CASTRATION-RESISTANT PROSTATE CARCINOMA
Clinical trials for CASTRATION-RESISTANT PROSTATE CARCINOMA explained in plain language.
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Fighting fire with fire: High-Testosterone therapy aims to shock resistant prostate cancer
Disease control Recruiting nowThis study is testing if giving very high doses of testosterone, along with chemotherapy or a targeted radiation drug, can help control advanced prostate cancer that has spread and stopped responding to standard hormone-lowering treatments. The idea is to shock cancer cells that …
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Could a break from cancer treatment be just as effective?
Disease control Recruiting nowThis study is testing if taking a planned break from a targeted radiation treatment is as effective as continuing it without a pause for men with advanced prostate cancer that has spread. The goal is to see if a shorter treatment course can control the cancer just as well while p…
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Scientists test re-engineered immune cells to fight spreading prostate cancer
Disease control Recruiting nowThis early-stage study is testing the safety and best dose of a personalized immune therapy for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. Doctors take a patient's own immune cells, modify them in a lab to better targe…
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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New hope for Tough-to-Treat prostate cancer: Two-Drug combo enters major trial
Disease control Recruiting nowThis study is for men with advanced prostate cancer that has spread and no longer responds to standard hormone-lowering treatments. It will test if adding a chemotherapy drug called carboplatin to the standard chemotherapy drug cabazitaxel works better than cabazitaxel alone. The…
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE3 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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New hope for Tough-to-Treat prostate cancer
Disease control Recruiting nowThis study is testing if adding a drug called vorinostat makes a newer radioactive cancer treatment work better for men with advanced prostate cancer. The cancer has spread and stopped responding to standard hormone treatments. Researchers want to see if vorinostat can 'turn on' …
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Second shot at life: repeating a Cancer-Killing radiation treatment
Disease control Recruiting nowThis study is testing whether giving a second course of a targeted radiation drug can help men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The treatment, called 177Lu-PSMA-617, is given by IV and seeks out and delivers radiati…
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE2 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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New trial tests if switching PARP inhibitors can help control advanced cancers
Disease control Recruiting nowThis study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific mutations in genes that help repair DNA damage. It is enrolling 36 adults with various advanced solid tumors (like breast, ovarian, prostate, pancreatic, an…
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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New hope for tough prostate cancer: Two-Drug attack begins human testing
Disease control Recruiting nowThis early-stage study is testing whether adding the drug ruxolitinib to the standard treatment enzalutamide is safe and effective for men with advanced prostate cancer that has stopped responding to hormone-blocking therapy. The goal is to find the best dose and see if this comb…
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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DNA clues could predict which prostate cancer patients benefit from Bone-Targeting drug
Disease control Recruiting nowThis study aims to understand why some men with advanced prostate cancer that has spread to bones respond better to the drug radium-223 than others. Researchers will test blood samples from 48 patients to look for specific DNA repair defects that might make the cancer more sensit…
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Sponsor: University of Washington • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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New immune cell therapy targets advanced prostate cancer that has stopped responding to standard treatments
Disease control Recruiting nowThis trial tests whether a new type of cell therapy (STEAP1 CART) combined with the hormone drug enzalutamide can help control advanced prostate cancer that has spread and stopped responding to standard treatments. The study will enroll 48 men whose cancer has progressed despite …
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Mar 23, 2026 15:14 UTC
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Paradoxical approach: giving testosterone to fight prostate cancer
Disease control Recruiting nowThis early-stage study is testing a counterintuitive approach for men with advanced prostate cancer that has stopped responding to standard hormone-blocking treatments. Researchers are giving patients cycles of testosterone injections to see if rapidly switching between very low …
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE1 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Mar 16, 2026 15:27 UTC
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Scientists test Two-Drug punch for tough prostate cancer
Disease control Recruiting nowThis study is testing a two-step treatment for advanced prostate cancer that has spread and stopped responding to standard hormone therapies and chemotherapy. First, patients take a pill (abemaciclib) for two weeks, aiming to make cancer cells more visible. Then, they receive a t…
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Vadim S Koshkin • Aim: Disease control
Last updated Mar 16, 2026 15:26 UTC
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Genetic testing trial aims to match men with best prostate cancer drug
Disease control Recruiting nowThis study is testing whether using genetic testing to guide treatment choices works better for men with advanced prostate cancer that has stopped responding to standard hormone therapy. About 474 participants will have their tumor tissue analyzed, and then be assigned to one of …
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Mar 02, 2026 15:29 UTC
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Freezing cancer to stop the pain: new combo therapy trial
Symptom relief Recruiting nowThis study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Mar 31, 2026 12:11 UTC
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Scientists probe prostate Cancer's defenses against radiation
Knowledge-focused Recruiting nowThis study aims to learn why some advanced prostate cancers become resistant to a targeted radiation treatment called 177Lu-PSMA therapy. Researchers will take small tissue samples (biopsies) from 30 patients before and during their treatment to analyze the cancer cells. The goal…
Matched conditions: CASTRATION-RESISTANT PROSTATE CARCINOMA
Phase: PHASE1 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC