Haven, Connecticut, 06510, United States

  • UC San Diego Medical Center - Hillcrest

    San Diego, California, 92103, United States

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

  • UCSF Medical Center-Mount Zion

    San Francisco, California, 94115, United States

  • UT MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • University Health Network-Princess Margaret Hospital

    Toronto, Ontario, M5G 2M9, Canada

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia, 23298, United States

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

  • Wayne State University/Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Weisberg Cancer Treatment Center

    Farmington Hills, Michigan, 48334, United States

  • Yale University

    New Haven, Connecticut, 06520, United States

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