New drug combo shows promise for Hard-to-Treat cancers
NCT ID NCT03218826
First seen Oct 31, 2025 · Last updated Jun 11, 2026 · Updated 31 times
Summary
This early-phase study tested a new drug (AZD8186) combined with chemotherapy (docetaxel) in 23 people with advanced solid tumors that have certain gene mutations (PTEN or PIK3CB). The main goal was to find the safest dose and understand side effects. The study is complete, and results help guide future research for these hard-to-treat cancers.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
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National Cancer Institute Developmental Therapeutics Clinic
Bethesda, Maryland, 20892, United States
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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UCHealth University of Colorado Hospital
Aurora, Colorado, 80045, United States
Conditions
Explore the condition pages connected to this study.