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Double-Dose precision: new combo radiation aims to shrink prostate tumors faster

NCT ID NCT04945642

Recruiting now Disease control Sponsor: Jonsson Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial tests a combination of two advanced radiation techniques for men with intermediate- to high-risk prostate cancer that has not spread beyond the prostate. One technique, high-dose rate brachytherapy, places radioactive material directly into the tumor. The other, stereotactic body radiotherapy, delivers highly focused radiation from outside the body. The goal is to see if this combination can control the cancer while reducing side effects and treatment time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
High-dose rate brachytherapy and stereotactic body radiotherapy
What this could lead to
If successful, this approach could offer a shorter, more precise radiation treatment for prostate cancer with fewer side effects.
What could go wrong
This is a phase 2 trial with a small number of participants, so results may not apply to all patients. Radiation can still cause urinary or bowel side effects.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma prostate adenocarcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE ADENOCARCINOMA STAGE IIB PROSTATE CANCER AMERICAN JOINT COMMITTEE ON CANCER (AJCC) V8 STAGE IIC PROSTATE CANCER AJCC V8 STAGE III PROSTATE CANCER AJCC V8 STAGE IIIA PROSTATE CANCER AJCC V8 STAGE IIIB PROSTATE CANCER AJCC V8 STAGE IIIC PROSTATE CANCER AJCC V8 STAGE IVA PROSTATE CANCER AJCC V8

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of California at Los Angeles / Jonsson Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90095, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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