STAGE IVA PROSTATE CANCER AJCC V8

This study aims to find out which of two standard hormone therapy combinations is safer for the heart when treating advanced prostate cancer. It will enroll 72 men who are about to start radiation therapy and need hormone treatment. Researchers will use special heart scans and bl…

This study is testing if adding a drug called niraparib to standard hormone therapy after radiation treatment works better at controlling high-risk prostate cancer that is still in the prostate area or nearby lymph nodes. It will enroll about 200 men. The goal is to see if this c…

This large study is testing whether adding surgery to remove the prostate or radiation therapy to standard drug treatments helps men with prostate cancer that has spread to other parts of the body live longer. It will enroll over 1,200 men who have already started standard hormon…

This study is for men whose prostate cancer has spread to nearby lymph nodes after surgery. It tests if adding a drug called apalutamide to the usual hormone and radiation therapy can better control the cancer and prevent it from spreading further. The goal is to see if this stro…

This study is testing whether taking a high weekly dose of vitamin D can help protect bone strength in older men with prostate cancer who are receiving hormone therapy. Hormone therapy can weaken bones, increasing the risk of fractures and falls. Researchers will compare the bone…

This study is testing a two-step treatment for advanced prostate cancer that has spread and stopped responding to standard hormone therapies and chemotherapy. First, patients take a pill (abemaciclib) for two weeks, aiming to make cancer cells more visible. Then, they receive a t…

This study is testing whether adding a new targeted drug called talazoparib to standard hormone-blocking treatments can better control advanced prostate cancer that has spread. It aims to see if this combination helps stop cancer growth for longer by preventing cancer cells from …

This large trial is comparing two different radiation schedules for men with high-risk prostate cancer. It will test if a much shorter, more intense treatment (5 sessions over 2 weeks) is as effective at preventing the cancer from spreading as the standard, longer course (20-45 s…

This study is testing a new type of imaging scan to see if it can accurately tell whether prostate cancer has spread to nearby lymph nodes. If successful, this scan could help doctors decide which patients truly need to have their lymph nodes removed during prostate cancer surger…

This study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…

This study aims to learn why some advanced prostate cancers become resistant to a targeted radiation treatment called 177Lu-PSMA therapy. Researchers will take small tissue samples (biopsies) from 30 patients before and during their treatment to analyze the cancer cells. The goal…