ADVANCED MALIGNANT SOLID NEOPLASM

This early-phase trial tested a combination of two drugs, sapanisertib and ziv-aflibercept, in 83 adults with advanced solid tumors that had spread or could not be removed by surgery. The main goal was to find the safest dose and identify side effects. The approach aims to slow t…

This early-stage trial tested a new drug (AZD8186) combined with chemotherapy (docetaxel) in 23 people with advanced solid tumors that have certain gene mutations (PTEN or PIK3CB). The main goals were to find the best dose and check for side effects. The study was completed, but …

This early-stage trial tested two drugs, cabozantinib and pamiparib, in 44 people with advanced solid tumors that had stopped responding to standard treatments. The goal was to find the safest dose and see how well the drugs worked together to block cancer cell growth. The study …

This early-stage trial tested a new drug called ALRN-6924 combined with the chemotherapy paclitaxel in 28 adults with advanced solid tumors that had spread or couldn't be removed by surgery, including a type of breast cancer. The main goal was to find the safest dose and check fo…

This study tested a drug called samotolisib in 18 children and teens whose cancers had spread, come back, or stopped responding to treatment. The drug works by blocking certain enzymes that cancer cells need to grow. The goal was to see if the drug could shrink or stop the cancer…

This study tested an oral drug called infigratinib in 17 adults with advanced or metastatic solid tumors that have specific FGFR gene mutations. The goal was to see if the drug could shrink or control the cancer by blocking overactive FGFR proteins. While not a cure, the treatmen…

This study tested the drug palbociclib in 23 children and young adults (ages 1-21) whose cancers had come back or stopped responding to treatment. The drug works by blocking certain proteins that help cancer cells grow. The goal was to see if it could shrink tumors or slow the di…

This study tested a drug called tazemetostat in 20 children whose cancers had come back or weren't responding to treatment. The children had specific gene changes (EZH2 or SWI/SNF) in their tumors. The goal was to see if the drug could shrink or control the cancer. This is a dise…

This study tested a combination of three immunotherapy drugs (ipilimumab, nivolumab, and BMS-986156) with or without precise radiation therapy in 51 adults with advanced solid tumors that had spread to the lung, chest, or liver. The goal was to find the safest dose of BMS-986156 …