ADVANCED MALIGNANT SOLID NEOPLASM

This early-phase trial is testing two experimental drugs, peposertib and tuvusertib, together in people with advanced solid tumors that have spread or cannot be removed. The main goal is to find the safest dose and understand side effects. About 66 adults with specific genetic ch…

This early-stage trial tests CBX-12, a drug that damages cancer cell DNA to kill them, in about 35 adults with advanced or metastatic solid tumors that have worsened after at least one prior treatment. The main goal is to see how the drug affects DNA repair in tumors. This is not…

This early-phase study tests the safety and best dose of TAK-243, a drug that targets a protein cancer cells need to grow. About 95 adults with advanced solid tumors or lymphoma that hasn't responded to standard treatments will take part. The goal is to find side effects and the …

This study tests two experimental drugs, ZEN003694 and entinostat, in people with advanced solid tumors that have stopped responding to standard treatments. The goal is to find the safest dose and see if the combination can shrink tumors. The trial includes up to 49 participants,…

This early-phase study tests a new drug called RSC-1255, alone or with hydroxychloroquine, in people with advanced solid tumors (like lung, colon, pancreatic cancer, or glioblastoma) that have stopped responding to standard treatments. The goal is to find a safe dose and see if t…

This early-stage study tests a new combination of two drugs (trifluridine/tipiracil and talazoparib) in people with advanced colorectal or gastroesophageal cancers that have spread. The main goals are to find the safest dose and understand side effects. About 45 participants will…

This study tests a combination of two drugs, temozolomide and M1774, in adults with advanced solid tumors that have spread. The goal is to find the safest dose and see if the combo can shrink or slow tumor growth better than temozolomide alone. About 58 participants will take par…

This study tests whether giving siltuximab alongside restarting immunotherapy can prevent severe immune-related side effects in 40 adults with advanced cancer who previously had such reactions. Participants will receive siltuximab infusions to calm the immune system while resumin…

This study tests a new drug called NBTXR3, which makes cancer cells more sensitive to radiation, combined with standard radiation and immunotherapy (anti-PD-1/L-1) for people with advanced solid tumors that have spread to the lungs or liver. The goal is to see if this combination…

This study tests whether three targeted cancer drugs (antibody-drug conjugates) can shrink advanced solid tumors that have spread. Patients' tumors are screened for specific proteins (Trop-2, nectin-4, or HER2), and they receive the matching drug. The goal is to see if this perso…

This study tests whether combining three drugs—axatilimab, retifanlimab, and paclitaxel—is safe and works against advanced or metastatic solid tumors. About 38 adults with tumors that have spread will receive the combination. The goal is to find the best dose and see if the treat…

This early-stage study tests a new chemotherapy drug, TR-002, in about 52 people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose and check for side effects. The study also looks at whether the drug can shr…

This early-phase study tests a new drug called IACS-6274, given alone or with other medicines, in people with advanced solid tumors (like certain melanomas, ovarian, and uterine cancers). The main goal is to find the safest dose and understand side effects. About 54 adults will t…

This study tests whether combining two targeted drugs (ZEN003694 and talazoparib) can shrink tumors in people with advanced solid cancers that have spread or cannot be removed. The trial enrolls 88 adults whose cancer no longer responds to standard treatments. Researchers will al…

This early-phase trial tests the drug talazoparib combined with one of three other drugs (palbociclib, axitinib, or crizotinib) in people with advanced or metastatic solid tumors. The goal is to find the safest dose and see if the combinations help control tumor growth. About 111…

This early-phase trial tests a new drug called AU409 in people with advanced liver cancer or other cancers that have spread to the liver. The main goals are to find the safest dose and see what side effects occur. About 36 adults whose cancer has not responded to standard treatme…

This study tests a phone-based coaching program called Talking About Cancer (TAC) to help people with advanced cancer and their support person have important conversations about future medical care. The program, delivered by a social worker, aims to reduce distress and help patie…

This study looks at whether getting immunotherapy in the morning or afternoon changes how well it fights advanced or metastatic solid tumors. Researchers believe the body's internal clock (circadian rhythm) might affect immune response. About 160 adults with certain cancers like …

This study tests if olanzapine, a drug that affects brain chemicals, can help cancer patients who have lost their appetite and weight. The trial includes 66 adults with advanced lung, stomach, or colorectal cancers who are not being treated with a goal to cure. Participants will …

This study compares giving cancer treatment at home versus in a clinic for people with advanced cancers. The goal is to see if home treatment reduces stress, financial burden, and improves the overall experience. About 220 participants will be randomly assigned to receive their t…

This study tests whether a plant-based, low-calorie diet that mimics fasting can reduce common side effects of immunotherapy, such as rash, diarrhea, and fatigue. Ten adults with advanced cancer will follow the diet while receiving treatment. The goal is to improve their quality …

This study screens up to 2,900 people with advanced solid tumors to see if their cancer's genetic makeup can guide them to a targeted combination therapy. Participants must have tried at least one standard treatment. The goal is to learn how well this matching process works and t…

This study looks at how a video-based mentoring program called Project ECHO helps doctors in underserved areas of Kenya, Nigeria, Ghana, South Africa, India, and Ethiopia provide better palliative care to advanced cancer patients. Researchers will track changes in patients' quali…

This study looks at whether a video and a special doctor's visit can help young adults (ages 18-39) with advanced solid tumors or high-grade brain tumors start planning their future medical care early. The goal is to see if these tools are helpful and easy to use. About 50 people…