ADVANCED MALIGNANT SOLID NEOPLASM

This study tests a combination of two drugs, temozolomide and M1774, in people with advanced or metastatic solid tumors. The goal is to find the best dose and see if the combo can shrink tumors or keep them from growing longer than temozolomide alone. About 42 adults with certain…

This early-stage study tests a new drug called TAK-243 in about 95 adults with advanced solid tumors or lymphoma that has not responded to standard treatments. The main goal is to find the safest dose and understand side effects. TAK-243 works by blocking a protein that cancer ce…

This early-phase study tests an experimental drug called RSC-1255, given alone or with hydroxychloroquine, in people with advanced solid tumors (like lung, colon, pancreatic, or brain cancer) that have stopped responding to standard treatments. The main goals are to find a safe d…

This early-phase study tests a new chemotherapy drug called TR-002 in about 52 adults with advanced solid tumors, including pancreatic cancer, that have not responded to standard treatments. The main goals are to find the safest dose and to understand side effects. Researchers wi…

This study tests whether giving siltuximab alongside restarting immunotherapy can prevent severe immune-related side effects in people with advanced cancer. About 40 adults who previously had serious side effects from immunotherapy will receive siltuximab to calm the immune syste…

This early-stage trial tests a new drug called AU409 in about 36 adults with advanced liver cancers or solid tumors that have spread to the liver. The main goals are to find the safest dose and check for side effects. Researchers also want to see if the drug can shrink tumors or …

This early-phase study tests a new drug called IACS-6274, given alone or with other medicines, in people with advanced solid tumors (like certain melanomas, ovarian, or uterine cancers). The main goal is to find the safest dose and understand side effects. About 54 adults will ta…

This early-phase study tests CBX-12 in about 35 adults with advanced solid tumors that have spread and stopped responding to prior treatments. CBX-12 works by entering cancer cells and damaging their DNA, which can kill the cells. Researchers will measure how well the drug trigge…

This study tests whether three antibody-drug conjugates (ADCs) can shrink advanced solid tumors that have high levels of specific proteins (Trop-2, nectin-4, or HER2). About 500 adults with cancers that have spread and no longer respond to standard treatments will receive a drug …

This early-phase trial tests two experimental drugs, peposertib and tuvusertib, together in adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find the safest dose and understand side effects. About 66 participants will take part. This …

This study tests a new approach for people with advanced solid tumors that have spread to the lungs or liver. It combines a drug called NBTXR3, which makes cancer cells more sensitive to radiation, with radiation therapy and an immunotherapy drug (anti-PD-1/L-1) that helps the im…

This study tests whether a combination of two drugs (ZEN003694 and talazoparib) can shrink tumors in people with advanced solid cancers that have stopped responding to standard treatments. About 88 adults will take part. Researchers will also look at participants' genes to see if…

This early-stage study tests a new combination of two drugs (talazoparib and trifluridine/tipiracil) in people with advanced colorectal or gastroesophageal cancers that have spread. The main goals are to find the safest dose and understand side effects. Up to 45 participants will…

This study tests whether combining three drugs—axatilimab, retifanlimab, and paclitaxel—is safe and effective for people with advanced or metastatic solid tumors. Axatilimab and retifanlimab are antibodies that help the immune system fight cancer, while paclitaxel stops cancer ce…

This study tests two experimental drugs, ZEN003694 and entinostat, in people with advanced solid tumors that have stopped responding to standard treatments, including pancreatic cancer. The goal is to find the safest dose and see if the combination can shrink tumors. About 49 par…

This early-stage trial tests a drug called talazoparib combined with one of three other drugs (palbociclib, axitinib, or crizotinib) in people with advanced solid tumors that have spread. The goal is to find the safest dose and see if the combinations can help control the cancer.…

This pilot study tests whether a low-calorie, plant-based diet that mimics fasting can reduce common side effects like rash, diarrhea, and fatigue in cancer patients receiving immunotherapy. Ten adults with advanced cancer will follow the diet while researchers track symptoms and…

This study looks at whether getting immunotherapy in the morning or afternoon makes it work better for people with advanced or spreading solid tumors. The body's internal clock (circadian rhythm) may affect how the immune system responds. Researchers will compare progression-free…

This study compares giving cancer treatment at home versus in a clinic for people with advanced cancers. The goal is to see if home treatment reduces stress, financial burden, and improves overall experience. About 220 participants will be randomly assigned to receive their thera…

This study tests whether a telephone coaching program called Talking About Cancer (TAC) helps people with advanced cancer and their support person engage in advance care planning, such as having end-of-life conversations and completing advance directives. About 80 patients and th…

This study tests whether olanzapine, a drug that affects brain chemicals, can help cancer patients who are losing weight and appetite. About 66 adults with advanced lung, stomach, or colorectal cancer will receive either olanzapine or a placebo. The goal is to see if the drug hel…

This study screens up to 2,900 people with advanced or hard-to-treat solid tumors to find genetic changes in their cancer cells. Based on those results, patients may be matched to a treatment trial that uses a combination of drugs targeting their specific mutations. The goal is t…

This study looks at whether a remote training program called Project ECHO can improve the quality of palliative care for advanced cancer patients and their caregivers in underserved areas of Kenya, Nigeria, Ghana, South Africa, India, and Ethiopia. About 312 patients and their ca…

This study looks at whether educational tools—like a video and a special appointment—can help teens and young adults (ages 18-39) with advanced solid tumors or high-grade brain tumors start planning their medical care early. About 50 people will take part. The goal is to see if t…