STAGE IV PROSTATE CANCER AJCC V8
Clinical trials for STAGE IV PROSTATE CANCER AJCC V8 explained in plain language.
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New combo aims to boost radiation's punch against hard-to-treat prostate cancer
Disease control Recruiting nowThis study tests whether giving a drug called abemaciclib before a targeted radiation therapy (177Lu-PSMA-617) can help treat metastatic castration-resistant prostate cancer that has stopped responding to other treatments. Abemaciclib may increase the number of targets (PSMA) on …
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Vadim S Koshkin • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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New radiation approach may offer shorter, safer treatment for recurrent prostate cancer
Disease control Recruiting nowThis study tests whether a precise, short-course radiation therapy (SBRT) works as well as a slightly longer radiation approach (hypofractionated radiotherapy) for prostate cancer that has come back or spread to a few spots after surgery. About 118 men with low PSA levels will be…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 14, 2026 12:01 UTC
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Could surgery or radiation boost survival in advanced prostate cancer?
Disease control Recruiting nowThis study is for men with prostate cancer that has spread to other parts of the body. It compares standard drug therapy alone versus standard therapy plus surgery to remove the prostate or radiation to the prostate. The goal is to see if adding local treatment helps patients liv…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated May 12, 2026 13:43 UTC
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New hope for advanced cancers with DNA repair flaws: PARP inhibitor trial opens
Disease control Recruiting nowThis study tests the drug talazoparib in adults with advanced solid tumors (like breast, prostate, ovarian, pancreatic, or stomach cancer) that have certain gene changes affecting DNA repair. The drug blocks a protein called PARP, which cancer cells need to fix their DNA, potenti…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 12, 2026 13:43 UTC
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Radioactive therapy targets Hard-to-Treat prostate cancer
Disease control Recruiting nowThis study tests a radioactive drug called lutetium Lu 177 dotatate in 30 people with prostate cancer that has spread and has neuroendocrine features. The drug targets and kills cancer cells that have a specific protein on their surface. The goal is to see if it can shrink tumors…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 11, 2026 20:41 UTC
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New drug combo shows promise in halting prostate cancer growth
Disease control Recruiting nowThis study tests whether adding a targeted drug called talazoparib to standard hormone therapy can better control prostate cancer that has spread but still responds to hormones. About 70 men with metastatic castration-sensitive prostate cancer will receive the combination. The go…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 01, 2026 15:58 UTC
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Hormone boost before scan may reveal hidden prostate cancer
Diagnosis Recruiting nowThis study tests whether taking a short course of hormone therapy (relugolix) before a PSMA PET/CT scan can make the scan better at finding prostate cancer that has spread. About 30 men with high-risk prostate cancer will get the hormone drug for 5, 10, or 15 days before their sc…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated May 13, 2026 16:03 UTC
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Could cancer care at home beat clinic visits for black men?
Symptom relief Recruiting nowThis study looks at whether giving cancer therapy at home is safer and more satisfying for Black men with advanced prostate cancer compared to receiving it in a clinic. About 38 participants will try both settings and rate their experience. The goal is to reduce stress and improv…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated May 17, 2026 01:00 UTC
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Which prostate cancer drug has fewer side effects? new study aims to find out
Symptom relief Recruiting nowThis study compares the side effects of two standard treatments for advanced prostate cancer: abiraterone plus prednisone versus darolutamide alone. About 75 men with prostate cancer that has spread will be enrolled. The goal is to see which treatment causes fewer severe side eff…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of California, Davis • Aim: Symptom relief
Last updated May 17, 2026 00:50 UTC
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Shining a light on cancer fatigue: new study tests bright light therapy for men on hormone treatment
Symptom relief Recruiting nowThis study tests whether using bright white light therapy glasses can reduce fatigue and improve mood in men with advanced prostate cancer who are receiving hormone therapy (ADT) combined with other treatments. About 210 men will either start light therapy right away or wait a fe…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Symptom relief
Last updated May 15, 2026 11:53 UTC
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Freeze and zap: new combo therapy aims to crush bone cancer pain
Symptom relief Recruiting nowThis study tests whether freezing bone tumors (cryoablation) before giving radiation therapy works better than radiation alone for reducing pain. About 40 adults with cancer that has spread to the bones will be enrolled. The goal is to see if the combination provides more complet…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 13, 2026 15:58 UTC
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Vitamin d study seeks to unlock immune secrets in black prostate cancer patients
Knowledge-focused Recruiting nowThis study looks at how common low vitamin D levels are in African American men with prostate cancer, and whether correcting those levels can improve immune function. Researchers will measure vitamin D and immune cells in blood samples before and after supplementation. The goal i…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: EARLY_PHASE1 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 17, 2026 00:59 UTC
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Peer navigators may close genetic testing gap for black men with prostate cancer
Knowledge-focused Recruiting nowThis study looks at whether having a trained peer navigator—someone who guides patients through the process—helps African American men with prostate cancer that has spread understand and complete genetic testing. Genetic testing is important for treatment decisions, but many Afri…
Matched conditions: STAGE IV PROSTATE CANCER AJCC V8
Phase: NA • Sponsor: Thomas Jefferson University • Aim: Knowledge-focused
Last updated May 14, 2026 12:02 UTC