STAGE IV PROSTATE CANCER AJCC V8

This study compares two types of radiation therapy for men whose prostate cancer has returned or spread to a few spots after initial surgery. It tests if a shorter, more precise 5-treatment course (SBRT) works as well as a longer 20-treatment course, with potentially fewer side e…

This study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific mutations in genes that help repair DNA damage. It is enrolling 36 adults with various advanced solid tumors (like breast, ovarian, prostate, pancreatic, an…

This large study is testing whether adding surgery to remove the prostate or radiation therapy to standard drug treatments helps men with prostate cancer that has spread to other parts of the body live longer. It will enroll over 1,200 men who have already started standard hormon…

This study compares how well patients tolerate two different drug treatments for advanced prostate cancer. Researchers will follow 75 men taking either abiraterone with prednisone or darolutamide alone for one year. The main goal is to see which treatment causes fewer serious sid…

This study is testing whether giving prostate cancer treatment at home is as safe and effective as receiving it in a clinic. Black men with advanced prostate cancer will receive part of their standard treatment at home with remote monitoring. Researchers want to see if home treat…

This study is testing a two-step treatment for advanced prostate cancer that has spread and stopped responding to standard hormone therapies and chemotherapy. First, patients take a pill (abemaciclib) for two weeks, aiming to make cancer cells more visible. Then, they receive a t…

This study is testing an experimental radioactive drug called lutetium Lu 177 dotatate for men with an aggressive form of prostate cancer that has spread and developed neuroendocrine features. The drug is designed to find and deliver radiation directly to cancer cells. The main g…

This study is testing whether adding a new targeted drug called talazoparib to standard hormone-blocking treatments can better control advanced prostate cancer that has spread. It aims to see if this combination helps stop cancer growth for longer by preventing cancer cells from …

This study is testing if a short course of hormone-blocking pills can make prostate cancer cells 'light up' more brightly on a special imaging scan. The goal is to help doctors see smaller or hidden areas of cancer that have spread, particularly to lymph nodes, in men with high-r…

This study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…

This study is testing whether wearing bright white light therapy glasses can help reduce severe tiredness and low mood in men with advanced prostate cancer who are receiving powerful hormone-based treatments. The main goal is to see if starting the light glasses right away is bet…

This study aims to understand how common low vitamin D levels are in Black men with prostate cancer and to see if taking vitamin D supplements can improve their immune system function. Researchers will enroll 220 participants with a history of prostate cancer, give them vitamin D…

This study is testing whether having a trained peer navigator helps African American men with advanced prostate cancer understand and go through genetic testing better than standard care alone. Genetic testing is important for treatment decisions, but many men face barriers like …