STAGE III PROSTATE CANCER AJCC V8

This study tests whether high-dose vitamin D can prevent bone loss caused by hormone therapy (ADT) in older men with prostate cancer. About 240 men aged 50+ who are starting or recently started ADT will take either high-dose vitamin D or a placebo for a year. Researchers will mea…

This study looks at whether testosterone replacement therapy (TRT) is safe and beneficial for men with low-risk prostate cancer who are on active surveillance (watchful waiting). Many men with low testosterone avoid TRT due to fears it might worsen their cancer, but this trial ai…

This study compares a new, shorter radiation treatment (5 sessions over 2 weeks) to the standard longer treatment (20-45 sessions over 4-9 weeks) for men with high-risk prostate cancer. The goal is to see if the shorter approach is just as effective at preventing the cancer from …

This study compares two hormone therapy combinations (leuprolide or relugolix plus abiraterone acetate) in men with advanced prostate cancer who are also getting radiation. The goal is to see which combination causes less harm to the heart, since these treatments can raise blood …

This study tests whether a precise, short-course radiation therapy (SBRT) works as well as a slightly longer radiation approach (hypofractionated radiotherapy) for prostate cancer that has come back or spread to a few spots after surgery. About 118 men with low PSA levels will be…

This study tests whether adding a drug called apalutamide to standard hormone therapy and radiation can keep prostate cancer from spreading in people whose cancer was found in lymph nodes after prostate removal surgery. About 586 participants will be randomly assigned to get eith…

This study is for men with high-risk prostate cancer that hasn't spread far. It tests whether adding the drug niraparib to standard hormone therapy after radiation can keep the cancer from coming back longer. About 200 participants will receive either hormone therapy alone or hor…

This study tests the drug talazoparib in adults with advanced solid tumors (like breast, prostate, ovarian, pancreatic, or stomach cancer) that have certain gene changes affecting DNA repair. The drug blocks a protein called PARP, which cancer cells need to fix their DNA, potenti…

This study tests a precise type of radiation called proton therapy for men with high-risk prostate cancer that has spread to lymph nodes. The goal is to see if targeting the tumor and nearby lymph nodes causes fewer bowel and bladder side effects than standard radiation. About 30…

This study tests whether a new type of PET/MRI scan can accurately detect if prostate cancer has spread to nearby lymph nodes. About 50 men with high-risk prostate cancer who are scheduled for prostate removal surgery will receive this scan beforehand. The goal is to see if the s…

This study tests whether taking a short course of hormone therapy (relugolix) before a PSMA PET/CT scan can make the scan better at finding prostate cancer that has spread. About 30 men with high-risk prostate cancer will get the hormone drug for 5, 10, or 15 days before their sc…

This study looks at whether giving cancer therapy at home is safer and more satisfying for Black men with advanced prostate cancer compared to receiving it in a clinic. About 38 participants will try both settings and rate their experience. The goal is to reduce stress and improv…

This study compares two ways of giving stereotactic body radiation therapy (SBRT) for prostate cancer that hasn't spread. In standard SBRT, the radiation plan is fixed. In the new approach, doctors use daily MRI or CT scans to adjust the plan to match the patient's anatomy that d…

This study tests whether a newer, shorter radiation method (adaptive therapy, 2 treatments) causes fewer side effects and maintains quality of life compared to the standard 5-treatment approach for men with localized prostate cancer. About 144 participants will be randomly assign…

This study compares the side effects of two standard treatments for advanced prostate cancer: abiraterone plus prednisone versus darolutamide alone. About 75 men with prostate cancer that has spread will be enrolled. The goal is to see which treatment causes fewer severe side eff…

This study tests a new way to deliver radiation for prostate cancer that hasn't spread. By using real-time tracking to adjust the beam as the prostate moves, doctors hope to reduce urinary and bowel side effects. The study will enroll 80 men with early-stage prostate cancer to se…

This study tests whether a supervised golf exercise program can improve physical function, mental health, and quality of life in prostate cancer survivors who are on hormone therapy. Twenty men aged 55-85 with little or no golf experience will participate. The program includes wa…

This study tests whether using bright white light therapy glasses can reduce fatigue and improve mood in men with advanced prostate cancer who are receiving hormone therapy (ADT) combined with other treatments. About 210 men will either start light therapy right away or wait a fe…

This study tests a special tissue wrap placed on the nerves during prostate removal surgery for men with localized prostate cancer. The wrap aims to reduce common side effects like erectile dysfunction and urine leakage. About 25 men will take part to see if the wrap is safe and …

This study looks at whether having a trained peer navigator—someone who guides patients through the process—helps African American men with prostate cancer that has spread understand and complete genetic testing. Genetic testing is important for treatment decisions, but many Afri…