New combo aims to supercharge prostate cancer radiation
NCT ID NCT05113537
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This study tests whether giving abemaciclib before a radioactive drug (177Lu-PSMA-617) can make prostate cancer cells more sensitive to radiation. About 30 men with advanced, treatment-resistant prostate cancer will receive abemaciclib pills for two weeks, then the radioactive therapy. The goal is to see if this sequence is safe and improves tumor shrinkage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Abemaciclib and Lutetium Lu 177-PSMA-617
- What this could lead to
- If successful, this combination could improve treatment effectiveness for advanced prostate cancer that has stopped responding to other therapies.
- What could go wrong
- This is an early phase 1/2 trial with only 30 participants, so results may not apply broadly. Side effects from the drugs or radiation could be significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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- Can targeted radiation tame advanced prostate cancer? a registry aims to find out